Cell cycle related long non-coding RNAs as the critical regulators of breast cancer progression and metastasis
Abstract Cell cycle is one of the main cellular mechanisms involved in tumor progression. Almost all of the active molecular pathways in tumor cells directly or indirectly target the cell cycle progression. Therefore, it is necessary to assess the molecular mechanisms involved in cell cycle regulation in tumor cells. Since, early diagnosis has pivotal role in better cancer management and treatment, it is required to introduce the non-invasive diagnostic markers. Long non-coding RNAs (LncRNAs) have higher stability in body fluids in comparison with mRNAs. Therefore, they can be used as efficient non-invasive markers for the early detection of breast cancer (BCa). In the present review we have summarized all of the reported lncRNAs involved in cell cycle regulation in BCa. It has been reported that lncRNAs mainly affect the cell cycle in G1/S transition through the CCND1/CDK4-6 complex. Present review paves the way of introducing the cell cycle related lncRNAs as efficient markers for the early detection of BCa.
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Sociedad de Biología de Chile
2023
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oai:scielo:S0716-976020230001002012023-03-28Cell cycle related long non-coding RNAs as the critical regulators of breast cancer progression and metastasisZangouei,Amir SadraZangoue,MaliheTaghehchian,NeginZangooie,AlirezaReza Rahimi,HamidSaburi,EhsanSadat Alavi,MahyaMoghbeli,Meysam Breast cancer LncRNAs Cell cycle Liquid biopsy Diagnosis Abstract Cell cycle is one of the main cellular mechanisms involved in tumor progression. Almost all of the active molecular pathways in tumor cells directly or indirectly target the cell cycle progression. Therefore, it is necessary to assess the molecular mechanisms involved in cell cycle regulation in tumor cells. Since, early diagnosis has pivotal role in better cancer management and treatment, it is required to introduce the non-invasive diagnostic markers. Long non-coding RNAs (LncRNAs) have higher stability in body fluids in comparison with mRNAs. Therefore, they can be used as efficient non-invasive markers for the early detection of breast cancer (BCa). In the present review we have summarized all of the reported lncRNAs involved in cell cycle regulation in BCa. It has been reported that lncRNAs mainly affect the cell cycle in G1/S transition through the CCND1/CDK4-6 complex. Present review paves the way of introducing the cell cycle related lncRNAs as efficient markers for the early detection of BCa.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.56 20232023-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602023000100201en10.1186/s40659-022-00411-4 |
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Zangouei,Amir Sadra Zangoue,Malihe Taghehchian,Negin Zangooie,Alireza Reza Rahimi,Hamid Saburi,Ehsan Sadat Alavi,Mahya Moghbeli,Meysam |
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Zangouei,Amir Sadra Zangoue,Malihe Taghehchian,Negin Zangooie,Alireza Reza Rahimi,Hamid Saburi,Ehsan Sadat Alavi,Mahya Moghbeli,Meysam Cell cycle related long non-coding RNAs as the critical regulators of breast cancer progression and metastasis |
author_facet |
Zangouei,Amir Sadra Zangoue,Malihe Taghehchian,Negin Zangooie,Alireza Reza Rahimi,Hamid Saburi,Ehsan Sadat Alavi,Mahya Moghbeli,Meysam |
author_sort |
Zangouei,Amir Sadra |
title |
Cell cycle related long non-coding RNAs as the critical regulators of breast cancer progression and metastasis |
title_short |
Cell cycle related long non-coding RNAs as the critical regulators of breast cancer progression and metastasis |
title_full |
Cell cycle related long non-coding RNAs as the critical regulators of breast cancer progression and metastasis |
title_fullStr |
Cell cycle related long non-coding RNAs as the critical regulators of breast cancer progression and metastasis |
title_full_unstemmed |
Cell cycle related long non-coding RNAs as the critical regulators of breast cancer progression and metastasis |
title_sort |
cell cycle related long non-coding rnas as the critical regulators of breast cancer progression and metastasis |
description |
Abstract Cell cycle is one of the main cellular mechanisms involved in tumor progression. Almost all of the active molecular pathways in tumor cells directly or indirectly target the cell cycle progression. Therefore, it is necessary to assess the molecular mechanisms involved in cell cycle regulation in tumor cells. Since, early diagnosis has pivotal role in better cancer management and treatment, it is required to introduce the non-invasive diagnostic markers. Long non-coding RNAs (LncRNAs) have higher stability in body fluids in comparison with mRNAs. Therefore, they can be used as efficient non-invasive markers for the early detection of breast cancer (BCa). In the present review we have summarized all of the reported lncRNAs involved in cell cycle regulation in BCa. It has been reported that lncRNAs mainly affect the cell cycle in G1/S transition through the CCND1/CDK4-6 complex. Present review paves the way of introducing the cell cycle related lncRNAs as efficient markers for the early detection of BCa. |
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Sociedad de Biología de Chile |
publishDate |
2023 |
url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602023000100201 |
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