Effect of metformin on semen quality

Effect of metformin on semen quality

ABSTRACT Various studies have linked metformin, a universally antidiabetic drug, with semen quality; however, such a direct link has not been established. This review systematically addresses and summarizes the effect of metformin on semen quality, particularly sperm function. We searched the MEDLINE electronic database for English articles and abstracts containing the key words 'metformin' and 'sperm', and relevant articles were reviewed. In summary, metformin appears to have improved and provided positive impact on sperm quality. This effect may be due to the ability of metformin to reduce oxidative stress and lipid peroxidation, enhance 5'-AMP activated protein kinase activity, and restore the normal levels of pituitary-gonadal hormones. However, further clinical research is still necessary to confirm such effect.

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Main Author: Banihani,Saleem Ali
Format: Digital revista
Language:English
Published: Universidade de São Paulo, Faculdade de Ciências Farmacêuticas 2016
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400591
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spelling oai:scielo:S1984-825020160004005912017-02-21Effect of metformin on semen qualityBanihani,Saleem Ali Metformin/effects Metformin/review Metformin/semen quality Sperm/study Testosterone Oxidative stress 5'-AMP activated protein kinase. ABSTRACT Various studies have linked metformin, a universally antidiabetic drug, with semen quality; however, such a direct link has not been established. This review systematically addresses and summarizes the effect of metformin on semen quality, particularly sperm function. We searched the MEDLINE electronic database for English articles and abstracts containing the key words 'metformin' and 'sperm', and relevant articles were reviewed. In summary, metformin appears to have improved and provided positive impact on sperm quality. This effect may be due to the ability of metformin to reduce oxidative stress and lipid peroxidation, enhance 5'-AMP activated protein kinase activity, and restore the normal levels of pituitary-gonadal hormones. However, further clinical research is still necessary to confirm such effect.info:eu-repo/semantics/openAccessUniversidade de São Paulo, Faculdade de Ciências FarmacêuticasBrazilian Journal of Pharmaceutical Sciences v.52 n.4 20162016-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400591en10.1590/s1984-82502016000400002
institution SCIELO
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country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
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region America del Sur
libraryname SciELO
language English
format Digital
author Banihani,Saleem Ali
spellingShingle Banihani,Saleem Ali
Effect of metformin on semen quality
author_facet Banihani,Saleem Ali
author_sort Banihani,Saleem Ali
title Effect of metformin on semen quality
title_short Effect of metformin on semen quality
title_full Effect of metformin on semen quality
title_fullStr Effect of metformin on semen quality
title_full_unstemmed Effect of metformin on semen quality
title_sort effect of metformin on semen quality
description ABSTRACT Various studies have linked metformin, a universally antidiabetic drug, with semen quality; however, such a direct link has not been established. This review systematically addresses and summarizes the effect of metformin on semen quality, particularly sperm function. We searched the MEDLINE electronic database for English articles and abstracts containing the key words 'metformin' and 'sperm', and relevant articles were reviewed. In summary, metformin appears to have improved and provided positive impact on sperm quality. This effect may be due to the ability of metformin to reduce oxidative stress and lipid peroxidation, enhance 5'-AMP activated protein kinase activity, and restore the normal levels of pituitary-gonadal hormones. However, further clinical research is still necessary to confirm such effect.
publisher Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
publishDate 2016
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400591
work_keys_str_mv AT banihanisaleemali effectofmetforminonsemenquality
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