Evaluation of hela cell lineage response to β radiation from Holmium-166 embedded in ceramic seeds
This work studied the effects of β radiation of Ho-166 embedded in ceramic seeds on HeLa cells. Methodology consisted in the production of ceramic seeds with holmium-165 by sol-gel route. Chemical and physical characterizations of the seeds were performed. Subsequently, nuclear characterization was performed by gamma spectrometry. Experimental and theoretical activities were defined and initial dose rate were evaluated by MIRD (Medical Internal Radiation Dose Committee) methodology. The seeds were placed in confluent culture flasks and remained for six radionuclide half-lives. Biological results were represented by a clean 6 mm diameter area around the seed where the tumour cells were killed. The initial dose rate was 15.5 Gy. h-1. The maximum absorbed dose was 591.3 Gy. The features of the Ho-166 seeds suggested that such ceramic seeds were suitable for high dose rate brachytherapy.
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Instituto de Tecnologia do Paraná - Tecpar
2011
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oai:scielo:S1516-891320110005000132011-11-01Evaluation of hela cell lineage response to β radiation from Holmium-166 embedded in ceramic seedsValente,Eduardo SarmentoCuperschmid,Ethel MizrahyCampos,Tarcisio Passos Ribeiro de Brachytherapy ceramic seeds holmium cancer control HeLa cells This work studied the effects of β radiation of Ho-166 embedded in ceramic seeds on HeLa cells. Methodology consisted in the production of ceramic seeds with holmium-165 by sol-gel route. Chemical and physical characterizations of the seeds were performed. Subsequently, nuclear characterization was performed by gamma spectrometry. Experimental and theoretical activities were defined and initial dose rate were evaluated by MIRD (Medical Internal Radiation Dose Committee) methodology. The seeds were placed in confluent culture flasks and remained for six radionuclide half-lives. Biological results were represented by a clean 6 mm diameter area around the seed where the tumour cells were killed. The initial dose rate was 15.5 Gy. h-1. The maximum absorbed dose was 591.3 Gy. The features of the Ho-166 seeds suggested that such ceramic seeds were suitable for high dose rate brachytherapy.info:eu-repo/semantics/openAccessInstituto de Tecnologia do Paraná - TecparBrazilian Archives of Biology and Technology v.54 n.5 20112011-10-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000500013en10.1590/S1516-89132011000500013 |
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Valente,Eduardo Sarmento Cuperschmid,Ethel Mizrahy Campos,Tarcisio Passos Ribeiro de |
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Valente,Eduardo Sarmento Cuperschmid,Ethel Mizrahy Campos,Tarcisio Passos Ribeiro de Evaluation of hela cell lineage response to β radiation from Holmium-166 embedded in ceramic seeds |
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Valente,Eduardo Sarmento Cuperschmid,Ethel Mizrahy Campos,Tarcisio Passos Ribeiro de |
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Valente,Eduardo Sarmento |
title |
Evaluation of hela cell lineage response to β radiation from Holmium-166 embedded in ceramic seeds |
title_short |
Evaluation of hela cell lineage response to β radiation from Holmium-166 embedded in ceramic seeds |
title_full |
Evaluation of hela cell lineage response to β radiation from Holmium-166 embedded in ceramic seeds |
title_fullStr |
Evaluation of hela cell lineage response to β radiation from Holmium-166 embedded in ceramic seeds |
title_full_unstemmed |
Evaluation of hela cell lineage response to β radiation from Holmium-166 embedded in ceramic seeds |
title_sort |
evaluation of hela cell lineage response to β radiation from holmium-166 embedded in ceramic seeds |
description |
This work studied the effects of β radiation of Ho-166 embedded in ceramic seeds on HeLa cells. Methodology consisted in the production of ceramic seeds with holmium-165 by sol-gel route. Chemical and physical characterizations of the seeds were performed. Subsequently, nuclear characterization was performed by gamma spectrometry. Experimental and theoretical activities were defined and initial dose rate were evaluated by MIRD (Medical Internal Radiation Dose Committee) methodology. The seeds were placed in confluent culture flasks and remained for six radionuclide half-lives. Biological results were represented by a clean 6 mm diameter area around the seed where the tumour cells were killed. The initial dose rate was 15.5 Gy. h-1. The maximum absorbed dose was 591.3 Gy. The features of the Ho-166 seeds suggested that such ceramic seeds were suitable for high dose rate brachytherapy. |
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Instituto de Tecnologia do Paraná - Tecpar |
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2011 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000500013 |
work_keys_str_mv |
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