Prevalence of the precore G1896A mutation in Chinese patients with e antigen negative hepatitis B virus infection and its relationship to pre-S1 antigen

This study investigated the prevalence of the precore G1896A mutation in Chinese patients with hepatitis B e antigen (HBeAg) negative HBV infection and its relation to serum HBV pre-S1 antigen. The overall prevalence of the precore G1896A mutation was 72.6% in HBeAg-negative Chinese patients with detectable serum HBV DNA. The prevalence of the precore G1896A is significantly higher in Chinese HBeAg-negative patients with chronic hepatitis B than that in inactive HBV carriers with detectable serum HBV DNA. Serum pre-S1 and the precore G1896A mutation were simultaneously detected in most of Chinese HBeAg-negative patients.

Bibliographic Details

Main Authors:	Zhang,Jing, Xu,Wei-Jia, Wang,Qing, Zhang,Yong, Shi,Ming
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Microbiologia 2009
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822009000400031
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