ANTIBACTERIAL AND ENZYME INHIBITION SCREENING OF SOME NEW ACETAMIDE AND AZOMETHINE DERIVATIVES

The synthesis of poly-functional moieties as one unit has been under consideration by the synthetic chemists to search out new potent molecules. 2-Chlorobenzoic acid (1) was converted to 5-(2-chlorophenyl)-1,3,4-Oxadiazol-2-thiol (4) through a series of steps. This nucleophile was attached with different electrophiles, prepared by the reaction of aryl/alkyl amines with 2-bromoacetylbromide, in NaH/DMF to synthesize N-substituted-2-((5-(2-chlorophenyl)-1,3,4-Oxadiazol-2-yl)sulfanyl)acetamide, 7a-f. The molecule 4 was stepped to ethyl ester and carbohydrazide. The carbohydrazide was made to react with aryl carboxaldehydes in methanol to synthesize N'-substituted-2-(5-(2-chlorophenyl)-1,3,4-Oxadiazol-2-ylthio)acetohydrazide, 11a-i. The structures of all the molecules were corroborated through IR, ¹H-NMR and EI-MS spectral data. Both the series were screened for antibacterial and enzyme inhibition activity.

Bibliographic Details

Main Authors:	RASOOL,SHAHID, AZIZ-UR-REHMAN, ABBASI,MUHAMMAD ATHAR, SIDDIQUI,SABAHAT ZAHRA, SHAH,SYED ADNAN ALI, AHMAD,IRSHAD, AFZAL,SAIRA
Format:	Digital revista
Language:	English
Published:	Sociedad Chilena de Química 2015
Online Access:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072015000400014
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