Refractory pemphigus vulgaris treated with rituximab and mycophenolate mofetil
The main treatment for pemphigus vulgaris are systemic corticosteroids and immunosuppressive agents, but due to adverse reactions and therapeutic failure, new drugs such as rituximab and mycophenolate mofetil have been used. In this case report are described two cases of severe pemphigus vulgaris refractory to various treatments, with resolution after use of rituximab and mycophenolate mofetil, associated with corticosteroids. A higher-than-usual dose of rituximab was employed, without the occurrence of serious adverse reactions. Mycophenolate mofetil was added as adjunctive therapy due to lack of response to azathioprine.
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Sociedade Brasileira de Dermatologia
2014
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oai:scielo:S0365-059620140006009802015-03-25Refractory pemphigus vulgaris treated with rituximab and mycophenolate mofetilBiot,Stephanie Del Rio NavarreteFranco,Joanna Pimenta de AraujoLima,Ricardo BarbosaPereira,Henrique Novo CostaMarques,Luiz Paulo JoséMartins,Carlos José Antibodies, monoclonal Immunosuppressive agents Pemphigus The main treatment for pemphigus vulgaris are systemic corticosteroids and immunosuppressive agents, but due to adverse reactions and therapeutic failure, new drugs such as rituximab and mycophenolate mofetil have been used. In this case report are described two cases of severe pemphigus vulgaris refractory to various treatments, with resolution after use of rituximab and mycophenolate mofetil, associated with corticosteroids. A higher-than-usual dose of rituximab was employed, without the occurrence of serious adverse reactions. Mycophenolate mofetil was added as adjunctive therapy due to lack of response to azathioprine.info:eu-repo/semantics/openAccessSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia v.89 n.6 20142014-12-01info:eu-repo/semantics/reporttext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000600980en10.1590/abd1806-4841.20143128 |
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Biot,Stephanie Del Rio Navarrete Franco,Joanna Pimenta de Araujo Lima,Ricardo Barbosa Pereira,Henrique Novo Costa Marques,Luiz Paulo José Martins,Carlos José |
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Biot,Stephanie Del Rio Navarrete Franco,Joanna Pimenta de Araujo Lima,Ricardo Barbosa Pereira,Henrique Novo Costa Marques,Luiz Paulo José Martins,Carlos José Refractory pemphigus vulgaris treated with rituximab and mycophenolate mofetil |
| author_facet |
Biot,Stephanie Del Rio Navarrete Franco,Joanna Pimenta de Araujo Lima,Ricardo Barbosa Pereira,Henrique Novo Costa Marques,Luiz Paulo José Martins,Carlos José |
| author_sort |
Biot,Stephanie Del Rio Navarrete |
| title |
Refractory pemphigus vulgaris treated with rituximab and mycophenolate mofetil |
| title_short |
Refractory pemphigus vulgaris treated with rituximab and mycophenolate mofetil |
| title_full |
Refractory pemphigus vulgaris treated with rituximab and mycophenolate mofetil |
| title_fullStr |
Refractory pemphigus vulgaris treated with rituximab and mycophenolate mofetil |
| title_full_unstemmed |
Refractory pemphigus vulgaris treated with rituximab and mycophenolate mofetil |
| title_sort |
refractory pemphigus vulgaris treated with rituximab and mycophenolate mofetil |
| description |
The main treatment for pemphigus vulgaris are systemic corticosteroids and immunosuppressive agents, but due to adverse reactions and therapeutic failure, new drugs such as rituximab and mycophenolate mofetil have been used. In this case report are described two cases of severe pemphigus vulgaris refractory to various treatments, with resolution after use of rituximab and mycophenolate mofetil, associated with corticosteroids. A higher-than-usual dose of rituximab was employed, without the occurrence of serious adverse reactions. Mycophenolate mofetil was added as adjunctive therapy due to lack of response to azathioprine. |
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Sociedade Brasileira de Dermatologia |
| publishDate |
2014 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000600980 |
| work_keys_str_mv |
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