Antitumor activity of leaves of Himatanthus drasticus (Mart.) Plumel-Apocynaceae (janaguba) in the treatment of Sarcoma 180 tumor

Himatanthus drasticus, also known as janaguba, is used popularly in Brazil's Northeastern region in the treatment of cancer. However, no scientific reports are available. The present study is the first investigation on the antitumor activity of crude methanolic extract from Himatanthus drasticus leaves against Sarcoma 180 tumor and on its side effects including acute oral toxicity. The OECD 423 methodology was used to study acute oral toxicity, and the STOCK methodology to assess antitumor activity. The crude extract showed low toxicity at the tested doses (50, 300 and 2000 mg/kg) administered orally. The histopathological analyses demonstrated alterations in liver lung, spleen and kidney. It also showed activity against Sarcoma 180 tumor in male Swiss albino mice, evidencing tumor growth inhibition of 67.7% and 68% at 300 mg/kg and 400 mg/kg doses, respectively.

Bibliographic Details

Main Authors:	Sousa,Eliane Leite de, Grangeiro,Ana Ruth Sampaio, Bastos,Isla Vanessa Gomes Alves, Rodrigues,Guilherme Carvalho Ribeiro, Silva,Maria Joselice e, Anjos,Falba Bernadete Ramos dos, Souza,Ivone Antonia de, Sousa,Cicero Ernandes Leite de
Format:	Digital revista
Language:	English
Published:	Universidade de São Paulo, Faculdade de Ciências Farmacêuticas 2010
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200005
Tags:	Add Tag No Tags, Be the first to tag this record!