Prevalence of cervical intraepithelial neoplasia grades II/III and cervical cancer in patients with cytological diagnosis of atypical squamous cells when high-grade intraepithelial lesions (ASC-H) cannot be ruled out
CONTEXT AND OBJECTIVE: The latest update of the Bethesda System divided the category of atypical squamous cells of undetermined significance (ASCUS) into ASC-US (undetermined significance) and ASC-H (high-grade intraepithelial lesion cannot be ruled out). The aims here were to measure the prevalence of pre-invasive lesions (cervical intraepithelial neoplasia, CIN II/III) and cervical cancer among patients referred to Instituto Fernandes Figueira (IFF) with ASC-H cytology, and compare them with ASC-US cases. DESIGN AND SETTING: Cross-sectional study with retrospective data collection, at the IFF Cervical Pathology outpatient clinic. METHODS: ASCUS cases referred to IFF from November 1997 to September 2007 were reviewed according to the 2001 Bethesda System to reach cytological consensus. The resulting ASC-H and ASC-US cases, along with new cases, were analyzed relative to the outcome of interest. The histological diagnosis (or cytocolposcopic follow-up in cases without such diagnosis) was taken as the gold standard. RESULTS: The prevalence of CIN II/III in cases with ASC-H cytology was 19.29% (95% confidence interval, CI, 9.05-29.55%) and the risk of these lesions was greater among patients with ASC-H than with ASC-US cytology (prevalence ratio, PR, 10.42; 95% CI, 2.39-45.47; P = 0.0000764). Pre-invasive lesions were more frequently found in patients under 50 years of age with ASC-H cytology (PR, 2.67; 95% CI, 0.38-18.83); P = 0.2786998). There were no uterine cervical cancer cases. CONCLUSION: The prevalence of CIN II/III in patients with ASC-H cytology was significantly higher than with ASC-US, and division into ASC diagnostic subcategories had good capacity for discriminating the presence of pre-invasive lesions.
Main Authors: | , , , , , , , |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Associação Paulista de Medicina - APM
2009
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802009000500007 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
oai:scielo:S1516-31802009000500007 |
---|---|
record_format |
ojs |
spelling |
oai:scielo:S1516-318020090005000072010-02-03Prevalence of cervical intraepithelial neoplasia grades II/III and cervical cancer in patients with cytological diagnosis of atypical squamous cells when high-grade intraepithelial lesions (ASC-H) cannot be ruled outCytryn,AndréaRussomano,Fábio BastosCamargo,Maria José deZardo,Lucília Maria GamaHorta,Nilza Maria Sobral RebeloFonseca,Rachel de Carvalho Silveira de PaulaTristão,Maria AparecidaMonteiro,Aparecida Cristina Sampaio Cytology Colposcopy Cervical intraepithelial neoplasia Uterine cervical neoplasm Cervix uteri CONTEXT AND OBJECTIVE: The latest update of the Bethesda System divided the category of atypical squamous cells of undetermined significance (ASCUS) into ASC-US (undetermined significance) and ASC-H (high-grade intraepithelial lesion cannot be ruled out). The aims here were to measure the prevalence of pre-invasive lesions (cervical intraepithelial neoplasia, CIN II/III) and cervical cancer among patients referred to Instituto Fernandes Figueira (IFF) with ASC-H cytology, and compare them with ASC-US cases. DESIGN AND SETTING: Cross-sectional study with retrospective data collection, at the IFF Cervical Pathology outpatient clinic. METHODS: ASCUS cases referred to IFF from November 1997 to September 2007 were reviewed according to the 2001 Bethesda System to reach cytological consensus. The resulting ASC-H and ASC-US cases, along