The effects of aqueous extract of babassu (Orbignya phalerata) on the pleura and lung parenchyma in rats

PURPOSE: To evaluate macro and microscopically, changes following the use of the aqueous extract of babassu (Orbignya phalerata) in the lung parenchyma and pleura of rats. METHODS: Sixty adult male rats with average weight of 350 g, were randomized into two groups of 30 animals (experimental and control) further divided into sub-groups of 10 to be sacrificed at 48 h, 72 h and 21 days. The substance was injected into the right pleura of the animals. RESULTS: There was intense pleuropulmonary macroscopic reaction with statistically significant differences between groups respectively (p<0.05, p<0.02, p<0.03). Microscopically, no statistically significant difference was evident (p>0.05). CONCLUSION: The aqueous extract of babassu (Orbignya phalerata) was found to be highly irritating to the pleura and lung of rats, evidenced macroscopically by numerous adhesions and inflammation while no major changes were evident microscopically.

Bibliographic Details

Main Authors:	Amorim,Elias, Saad Junior,Roberto, Salgado Filho,Natalino, Melo,George Castro Figueira de, Silva,Gyl Eanes Barros, Santos,Rennan Abud Pinheiro, Marchi,Danilo Dallago de, Carli,Ricardo Comunello de, Malafaia,Osvaldo, Ribas-Filho,Jurandir
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2016
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000400243
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