ASYMMETRIC BIS(BIDENTATE) AZINE LIGAND AND TRANSITION METAL COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA-BINDING AND CLEAVAGE STUDIES AND EXTRACTION PROPERTIES FOR SELECTED METALS AND DICHROMATE ANIONS
New bis (bidentate) azine NNN'N' donor ligand was prepared by linking (1Z,1'Z)-1,1'-{propane-1,3-diylbis[oxybenzene-4,1-diyl(1Z)eth-1-yl-1-ylidene]} dihydra-zine to pyridine-2-carbaldehyde. Two kinds of copper(II) and nickel (II) complexes with different stoichiometries were prepared. Reaction of bis(azine) ligand with Cu(II) and Ni(II) chloride with 1:1 molar ratio gave azine complexes with stoichiometry [M(L)Cl2] while 2:1 molar ratio reaction of Cu(II) and Ni(II) chloride with bis(azine) composed binuclear copper complexes with general stoichiometry [M2(L)Cl4]. The structures of both bis-azine ligand and its complexes were identified by elemental analysis, infrared spectra, UV-Vis electronic absorption spectra and magnetic susceptibility measurements, TGA and powder XRD. DNA binding and DNA cleavage activities of the synthesized metal complexes were examined by using UV-vis titration and agarose gel electrophoresis, respectively. The results indicate that all the complexes bind significantly calf thymus DNA and cleavage pBR322 DNA. Furthermore, the complexing properties of the bis-azine ligand toward selected transition metal cations and dichromate anions were also reported.
| Main Authors: | , , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Sociedad Chilena de Química
2012
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| Online Access: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000300004 |
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