with new cases, were analyzed relative to the outcome of interest. The histological diagnosis (or cytocolposcopic follow-up in cases without such diagnosis) was taken as the gold standard. RESULTS: The prevalence of CIN II/III in cases with ASC-H cytology was 19.29% (95% confidence interval, CI, 9.05-29.55%) and the risk of these lesions was greater among patients with ASC-H than with ASC-US cytology (prevalence ratio, PR, 10.42; 95% CI, 2.39-45.47; P = 0.0000764). Pre-invasive lesions were more frequently found in patients under 50 years of age with ASC-H cytology (PR, 2.67; 95% CI, 0.38-18.83); P = 0.2786998). There were no uterine cervical cancer cases. CONCLUSION: The prevalence of CIN II/III in patients with ASC-H cytology was significantly higher than with ASC-US, and division into ASC diagnostic subcategories had good capacity for discriminating the presence of pre-invasive lesions.info:eu-repo/semantics/openAccessAssociação Paulista de Medicina - APMSao Paulo Medical Journal v.127 n.5 20092009-09-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802009000500007en10.1590/S1516-31802009000500007 |
institution |
SCIELO |
collection |
OJS |
country |
Brasil |
countrycode |
BR |
component |
Revista |
access |
En linea |
databasecode |
rev-scielo-br |
tag |
revista |
region |
America del Sur |
libraryname |
SciELO |
language |
English |
format |
Digital |
author |
Cytryn,Andréa Russomano,Fábio Bastos Camargo,Maria José de Zardo,Lucília Maria Gama Horta,Nilza Maria Sobral Rebelo Fonseca,Rachel de Carvalho Silveira de Paula Tristão,Maria Aparecida Monteiro,Aparecida Cristina Sampaio |
spellingShingle |
Cytryn,Andréa Russomano,Fábio Bastos Camargo,Maria José de Zardo,Lucília Maria Gama Horta,Nilza Maria Sobral Rebelo Fonseca,Rachel de Carvalho Silveira de Paula Tristão,Maria Aparecida Monteiro,Aparecida Cristina Sampaio Prevalence of cervical intraepithelial neoplasia grades II/III and cervical cancer in patients with cytological diagnosis of atypical squamous cells when high-grade intraepithelial lesions (ASC-H) cannot be ruled out |
author_facet |
Cytryn,Andréa Russomano,Fábio Bastos Camargo,Maria José de Zardo,Lucília Maria Gama Horta,Nilza Maria Sobral Rebelo Fonseca,Rachel de Carvalho Silveira de Paula Tristão,Maria Aparecida Monteiro,Aparecida Cristina Sampaio |
author_sort |
Cytryn,Andréa |
title |
Prevalence of cervical intraepithelial neoplasia grades II/III and cervical cancer in patients with cytological diagnosis of atypical squamous cells when high-grade intraepithelial lesions (ASC-H) cannot be ruled out |
title_short |
Prevalence of cervical intraepithelial neoplasia grades II/III and cervical cancer in patients with cytological diagnosis of atypical squamous cells when high-grade intraepithelial lesions (ASC-H) cannot be ruled out |
title_full |
Prevalence of cervical intraepithelial neoplasia grades II/III and cervical cancer in patients with cytological diagnosis of atypical squamous cells when high-grade intraepithelial lesions (ASC-H) cannot be ruled out |
title_fullStr |
Prevalence of cervical intraepithelial neoplasia grades II/III and cervical cancer in patients with cytological diagnosis of atypical squamous cells when high-grade intraepithelial lesions (ASC-H) cannot be ruled out |
title_full_unstemmed |
Prevalence of cervical intraepithelial neoplasia grades II/III and cervical cancer in patients with cytological diagnosis of atypical squamous cells when high-grade intraepithelial lesions (ASC-H) cannot be ruled out |
title_sort |
prevalence of cervical intraepithelial neoplasia grades ii/iii and cervical cancer in patients with cytological diagnosis of atypical squamous cells when high-grade intraepithelial lesions (asc-h) cannot be ruled out |
