Influence of tramadol on functional recovery of acute spinal cord injury in rats
Abstract Purpose: To evaluate the influence tramadol on functional recovery of acute spinal cord injury in rats. Methods: Ten rats were divided into two groups (n = 5). All animals were submitted by a laminectomy and spinal cord injury at eighth thoracic vertebra. In control group, the rats didn’t receive any analgesic. In tramadol group, the rats received tramadol 4mg/Kg at 12/12h until 5 days by subcutaneous. Animals were following by fourteen days. Was evaluated the Basso, Beattie, Bresnahan scale (locomotor evaluation) and Rat Grimace Scale (pain evaluation) at four periods. Results: There no difference between the groups in locomotor evaluation in all periods evaluated (p>0.05) and in both groups there was a partial recover of function. The tramadol group show a lower pain levels at the first, third and seventh postoperatively days when comparing to the control group. Conclusion: The tramadol as an analgesic agent don’t influence on functional recovery of acute spinal cord injury in rats
Main Authors: | Chaves,Rosa Helena de Figueiredo, Souza,Celice Cordeiro de, Furlaneto,Ismari Perini, Teixeira,Renan Kleber Costa, Oliveira,Carolina Pinheiro de, Rodrigues,Emanuelle de Matos, Santos,Daniel Arthur Santos dos, Silva,Renata Cunha, Penha,Nelson Elias Abrahão da, Lima,Ana Rita de |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2018
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018001201087 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Contribution to the study of the spinal cord changes during experimental model of the acute spinal cord injury
by: Leal Filho,Manoel Baldoino
Published: (2005) -
SYSTEMATIC REVIEW OF RECOVERY OF SPINAL CORD INJURY WITH ANTIOXIDANT THERAPY
by: KOFF,MARCO ANTONIO EDUARDO, et al.
Published: (2017) -
Spinal cord regeneration: the action of neurotrophin-3 in spinal cord injury in rats
by: Narazaki,Douglas Kenji, et al.
Published: (2006) -
Evaluation of the effects of erythropoietin and interleukin-6 in rats submitted to acute spinal cord injury
by: Barros,Alderico Girão Campos de, et al.
Published: (2019) -
Therapeutic approaches for spinal cord injury
by: Cristante,Alexandre Fogaça, et al.
Published: (2012)