Metabolic, inflammatory and oxidative stress markers in the nitric oxide variation of hemodialysis subjects
Abstract Introduction: Oxidative stress markers such as nitric oxide (NO) have been investigated in hemodialysis (HD). Objective: Evaluate the association of NO variation with adiposity indicators, metabolic, inflammatory and oxidative stress markers in individuals to HD. Methods: Cross-sectional study with 85 subjects on HD treatment (≥ 18 years). The clinical-nutritional status was evaluated through subjective global assessment modified (SGAm), anthropometric measurements and body composition. Dietary intake was evaluated using a food frequency questionnaire. Metabolic markers were obtained from medical records. Inflammatory markers (IL-6 and IL-10) and oxidative stress, (TACs), (SOD), (GST), (MDA) and NO were determined using standardized protocols. Results: Those individuals with a high concentration of NO (> 4.32 μmol/L) had lower values for SGAm score (p = 0.012) and higher iron values (p = 0.050), Fe saturation (p = 0.037) and triacylglycerol (p = 0.003). The same subjects still had lower consumption of copper (p = 0.026), manganese (p = 0.035), vitamin E (p = 0.050), ω3 (p = 0.021) and ω6 (p = 0.020). In a multiple regression model, concentrations of ferritin, triacylglycerol, IL6 and SOD contributed to a 54.8% increase in NO concentrations, whereas triacylglycerol and SOD concentrations were independent factors for NO variation (p < 0.001). Conclusions: The clinical and nutritional status as well as intake of nutrients with antioxidant properties (Cu, Zn, Mn, vitamin C and ω3) appears to modulate the variation of NO in this population.
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2018
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oai:scielo:S0212-161120180001001762021-03-11Metabolic, inflammatory and oxidative stress markers in the nitric oxide variation of hemodialysis subjectsSantos-Epifânio,Andreza-P.Balbino,Karka-P.de-P.-Jorge,MônicaR.-Ribeiro,Sônia-M.B.-Moreira,Ana-VládiaOliveira,Jerusa-M.Oliveira,Leandro-L.M.-Hermsdorff,Helen-Hermana Reactive nitrogen species Inflammation Superoxide dismutase Food intake End-stage renal disease Abstract Introduction: Oxidative stress markers such as nitric oxide (NO) have been investigated in hemodialysis (HD). Objective: Evaluate the association of NO variation with adiposity indicators, metabolic, inflammatory and oxidative stress markers in individuals to HD. Methods: Cross-sectional study with 85 subjects on HD treatment (≥ 18 years). The clinical-nutritional status was evaluated through subjective global assessment modified (SGAm), anthropometric measurements and body composition. Dietary intake was evaluated using a food frequency questionnaire. Metabolic markers were obtained from medical records. Inflammatory markers (IL-6 and IL-10) and oxidative stress, (TACs), (SOD), (GST), (MDA) and NO were determined using standardized protocols. Results: Those individuals with a high concentration of NO (> 4.32 μmol/L) had lower values for SGAm score (p = 0.012) and higher iron values (p = 0.050), Fe saturation (p = 0.037) and triacylglycerol (p = 0.003). The same subjects still had lower consumption of copper (p = 0.026), manganese (p = 0.035), vitamin E (p = 0.050), ω3 (p = 0.021) and ω6 (p = 0.020). In a multiple regression model, concentrations of ferritin, triacylglycerol, IL6 and SOD contributed to a 54.8% increase in NO concentrations, whereas triacylglycerol and SOD concentrations were independent factors for NO variation (p < 0.001). Conclusions: The clinical and nutritional status as well as intake of nutrients with antioxidant properties (Cu, Zn, Mn, vitamin C and ω3) appears to modulate the variation of NO in this population.Grupo AránNutrición Hospitalaria v.35 n.1 20182018-02-01journal articletext/htmlhttp://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112018000100176en |
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Santos-Epifânio,Andreza-P. Balbino,Karka-P. de-P.-Jorge,Mônica R.-Ribeiro,Sônia-M. B.-Moreira,Ana-Vládia Oliveira,Jerusa-M. Oliveira,Leandro-L. M.-Hermsdorff,Helen-Hermana |
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Santos-Epifânio,Andreza-P. Balbino,Karka-P. de-P.-Jorge,Mônica R.-Ribeiro,Sônia-M. B.-Moreira,Ana-Vládia Oliveira,Jerusa-M. Oliveira,Leandro-L. M.-Hermsdorff,Helen-Hermana Metabolic, inflammatory and oxidative stress markers in the nitric oxide variation of hemodialysis subjects |
| author_facet |
Santos-Epifânio,Andreza-P. Balbino,Karka-P. de-P.-Jorge,Mônica R.-Ribeiro,Sônia-M. B.-Moreira,Ana-Vládia Oliveira,Jerusa-M. Oliveira,Leandro-L. M.-Hermsdorff,Helen-Hermana |
| author_sort |
Santos-Epifânio,Andreza-P. |
| title |
Metabolic, inflammatory and oxidative stress markers in the nitric oxide variation of hemodialysis subjects |
| title_short |
Metabolic, inflammatory and oxidative stress markers in the nitric oxide variation of hemodialysis subjects |
| title_full |
Metabolic, inflammatory and oxidative stress markers in the nitric oxide variation of hemodialysis subjects |
| title_fullStr |
Metabolic, inflammatory and oxidative stress markers in the nitric oxide variation of hemodialysis subjects |
| title_full_unstemmed |
Metabolic, inflammatory and oxidative stress markers in the nitric oxide variation of hemodialysis subjects |
| title_sort |
metabolic, inflammatory and oxidative stress markers in the nitric oxide variation of hemodialysis subjects |
| description |
Abstract Introduction: Oxidative stress markers such as nitric oxide (NO) have been investigated in hemodialysis (HD). Objective: Evaluate the association of NO variation with adiposity indicators, metabolic, inflammatory and oxidative stress markers in individuals to HD. Methods: Cross-sectional study with 85 subjects on HD treatment (≥ 18 years). The clinical-nutritional status was evaluated through subjective global assessment modified (SGAm), anthropometric measurements and body composition. Dietary intake was evaluated using a food frequency questionnaire. Metabolic markers were obtained from medical records. Inflammatory markers (IL-6 and IL-10) and oxidative stress, (TACs), (SOD), (GST), (MDA) and NO were determined using standardized protocols. Results: Those individuals with a high concentration of NO (> 4.32 μmol/L) had lower values for SGAm score (p = 0.012) and higher iron values (p = 0.050), Fe saturation (p = 0.037) and triacylglycerol (p = 0.003). The same subjects still had lower consumption of copper (p = 0.026), manganese (p = 0.035), vitamin E (p = 0.050), ω3 (p = 0.021) and ω6 (p = 0.020). In a multiple regression model, concentrations of ferritin, triacylglycerol, IL6 and SOD contributed to a 54.8% increase in NO concentrations, whereas triacylglycerol and SOD concentrations were independent factors for NO variation (p < 0.001). Conclusions: The clinical and nutritional status as well as intake of nutrients with antioxidant properties (Cu, Zn, Mn, vitamin C and ω3) appears to modulate the variation of NO in this population. |
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Grupo Arán |
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2018 |
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http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112018000100176 |
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