Myelodysplastic syndromes (MDS): prognostic factors and scoring systems

OBJECTIVE: To evaluate the score systems of Cassano and Sanz and suggest a new one. DESIGN: Case series. LOCATION: Teaching hospitals: EPM UNIFESP and Faculdade de Medicina de Botucatu. PARTICIPANTS: 59 patients diagnosed from 1979 to 1992. INTERVENTION: Evaluation of clinical-laboratorial data. MEASUREMENT: Statistical comparison, uni and multivariate analysis and actuarial survival curves. RESULTS: Cassano's system divided the patients into high and low risk (p=0.0966) while, Sanz's gave high, intermediate and low risk (p=0.0108). The univariate analysis showed hemoglobin, WBC count, E/M ratio, liver size and blast percentage in BM as statistically significant. The multivariate analysis showed blast percentage in BM (p=0.004) and Hb (p=0.050) as significant. Our system, considering the multivariate analysis data, divided the patients into high, intermediate and low risk (p=0.0038). CONCLUSIONS: Sanz's system was more functional than Cassano's, while ours showed predictive survival value and ease of use in clinical practice.

Bibliographic Details

Main Authors:	Souto,Elizabeth Xisto, Chauffaile,Maria de Lourdes Lopes Ferrari, Moncau,José Eduardo Cajado, Niero-Melo,Lígia, Braga,Gisele Wally, Silva,Maria Regina Regis, Kerbauy,José
Format:	Digital revista
Language:	English
Published:	Associação Paulista de Medicina - APM 1997
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801997000500005
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