description |
CONTEXT AND OBJECTIVE: The latest update of the Bethesda System divided the category of atypical squamous cells of undetermined significance (ASCUS) into ASC-US (undetermined significance) and ASC-H (high-grade intraepithelial lesion cannot be ruled out). The aims here were to measure the prevalence of pre-invasive lesions (cervical intraepithelial neoplasia, CIN II/III) and cervical cancer among patients referred to Instituto Fernandes Figueira (IFF) with ASC-H cytology, and compare them with ASC-US cases. DESIGN AND SETTING: Cross-sectional study with retrospective data collection, at the IFF Cervical Pathology outpatient clinic. METHODS: ASCUS cases referred to IFF from November 1997 to September 2007 were reviewed according to the 2001 Bethesda System to reach cytological consensus. The resulting ASC-H and ASC-US cases, along with new cases, were analyzed relative to the outcome of interest. The histological diagnosis (or cytocolposcopic follow-up in cases without such diagnosis) was taken as the gold standard. RESULTS: The prevalence of CIN II/III in cases with ASC-H cytology was 19.29% (95% confidence interval, CI, 9.05-29.55%) and the risk of these lesions was greater among patients with ASC-H than with ASC-US cytology (prevalence ratio, PR, 10.42; 95% CI, 2.39-45.47; P = 0.0000764). Pre-invasive lesions were more frequently found in patients under 50 years of age with ASC-H cytology (PR, 2.67; 95% CI, 0.38-18.83); P = 0.2786998). There were no uterine cervical cancer cases. CONCLUSION: The prevalence of CIN II/III in patients with ASC-H cytology was significantly higher than with ASC-US, and division into ASC diagnostic subcategories had good capacity for discriminating the presence of pre-invasive lesions. |
publisher |
Associação Paulista de Medicina - APM |
publishDate |
2009 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802009000500007 |
work_keys_str_mv |
AT cytrynandrea prevalenceofcervicalintraepithelialneoplasiagradesiiiiiandcervicalcancerinpatientswithcytologicaldiagnosisofatypicalsquamouscellswhenhighgradeintraepitheliallesionsaschcannotberuledout AT russomanofabiobastos prevalenceofcervicalintraepithelialneoplasiagradesiiiiiandcervicalcancerinpatientswithcytologicaldiagnosisofatypicalsquamouscellswhenhighgradeintraepitheliallesionsaschcannotberuledout AT camargomariajosede prevalenceofcervicalintraepithelialneoplasiagradesiiiiiandcervicalcancerinpatientswithcytologicaldiagnosisofatypicalsquamouscellswhenhighgradeintraepitheliallesionsaschcannotberuledout AT zardoluciliamariagama prevalenceofcervicalintraepithelialneoplasiagradesiiiiiandcervicalcancerinpatientswithcytologicaldiagnosisofatypicalsquamouscellswhenhighgradeintraepitheliallesionsaschcannotberuledout AT hortanilzamariasobralrebelo prevalenceofcervicalintraepithelialneoplasiagradesiiiiiandcervicalcancerinpatientswithcytologicaldiagnosisofatypicalsquamouscellswhenhighgradeintraepitheliallesionsaschcannotberuledout AT fonsecaracheldecarvalhosilveiradepaula prevalenceofcervicalintraepithelialneoplasiagradesiiiiiandcervicalcancerinpatientswithcytologicaldiagnosisofatypicalsquamouscellswhenhighgradeintraepitheliallesionsaschcannotberuledout AT tristaomariaaparecida prevalenceofcervicalintraepithelialneoplasiagradesiiiiiandcervicalcancerinpatientswithcytologicaldiagnosisofatypicalsquamouscellswhenhighgradeintraepitheliallesionsaschcannotberuledout AT monteiroaparecidacristinasampaio prevalenceofcervicalintraepithelialneoplasiagradesiiiiiandcervicalcancerinpatientswithcytologicaldiagnosisofatypicalsquamouscellswhenhighgradeintraepitheliallesionsaschcannotberuledout |
_version_ |
1756421543065288704 |