Alteraciones Hematológicas Inducidas por el Veneno del Escorpión Tityus discrepans en Ratones
In order to evidence the hematological changes induced by the venom of the scorpion Tityus discrepans, a sublethal dose of Tityus discrepans venom (Tdv, 1 µg/g) in a total volume of 0.1 mL was intraperitoneally injected in BALB/c female mice (20±2 g; n=20). Mice were anesthetized and blood samples were withdrawn by cardiocentesis at 0 h, 3 h, 6 h, and 12 h after Tdv administration. Hematologic analyses were performed by routine procedures. A significant (p<0.05) increase in hematocrit, hemoglobin concentration and total protein concentration was observed at 3 h and 6 h, possibly due to dehydration, splenic contraction and acute-phase protein induction. The red blood cell count in envenomed mice was significantly (p<0.05) higher in comparison with the control only at 12 h. Tityus discrepans venom caused neutrophilia and lymphopenia probably as a result of catecholamine release, without significant (p>0.05) changes in absolute leukocyte count. Neither platelets number nor hematimetric indexes significantly (p>0.05) changed. Altogether, these results suggest that Tdv administration induces alterations in the hematologic profile in mice.
| Main Authors: | , , , , , |
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| Format: | Digital revista |
| Language: | Spanish / Castilian |
| Published: |
Revista de la Facultad de Ciencias Veterinarias. Universidad Central de Venezuela.
2015
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| Online Access: | http://ve.scielo.org/scielo.php?script=sci_arttext&pid=S0258-65762015000100002 |
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