Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins

Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins

Copper(II) complexes of the Schiff base ligands 2-((5-nitrofuran-2-yl)methyleneamino)phenol (HL1) and 2-(4-nitrobenzylideneamino)phenol (HL2) were prepared and characterized using physicochemical and spectroscopic techniques. In these complexes the Schiff base ligands acted as a bidentate donor bound to Cu2+ through the oxygen and nitrogen atoms in the deprotonated form. The electron paramagnetic resonance spectra, carried out on [CuCl(L1)(phen)].0.5H2O and [CuCl(L2)(phen)].2H2O complexes, showed the presence of only mononuclear forms. The Cu2+ complexes and ligands were evaluated for their in vitro trypanocidal activity. The complex [CuCl(L1)(phen)].0.5H2O was more active than the free Schiff base and also presented a superior effect to benznidazole, the reference drug. The antiproliferative activity of the Schiff bases and Cu2+ complexes were evaluated for their effect on seven tumor cell lines and showed a cytostatic and in some cases a cytotoxic effect. These compounds also presented binding properties to deoxyribonucleic acid (DNA) and moderate ability to quench the intrinsic fluorescence of albumins.

Saved in:
Bibliographic Details
Main Authors: Martins,Darliane A., Bomfim Filho,Lucius F., Silva,Cleiton M. da, Fátima,Ângelo de, Louro,Sonia R. W., Batista,Denise G. J., Soeiro,Maria de Nazaré C., Carvalho,João Ernesto de, Teixeira,Letícia R.
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Química 2017
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000100087
Tags: Add Tag
No Tags, Be the first to tag this record!
id oai:scielo:S0103-50532017000100087
record_format ojs
spelling oai:scielo:S0103-505320170001000872017-01-05Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and AlbuminsMartins,Darliane A.Bomfim Filho,Lucius F.Silva,Cleiton M. daFátima,Ângelo deLouro,Sonia R. W.Batista,Denise G. J.Soeiro,Maria de Nazaré C.Carvalho,João Ernesto deTeixeira,Letícia R. Schiff base copper(II) complexes biological activity DNA albumin Copper(II) complexes of the Schiff base ligands 2-((5-nitrofuran-2-yl)methyleneamino)phenol (HL1) and 2-(4-nitrobenzylideneamino)phenol (HL2) were prepared and characterized using physicochemical and spectroscopic techniques. In these complexes the Schiff base ligands acted as a bidentate donor bound to Cu2+ through the oxygen and nitrogen atoms in the deprotonated form. The electron paramagnetic resonance spectra, carried out on [CuCl(L1)(phen)].0.5H2O and [CuCl(L2)(phen)].2H2O complexes, showed the presence of only mononuclear forms. The Cu2+ complexes and ligands were evaluated for their in vitro trypanocidal activity. The complex [CuCl(L1)(phen)].0.5H2O was more active than the free Schiff base and also presented a superior effect to benznidazole, the reference drug. The antiproliferative activity of the Schiff bases and Cu2+ complexes were evaluated for their effect on seven tumor cell lines and showed a cytostatic and in some cases a cytotoxic effect. These compounds also presented binding properties to deoxyribonucleic acid (DNA) and moderate ability to quench the intrinsic fluorescence of albumins.info:eu-repo/semantics/openAccessSociedade Brasileira de QuímicaJournal of the Brazilian Chemical Society v.28 n.1 20172017-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000100087en10.5935/0103-5053.20160150
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Martins,Darliane A.
Bomfim Filho,Lucius F.
Silva,Cleiton M. da
Fátima,Ângelo de
Louro,Sonia R. W.
Batista,Denise G. J.
Soeiro,Maria de Nazaré C.
Carvalho,João Ernesto de
Teixeira,Letícia R.
spellingShingle Martins,Darliane A.
Bomfim Filho,Lucius F.
Silva,Cleiton M. da
Fátima,Ângelo de
Louro,Sonia R. W.
Batista,Denise G. J.
Soeiro,Maria de Nazaré C.
Carvalho,João Ernesto de
Teixeira,Letícia R.
Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins
author_facet Martins,Darliane A.
Bomfim Filho,Lucius F.
Silva,Cleiton M. da
Fátima,Ângelo de
Louro,Sonia R. W.
Batista,Denise G. J.
Soeiro,Maria de Nazaré C.
Carvalho,João Ernesto de
Teixeira,Letícia R.
author_sort Martins,Darliane A.
title Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins
title_short Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins
title_full Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins
title_fullStr Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins
title_full_unstemmed Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins
title_sort copper(ii) nitroaromatic schiff base complexes: synthesis, biological activity and their interaction with dna and albumins
description Copper(II) complexes of the Schiff base ligands 2-((5-nitrofuran-2-yl)methyleneamino)phenol (HL1) and 2-(4-nitrobenzylideneamino)phenol (HL2) were prepared and characterized using physicochemical and spectroscopic techniques. In these complexes the Schiff base ligands acted as a bidentate donor bound to Cu2+ through the oxygen and nitrogen atoms in the deprotonated form. The electron paramagnetic resonance spectra, carried out on [CuCl(L1)(phen)].0.5H2O and [CuCl(L2)(phen)].2H2O complexes, showed the presence of only mononuclear forms. The Cu2+ complexes and ligands were evaluated for their in vitro trypanocidal activity. The complex [CuCl(L1)(phen)].0.5H2O was more active than the free Schiff base and also presented a superior effect to benznidazole, the reference drug. The antiproliferative activity of the Schiff bases and Cu2+ complexes were evaluated for their effect on seven tumor cell lines and showed a cytostatic and in some cases a cytotoxic effect. These compounds also presented binding properties to deoxyribonucleic acid (DNA) and moderate ability to quench the intrinsic fluorescence of albumins.
publisher Sociedade Brasileira de Química
publishDate 2017
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000100087
work_keys_str_mv AT martinsdarlianea copperiinitroaromaticschiffbasecomplexessynthesisbiologicalactivityandtheirinteractionwithdnaandalbumins
AT bomfimfilholuciusf copperiinitroaromaticschiffbasecomplexessynthesisbiologicalactivityandtheirinteractionwithdnaandalbumins
AT silvacleitonmda copperiinitroaromaticschiffbasecomplexessynthesisbiologicalactivityandtheirinteractionwithdnaandalbumins
AT fatimaangelode copperiinitroaromaticschiffbasecomplexessynthesisbiologicalactivityandtheirinteractionwithdnaandalbumins
AT lourosoniarw copperiinitroaromaticschiffbasecomplexessynthesisbiologicalactivityandtheirinteractionwithdnaandalbumins
AT batistadenisegj copperiinitroaromaticschiffbasecomplexessynthesisbiologicalactivityandtheirinteractionwithdnaandalbumins
AT soeiromariadenazarec copperiinitroaromaticschiffbasecomplexessynthesisbiologicalactivityandtheirinteractionwithdnaandalbumins
AT carvalhojoaoernestode copperiinitroaromaticschiffbasecomplexessynthesisbiologicalactivityandtheirinteractionwithdnaandalbumins
AT teixeiraleticiar copperiinitroaromaticschiffbasecomplexessynthesisbiologicalactivityandtheirinteractionwithdnaandalbumins
_version_ 1756403671650795520

Similar Items