Hemolytíc Uremíc Syndrome and SARS-CoV-2 lnfectíon: A Rare Assocíatíon
Abstract Thrombotic microangiopathies (TMA) are rare diseases, with high morbimortality. Among them, atypical hemolytic ure-mic syndrome (HUS), associated with deregulation of alternative complement pathway (genetic/acquired), represents a diagnostic challenge. Characterized by thrombotic microangiopathy, acute renal failure is one of its main features. Etiological/precipitant detection (TMA triggers) is essential, even though about 30% of cases remain idiopathic. There is not a direct diagnostic test, which makes this an exclusion final diagnosis (after primary and secondary causes are ruled-out). Further testing for genetic variations is important for prognostic purposes. We describe the case of a 40 years old woman, whose final diagnostic was an atypical HUS associated with SARS-CoV-2 infection. This case stands out by its rarity. We underline the importance of prompt initial diagnosis and timely target treatment beginning: Eculizumab, the only one available in Portugal at the moment. Plasmapheresis and/or renal replacement therapy must be considered case by case.
| Main Authors: | , , , , , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Sociedade Portuguesa de Medicina Interna
2023
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| Online Access: | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-671X2023000300046 |
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