Sinonasal disorders in hematopoietic stem cell transplantation
INTRODUCTION: hematopoietic stem cell transplantation (HSCT) is associated with more respiratory infections due to immunosuppression. OBJECTIVE: this study aimed to verify the frequency of rhinosinusitis after HSCT, and the association between rhinosinusitis and chronic graft vs. host disease (GVHD) and type of transplantation, clinical treatment, surgical treatment, and survival. METHODS: this was a retrospective study in a tertiary university hospital. A total of 95 patients with hematological diseases undergoing HSCT between 1996 and 2011 were selected. RESULTS: chronic myeloid leukemia was the most prevalent disease. The type of transplant most often performed was the allogenic type (85.26%). The frequency of rhinosinusitis was 36%, with no difference between the autologous and the allogenic types. Chronic GVHD occurred in 30% of patients. Patients with GVHD had a higher frequency and recurrence of rhinosinusitis, in addition to more frequent need for endoscopic sinusectomy and decreased overall survival. CONCLUSION: there was a higher frequency of rhinosinusitis in HSCT and GVHD. The type of transplant does not appear to predispose to the occurrence of rhinosinusitis. GVHD seems to be an aggravating factor and requires a more stringent treatment.
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Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.
2014
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oai:scielo:S1808-869420140004002852015-08-25Sinonasal disorders in hematopoietic stem cell transplantation Bento,Lucas RicciOrtiz,EricaNicola,Ester Maria DanieliVigorito,Afonso C.Sakano,Eulalia Sinusitis Hematopoietic stem cell transplantation Therapeutic conducts Graft vs. host disease INTRODUCTION: hematopoietic stem cell transplantation (HSCT) is associated with more respiratory infections due to immunosuppression. OBJECTIVE: this study aimed to verify the frequency of rhinosinusitis after HSCT, and the association between rhinosinusitis and chronic graft vs. host disease (GVHD) and type of transplantation, clinical treatment, surgical treatment, and survival. METHODS: this was a retrospective study in a tertiary university hospital. A total of 95 patients with hematological diseases undergoing HSCT between 1996 and 2011 were selected. RESULTS: chronic myeloid leukemia was the most prevalent disease. The type of transplant most often performed was the allogenic type (85.26%). The frequency of rhinosinusitis was 36%, with no difference between the autologous and the allogenic types. Chronic GVHD occurred in 30% of patients. Patients with GVHD had a higher frequency and recurrence of rhinosinusitis, in addition to more frequent need for endoscopic sinusectomy and decreased overall survival. CONCLUSION: there was a higher frequency of rhinosinusitis in HSCT and GVHD. The type of transplant does not appear to predispose to the occurrence of rhinosinusitis. GVHD seems to be an aggravating factor and requires a more stringent treatment. info:eu-repo/semantics/openAccessAssociação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.Brazilian Journal of Otorhinolaryngology v.80 n.4 20142014-08-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942014000400285en10.1016/j.bjorl.2014.05.009 |
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Bento,Lucas Ricci Ortiz,Erica Nicola,Ester Maria Danieli Vigorito,Afonso C. Sakano,Eulalia |
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Bento,Lucas Ricci Ortiz,Erica Nicola,Ester Maria Danieli Vigorito,Afonso C. Sakano,Eulalia Sinonasal disorders in hematopoietic stem cell transplantation |
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Bento,Lucas Ricci Ortiz,Erica Nicola,Ester Maria Danieli Vigorito,Afonso C. Sakano,Eulalia |
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Bento,Lucas Ricci |
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Sinonasal disorders in hematopoietic stem cell transplantation |
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Sinonasal disorders in hematopoietic stem cell transplantation |
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Sinonasal disorders in hematopoietic stem cell transplantation |
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Sinonasal disorders in hematopoietic stem cell transplantation |
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Sinonasal disorders in hematopoietic stem cell transplantation |
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sinonasal disorders in hematopoietic stem cell transplantation |
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INTRODUCTION: hematopoietic stem cell transplantation (HSCT) is associated with more respiratory infections due to immunosuppression. OBJECTIVE: this study aimed to verify the frequency of rhinosinusitis after HSCT, and the association between rhinosinusitis and chronic graft vs. host disease (GVHD) and type of transplantation, clinical treatment, surgical treatment, and survival. METHODS: this was a retrospective study in a tertiary university hospital. A total of 95 patients with hematological diseases undergoing HSCT between 1996 and 2011 were selected. RESULTS: chronic myeloid leukemia was the most prevalent disease. The type of transplant most often performed was the allogenic type (85.26%). The frequency of rhinosinusitis was 36%, with no difference between the autologous and the allogenic types. Chronic GVHD occurred in 30% of patients. Patients with GVHD had a higher frequency and recurrence of rhinosinusitis, in addition to more frequent need for endoscopic sinusectomy and decreased overall survival. CONCLUSION: there was a higher frequency of rhinosinusitis in HSCT and GVHD. The type of transplant does not appear to predispose to the occurrence of rhinosinusitis. GVHD seems to be an aggravating factor and requires a more stringent treatment. |
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Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. |
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2014 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-86942014000400285 |
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