Congenital solitary reticulohistiocytosis (Hashimoto - Pritzker)
Abstract Congenital and self-healing Hashimoto-Pritzker reticulohistiocytosis is the benign variant of the Langerhans cell histiocytosis (LCH) group. It is characterized by multiple skin lesions (congenital or appearing during the first days after birth), without systemic manifestations and spontaneous resolution in days to months. The authors report the case of a boy with a single congenital leg skin lesion, a rare disease variant. Through histopathology, a dense skin infiltration of S100 protein-, CD1a-, CD207-immunomarked cells was found. KI67 index was high (62%). A complete spontaneous resolution occurred 07 days after the biopsy (25 days after birth). Monolesional disease, distal limb lesion, absence of lesions in the mucous membrane or seborrheic area, and less than 25 percent of LCs with Birbeck granules were said to be possible clues for a favorable prognosis in LCs histiocytosis. But, as a precautionary measure, the child will be followed up until at least 2 years of age.
Main Authors: | , , , , |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Sociedade Brasileira de Dermatologia
2022
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000600778 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
oai:scielo:S0365-05962022000600778 |
---|---|
record_format |
ojs |
spelling |
oai:scielo:S0365-059620220006007782022-11-10Congenital solitary reticulohistiocytosis (Hashimoto - Pritzker)Lima,Luciana Prates Nogueira deAmorim,Carolina VizaMarinho,Rachel MartinsCintra,Maria LetíciaSouza,Elemir Macedo de Histiocytoma Immunohistochemistry Pathology Abstract Congenital and self-healing Hashimoto-Pritzker reticulohistiocytosis is the benign variant of the Langerhans cell histiocytosis (LCH) group. It is characterized by multiple skin lesions (congenital or appearing during the first days after birth), without systemic manifestations and spontaneous resolution in days to months. The authors report the case of a boy with a single congenital leg skin lesion, a rare disease variant. Through histopathology, a dense skin infiltration of S100 protein-, CD1a-, CD207-immunomarked cells was found. KI67 index was high (62%). A complete spontaneous resolution occurred 07 days after the biopsy (25 days after birth). Monolesional disease, distal limb lesion, absence of lesions in the mucous membrane or seborrheic area, and less than 25 percent of LCs with Birbeck granules were said to be possible clues for a favorable prognosis in LCs histiocytosis. But, as a precautionary measure, the child will be followed up until at least 2 years of age.info:eu-repo/semantics/openAccessSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia v.97 n.6 20222022-11-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000600778en10.1016/j.abd.2022.01.005 |
institution |
SCIELO |
collection |
OJS |
country |
Brasil |
countrycode |
BR |
component |
Revista |
access |
En linea |
databasecode |
rev-scielo-br |
tag |
revista |
region |
America del Sur |
libraryname |
SciELO |
language |
English |
format |
Digital |
author |
Lima,Luciana Prates Nogueira de Amorim,Carolina Viza Marinho,Rachel Martins Cintra,Maria Letícia Souza,Elemir Macedo de |
spellingShingle |
Lima,Luciana Prates Nogueira de Amorim,Carolina Viza Marinho,Rachel Martins Cintra,Maria Letícia Souza,Elemir Macedo de Congenital solitary reticulohistiocytosis (Hashimoto - Pritzker) |
author_facet |
Lima,Luciana Prates Nogueira de Amorim,Carolina Viza Marinho,Rachel Martins Cintra,Maria Letícia Souza,Elemir Macedo de |
author_sort |
Lima,Luciana Prates Nogueira de |
title |
Congenital solitary reticulohistiocytosis (Hashimoto - Pritzker) |
title_short |
Congenital solitary reticulohistiocytosis (Hashimoto - Pritzker) |
title_full |
Congenital solitary reticulohistiocytosis (Hashimoto - Pritzker) |
title_fullStr |
Congenital solitary reticulohistiocytosis (Hashimoto - Pritzker) |
title_full_unstemmed |
Congenital solitary reticulohistiocytosis (Hashimoto - Pritzker) |
title_sort |
congenital solitary reticulohistiocytosis (hashimoto - pritzker) |
description |
Abstract Congenital and self-healing Hashimoto-Pritzker reticulohistiocytosis is the benign variant of the Langerhans cell histiocytosis (LCH) group. It is characterized by multiple skin lesions (congenital or appearing during the first days after birth), without systemic manifestations and spontaneous resolution in days to months. The authors report the case of a boy with a single congenital leg skin lesion, a rare disease variant. Through histopathology, a dense skin infiltration of S100 protein-, CD1a-, CD207-immunomarked cells was found. KI67 index was high (62%). A complete spontaneous resolution occurred 07 days after the biopsy (25 days after birth). Monolesional disease, distal limb lesion, absence of lesions in the mucous membrane or seborrheic area, and less than 25 percent of LCs with Birbeck granules were said to be possible clues for a favorable prognosis in LCs histiocytosis. But, as a precautionary measure, the child will be followed up until at least 2 years of age. |
publisher |
Sociedade Brasileira de Dermatologia |
publishDate |
2022 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000600778 |
work_keys_str_mv |
AT limalucianapratesnogueirade congenitalsolitaryreticulohistiocytosishashimotopritzker AT amorimcarolinaviza congenitalsolitaryreticulohistiocytosishashimotopritzker AT marinhorachelmartins congenitalsolitaryreticulohistiocytosishashimotopritzker AT cintramarialeticia congenitalsolitaryreticulohistiocytosishashimotopritzker AT souzaelemirmacedode congenitalsolitaryreticulohistiocytosishashimotopritzker |
_version_ |
1756471827882835968 |