Maternal vitamin D level in the first trimester and pregnancy outcomes: a prospective study

Abstract Overview and aims: Recent studies suggested that low vitamin D levels during pregnancy can increase the risk of pre-eclampsia, gestational diabetes mellitus, cesarean section, preterm birth, and low birthweight. This study aims to investigate the association between first trimester vitamin D status and pregnancy outcomes. Study design, Population and Methods: A prospective observational study was performed including women with vitamin D measurement in the first trimester of pregnancy. Results: One hundred and eighty five pregnant women were recruited. There were 141 (76,2%) women who revealed low levels of vitamin D. With regards to pregnancy outcomes, there was no significant association between vitamin D status and preeclampsia, cesarean section, preterm birth, and low birthweight. Low vitamin D level was associated with a higher risk of gestational diabetes (adjusted odds ratio, 0.876, CI 0.789-0.972; p=0.013). Conclusions: A high prevalence of low vitamin D levels among pregnant women in the first trimester was seen in the Portuguese population. Low vitamin D level in the first trimester of pregnancy was a predictor of gestational diabetes mellitus.

Bibliographic Details

Main Authors:	Gomes,Marina Sousa, Cambão,Maria Luís, Trocado,Vera, Pereira,Joana Araújo, Silva,Sara Passos, Mesquita,Jorge, Pinheiro,Paula
Format:	Digital revista
Language:	English
Published:	Euromédice, Edições Médicas Lda. 2021
Online Access:	http://scielo.pt/scielo.php?script=sci_arttext&pid=S1646-58302021000100017
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