Action of anti-TNF-α drugs on the progression of Alzheimer's disease: A case report
The aim of this study was to describe a clinical case of a patient with Alzheimer's disease (AD) in use of an anti-TNF-α agent for rheumatoid arthritis (RA). The patient reported is an 81-year-old Caucasian man and retired teacher, diagnosed with RA in 2008 and AD in 2011. Treatment with donepezil was started in 2011 and the use of etanercept introduced in 2012. He was previously treated with adalimumab in 2010 for 18 months. In 2013, the subject was engaged in a clinical trial to assess a complementary non-pharmacological approach for AD, presenting significant cognitive improvement during the follow-up period. We propose the hypothesis of a synergistic effect of anti-TNF-α medication used for the treatment of RA as the cause of the improvement in cognitive response observed. These findings could suggest a possible use of this drug class in the therapeutic management of AD.
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Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
2015
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oai:scielo:S1980-576420150002001962015-07-02Action of anti-TNF-α drugs on the progression of Alzheimer's disease: A case reportCamargo,Carlos Henrique FerreiraJustus,Filipe FernandesRetzlaff,GiulianoBlood,Marcelo Rezende YoungSchafranski,Marcelo Derbli TNF-α Alzheimer's disease rheumatoid arthritis The aim of this study was to describe a clinical case of a patient with Alzheimer's disease (AD) in use of an anti-TNF-α agent for rheumatoid arthritis (RA). The patient reported is an 81-year-old Caucasian man and retired teacher, diagnosed with RA in 2008 and AD in 2011. Treatment with donepezil was started in 2011 and the use of etanercept introduced in 2012. He was previously treated with adalimumab in 2010 for 18 months. In 2013, the subject was engaged in a clinical trial to assess a complementary non-pharmacological approach for AD, presenting significant cognitive improvement during the follow-up period. We propose the hypothesis of a synergistic effect of anti-TNF-α medication used for the treatment of RA as the cause of the improvement in cognitive response observed. These findings could suggest a possible use of this drug class in the therapeutic management of AD.info:eu-repo/semantics/openAccessAcademia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e EnvelhecimentoDementia & Neuropsychologia v.9 n.2 20152015-06-01info:eu-repo/semantics/reporttext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642015000200196en10.1590/1980-57642015DN92000015 |
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Camargo,Carlos Henrique Ferreira Justus,Filipe Fernandes Retzlaff,Giuliano Blood,Marcelo Rezende Young Schafranski,Marcelo Derbli |
spellingShingle |
Camargo,Carlos Henrique Ferreira Justus,Filipe Fernandes Retzlaff,Giuliano Blood,Marcelo Rezende Young Schafranski,Marcelo Derbli Action of anti-TNF-α drugs on the progression of Alzheimer's disease: A case report |
author_facet |
Camargo,Carlos Henrique Ferreira Justus,Filipe Fernandes Retzlaff,Giuliano Blood,Marcelo Rezende Young Schafranski,Marcelo Derbli |
author_sort |
Camargo,Carlos Henrique Ferreira |
title |
Action of anti-TNF-α drugs on the progression of Alzheimer's disease: A case report |
title_short |
Action of anti-TNF-α drugs on the progression of Alzheimer's disease: A case report |
title_full |
Action of anti-TNF-α drugs on the progression of Alzheimer's disease: A case report |
title_fullStr |
Action of anti-TNF-α drugs on the progression of Alzheimer's disease: A case report |
title_full_unstemmed |
Action of anti-TNF-α drugs on the progression of Alzheimer's disease: A case report |
title_sort |
action of anti-tnf-α drugs on the progression of alzheimer's disease: a case report |
description |
The aim of this study was to describe a clinical case of a patient with Alzheimer's disease (AD) in use of an anti-TNF-α agent for rheumatoid arthritis (RA). The patient reported is an 81-year-old Caucasian man and retired teacher, diagnosed with RA in 2008 and AD in 2011. Treatment with donepezil was started in 2011 and the use of etanercept introduced in 2012. He was previously treated with adalimumab in 2010 for 18 months. In 2013, the subject was engaged in a clinical trial to assess a complementary non-pharmacological approach for AD, presenting significant cognitive improvement during the follow-up period. We propose the hypothesis of a synergistic effect of anti-TNF-α medication used for the treatment of RA as the cause of the improvement in cognitive response observed. These findings could suggest a possible use of this drug class in the therapeutic management of AD. |
publisher |
Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento |
publishDate |
2015 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642015000200196 |
work_keys_str_mv |
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1756434472634417152 |