Reactivity of 5a,6-anhydrotetracycline platinum(II) complex with biological nucleophiles: a theoretical study
This paper describes a theoretical analysis of the interaction between 5a,6-anhydrotetracycline platinum(II) complex (AHTC-Pt) and some biological nucleophiles; adenine (A), guanine (G), cysteine (Cys) and methionine (Met). The aquated species [Pt(AHTC)Cl(H2O)]+ was taken as reagent for the processes studied here. For DNA bases (A and G), the calculated values for ΔGa,aq at the B3LYP/6-311+G(2d,p) level were 21.7 and 20.7 kcal mol-1 for interaction with A and G, respectively, which are in accordance with the expected behavior of faster process involving G. These values are higher than the experimental activation energy for the parent compound cisplatin (18.5 kcal mol-1 for interaction with G). For the process involving the amino-acids, the barriers were 17.6 (Cys) and 18.5 kcal mol-1 (Met), which are lower than the observed values for cisplatin (20.5 and 20.2 kcal mol-1, respectively). These outcomes show that AHTC-Pt hybrid complex may be considered a promising lead compound in the development of novel anticancer drugs based on platinum complex.
Main Authors: | , , , |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Sociedade Brasileira de Química
2008
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000800002 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|