Effect of vitamin D3 supplementation on 25 OHD plasma levels in the presence of VDR gene polymorphisms

Effect of vitamin D3 supplementation on 25 OHD plasma levels in the presence of VDR gene polymorphisms

ABSTRACT The objective of this review was to investigate the effect of vitamin D3 supplementation on serum 25-hydroxyvitamin D concentration in individuals with single-nucleotide polymorphisms in the vitamin D receptor gene. The research was conducted on 241 articles found in the PubMed, Scopus, Science Direct, and Cochrane Library databases between November and December 2018. After article screening, three randomized double-blind placebo-controlled clinical trials were identified as eligible for this review. Participants were Australian, Brazilian, and Chinese individuals, who ingested doses of vitamin D3 ranging from 2000 IU to a megadose of 200,000 IU. The presence of the BB/Bb genotype of the BsmI polymorphism and the FokI G allele caused an increase in the serum concentrations of vitamin D after supplementation. Nonetheless, the few studies on this subject are not unanimous in their results. It is possible that differences among populations, sample sizes, doses, and time of supplementation have an impact on data and outcomes.

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Main Authors: Nunes,Ivone Freires de Oliveira Costa, Rogero,Marcelo Macedo, Sousa,Joyce Ramalho, Rosa,Érica Patrícia Cunha, Carvalho,Marcos David Figueiredo de, Oliveira,Francisco Erasmo de, Nascimento,Leopoldo Fabrício Marçal do, Cruz,Maria do Socorro Pires e, Carvalho,Cecilia Maria Resende Gonçalves de
Format: Digital revista
Language:English
Published: Sociedad Chilena de Nutrición, Bromatología y Toxicología 2020
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-75182020000100141
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spelling oai:scielo:S0717-751820200001001412020-02-25Effect of vitamin D3 supplementation on 25 OHD plasma levels in the presence of VDR gene polymorphismsNunes,Ivone Freires de Oliveira CostaRogero,Marcelo MacedoSousa,Joyce RamalhoRosa,Érica Patrícia CunhaCarvalho,Marcos David Figueiredo deOliveira,Francisco Erasmo deNascimento,Leopoldo Fabrício Marçal doCruz,Maria do Socorro Pires eCarvalho,Cecilia Maria Resende Gonçalves de BsmI FokI Randomized clinical trial Vitamin D receptor 25(OH) D ABSTRACT The objective of this review was to investigate the effect of vitamin D3 supplementation on serum 25-hydroxyvitamin D concentration in individuals with single-nucleotide polymorphisms in the vitamin D receptor gene. The research was conducted on 241 articles found in the PubMed, Scopus, Science Direct, and Cochrane Library databases between November and December 2018. After article screening, three randomized double-blind placebo-controlled clinical trials were identified as eligible for this review. Participants were Australian, Brazilian, and Chinese individuals, who ingested doses of vitamin D3 ranging from 2000 IU to a megadose of 200,000 IU. The presence of the BB/Bb genotype of the BsmI polymorphism and the FokI G allele caused an increase in the serum concentrations of vitamin D after supplementation. Nonetheless, the few studies on this subject are not unanimous in their results. It is possible that differences among populations, sample sizes, doses, and time of supplementation have an impact on data and outcomes.info:eu-repo/semantics/openAccessSociedad Chilena de Nutrición, Bromatología y ToxicologíaRevista chilena de nutrición v.47 n.1 20202020-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-75182020000100141en10.4067/S0717-75182020000100141
institution SCIELO
collection OJS
country Chile
countrycode CL
component Revista
access En linea
databasecode rev-scielo-cl
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Nunes,Ivone Freires de Oliveira Costa
Rogero,Marcelo Macedo
Sousa,Joyce Ramalho
Rosa,Érica Patrícia Cunha
Carvalho,Marcos David Figueiredo de
Oliveira,Francisco Erasmo de
Nascimento,Leopoldo Fabrício Marçal do
Cruz,Maria do Socorro Pires e
Carvalho,Cecilia Maria Resende Gonçalves de
spellingShingle Nunes,Ivone Freires de Oliveira Costa
Rogero,Marcelo Macedo
Sousa,Joyce Ramalho
Rosa,Érica Patrícia Cunha
Carvalho,Marcos David Figueiredo de
Oliveira,Francisco Erasmo de
Nascimento,Leopoldo Fabrício Marçal do
Cruz,Maria do Socorro Pires e
Carvalho,Cecilia Maria Resende Gonçalves de
Effect of vitamin D3 supplementation on 25 OHD plasma levels in the presence of VDR gene polymorphisms
author_facet Nunes,Ivone Freires de Oliveira Costa
Rogero,Marcelo Macedo
Sousa,Joyce Ramalho
Rosa,Érica Patrícia Cunha
Carvalho,Marcos David Figueiredo de
Oliveira,Francisco Erasmo de
Nascimento,Leopoldo Fabrício Marçal do
Cruz,Maria do Socorro Pires e
Carvalho,Cecilia Maria Resende Gonçalves de
author_sort Nunes,Ivone Freires de Oliveira Costa
title Effect of vitamin D3 supplementation on 25 OHD plasma levels in the presence of VDR gene polymorphisms
title_short Effect of vitamin D3 supplementation on 25 OHD plasma levels in the presence of VDR gene polymorphisms
title_full Effect of vitamin D3 supplementation on 25 OHD plasma levels in the presence of VDR gene polymorphisms
title_fullStr Effect of vitamin D3 supplementation on 25 OHD plasma levels in the presence of VDR gene polymorphisms
title_full_unstemmed Effect of vitamin D3 supplementation on 25 OHD plasma levels in the presence of VDR gene polymorphisms
title_sort effect of vitamin d3 supplementation on 25 ohd plasma levels in the presence of vdr gene polymorphisms
description ABSTRACT The objective of this review was to investigate the effect of vitamin D3 supplementation on serum 25-hydroxyvitamin D concentration in individuals with single-nucleotide polymorphisms in the vitamin D receptor gene. The research was conducted on 241 articles found in the PubMed, Scopus, Science Direct, and Cochrane Library databases between November and December 2018. After article screening, three randomized double-blind placebo-controlled clinical trials were identified as eligible for this review. Participants were Australian, Brazilian, and Chinese individuals, who ingested doses of vitamin D3 ranging from 2000 IU to a megadose of 200,000 IU. The presence of the BB/Bb genotype of the BsmI polymorphism and the FokI G allele caused an increase in the serum concentrations of vitamin D after supplementation. Nonetheless, the few studies on this subject are not unanimous in their results. It is possible that differences among populations, sample sizes, doses, and time of supplementation have an impact on data and outcomes.
publisher Sociedad Chilena de Nutrición, Bromatología y Toxicología
publishDate 2020
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-75182020000100141
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