Thyroid abnormalities in systemic lupus erythematosus: a study in 100 Brazilian patients
INTRODUCTION: the association of thyroid abnormalities with systemic lupus erythematosus (SLE) is not well established. OBJECTIVE: to study the prevalence of thyroid dysfunction in hundred lupus patients and evaluate a possible association between thyroid dysfunction and SLE disease activity. METHODS: a total of one hundred patients with SLE underwent assessment for clinical and laboratorial thyroid abnormalities. Clinical activity was assessed using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). RESULTS: seventeen patients (17%) had abnormal thyroid function by laboratory testing, which included ten patients (10%) with subclinical hypothyroidism, two patients (2%) with subclinical hyperthyroidism, four patients (4%) with primary hypothyroidism and one patient with serum thyroxine below the normal range. Regarding antithyroid antibodies, six patients were positive, as follows: four (4%) for antiperoxidase, one (1%) for antithyroglobulin and one (1%) for both antibodies. SLE disease activity was not significantly different between groups, regardless of the presence of thyroid dysfunction. CONCLUSION: these results show that thyroid abnormalities are frequently found in SLE patients. However, it does not appear to be an association between thyroid abnormalities and SLE clinical disease activity.
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Sociedade Brasileira de Reumatologia
2006
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oai:scielo:S0482-500420060006000032007-02-07Thyroid abnormalities in systemic lupus erythematosus: a study in 100 Brazilian patientsKakehasi,Adriana MariaDias,Vinícius NavesDuarte,Juliana EliasLanna,Cristina Costa DuarteCarvalho,Marco Antônio Parreiras de systemic lupus erythematosus autoimmunity autoimmune thyroiditis hypothyroidism hyperthyroidism INTRODUCTION: the association of thyroid abnormalities with systemic lupus erythematosus (SLE) is not well established. OBJECTIVE: to study the prevalence of thyroid dysfunction in hundred lupus patients and evaluate a possible association between thyroid dysfunction and SLE disease activity. METHODS: a total of one hundred patients with SLE underwent assessment for clinical and laboratorial thyroid abnormalities. Clinical activity was assessed using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). RESULTS: seventeen patients (17%) had abnormal thyroid function by laboratory testing, which included ten patients (10%) with subclinical hypothyroidism, two patients (2%) with subclinical hyperthyroidism, four patients (4%) with primary hypothyroidism and one patient with serum thyroxine below the normal range. Regarding antithyroid antibodies, six patients were positive, as follows: four (4%) for antiperoxidase, one (1%) for antithyroglobulin and one (1%) for both antibodies. SLE disease activity was not significantly different between groups, regardless of the presence of thyroid dysfunction. CONCLUSION: these results show that thyroid abnormalities are frequently found in SLE patients. However, it does not appear to be an association between thyroid abnormalities and SLE clinical disease activity.info:eu-repo/semantics/openAccessSociedade Brasileira de ReumatologiaRevista Brasileira de Reumatologia v.46 n.6 20062006-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042006000600003en10.1590/S0482-50042006000600003 |
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Kakehasi,Adriana Maria Dias,Vinícius Naves Duarte,Juliana Elias Lanna,Cristina Costa Duarte Carvalho,Marco Antônio Parreiras de |
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Kakehasi,Adriana Maria Dias,Vinícius Naves Duarte,Juliana Elias Lanna,Cristina Costa Duarte Carvalho,Marco Antônio Parreiras de Thyroid abnormalities in systemic lupus erythematosus: a study in 100 Brazilian patients |
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Kakehasi,Adriana Maria Dias,Vinícius Naves Duarte,Juliana Elias Lanna,Cristina Costa Duarte Carvalho,Marco Antônio Parreiras de |
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Kakehasi,Adriana Maria |
title |
Thyroid abnormalities in systemic lupus erythematosus: a study in 100 Brazilian patients |
title_short |
Thyroid abnormalities in systemic lupus erythematosus: a study in 100 Brazilian patients |
title_full |
Thyroid abnormalities in systemic lupus erythematosus: a study in 100 Brazilian patients |
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Thyroid abnormalities in systemic lupus erythematosus: a study in 100 Brazilian patients |
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Thyroid abnormalities in systemic lupus erythematosus: a study in 100 Brazilian patients |
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thyroid abnormalities in systemic lupus erythematosus: a study in 100 brazilian patients |
description |
INTRODUCTION: the association of thyroid abnormalities with systemic lupus erythematosus (SLE) is not well established. OBJECTIVE: to study the prevalence of thyroid dysfunction in hundred lupus patients and evaluate a possible association between thyroid dysfunction and SLE disease activity. METHODS: a total of one hundred patients with SLE underwent assessment for clinical and laboratorial thyroid abnormalities. Clinical activity was assessed using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). RESULTS: seventeen patients (17%) had abnormal thyroid function by laboratory testing, which included ten patients (10%) with subclinical hypothyroidism, two patients (2%) with subclinical hyperthyroidism, four patients (4%) with primary hypothyroidism and one patient with serum thyroxine below the normal range. Regarding antithyroid antibodies, six patients were positive, as follows: four (4%) for antiperoxidase, one (1%) for antithyroglobulin and one (1%) for both antibodies. SLE disease activity was not significantly different between groups, regardless of the presence of thyroid dysfunction. CONCLUSION: these results show that thyroid abnormalities are frequently found in SLE patients. However, it does not appear to be an association between thyroid abnormalities and SLE clinical disease activity. |
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Sociedade Brasileira de Reumatologia |
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2006 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042006000600003 |
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