ANTIMICROBIAL AND SOD-LIKE ACTIVITIES OF N,N′ -BIS(FERROCENYLMETHYLENE)ETHYLENEDIAMINE SCHIFF BASE AND IT’S METAL COMPLEXES

ABSTRACT The synthesized N,N′ -bis(ferrocenylmethylene)ethylenediamine Schiff base and it’s metal complexes were screened in vitro for antimicrobial activity against two Gram-positive ( Staphylococcus aureus ATCC 25923, Bacillus cereus ATCC 7064), four Gram-negative ( Escherichia coli ATCC 25922, Citrobacter koseri DBCC 01, Entorebacter aeruginosa ATCC 13048, Salmonella typhimurium DBCC 02) and antifungal activity against a Candida albicans . MIC values of the compounds ranged from 27 to 533 μg/mL. Compound (5) showed very strong activity against S. aureus with the best MIC (27 μg/mL). The lowest MIC for C. albicans was obtained 107 μg/mL. The superoxide dismutase activity of Schiff base and it’s metal complexes has been measured and discussed. SOD-like activities of bis ferrocenyl Schiff base ligand metal complexes were investigated using NBT. While only the Cu (II) complex showed SOD-like (40 μm IC50) activity, the SOD-like activity value was not determined in the other complex and ligand.

Bibliographic Details

Main Authors:	Özbek,Hülya Avci, Çinar,Seda, Oskay,Mustafa, Aydemİr,Tülİn, Demİrhan,Funda
Format:	Digital revista
Language:	English
Published:	Sociedad Chilena de Química 2021
Online Access:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072021000305237
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