Closed head injury in rats: histopathological aspects in an experimental weight drop model

Closed head injury in rats: histopathological aspects in an experimental weight drop model

PURPOSE: To study histopathological findings due to a model of closed head injury by weight loss in rats. METHODS: A platform was used to induce closed cranial lesion controlled by weight loss with a known and predefined energy. 25 male Wistar rats (Rattus novergicus albinus) were divided in five equal groups which received different cranial impact energy levels: G1, G2, G3 and G4 with 0.234J, 0.5J, 0.762J and 1J respectively and G5 (Sham). Under the effect of analgesia, the brain of each group was collected and prepared for histopathological analysis by conventional optic microscopy. RESULTS: It was observed greater number of injured neurons in animals of group 4, however neuronal death also could be noticed in animals of group 5. Intraparenchymal hemorrhages were more frequent in animals of group 4 and the cytotoxic brain swelling and vascular congestion were more intense in this group CONCLUSION: The histopathological analysis of these findings allowed to observe typical cranial trauma alterations and these keep close relation with impact energy.

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Main Authors: Silva,Danilo dos Santos, Brito,José Nazareno Pearce de Oliveira, Ibiapina,Jerúsia Oliveira, Lima,Marcel Fernando Miranda Batista, Medeiros,Andréa Ribeiro Gonçalves de Vasconcelos, Queiroz,Bárbara Hamedy Carvalho e, Paiva,Aline Lariessy Campos, Guedes,Vanessa Olímpio de Melo
Format: Digital revista
Language:English
Published: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2012
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000400002
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spelling oai:scielo:S0102-865020120004000022012-04-24Closed head injury in rats: histopathological aspects in an experimental weight drop modelSilva,Danilo dos SantosBrito,José Nazareno Pearce de OliveiraIbiapina,Jerúsia OliveiraLima,Marcel Fernando Miranda BatistaMedeiros,Andréa Ribeiro Gonçalves de VasconcelosQueiroz,Bárbara Hamedy Carvalho ePaiva,Aline Lariessy CamposGuedes,Vanessa Olímpio de Melo Models Animal Brain Injuries Pathology Rats PURPOSE: To study histopathological findings due to a model of closed head injury by weight loss in rats. METHODS: A platform was used to induce closed cranial lesion controlled by weight loss with a known and predefined energy. 25 male Wistar rats (Rattus novergicus albinus) were divided in five equal groups which received different cranial impact energy levels: G1, G2, G3 and G4 with 0.234J, 0.5J, 0.762J and 1J respectively and G5 (Sham). Under the effect of analgesia, the brain of each group was collected and prepared for histopathological analysis by conventional optic microscopy. RESULTS: It was observed greater number of injured neurons in animals of group 4, however neuronal death also could be noticed in animals of group 5. Intraparenchymal hemorrhages were more frequent in animals of group 4 and the cytotoxic brain swelling and vascular congestion were more intense in this group CONCLUSION: The histopathological analysis of these findings allowed to observe typical cranial trauma alterations and these keep close relation with impact energy.info:eu-repo/semantics/openAccessSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira v.27 n.4 20122012-04-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000400002en10.1590/S0102-86502012000400002
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
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region America del Sur
libraryname SciELO
language English
format Digital
author Silva,Danilo dos Santos
Brito,José Nazareno Pearce de Oliveira
Ibiapina,Jerúsia Oliveira
Lima,Marcel Fernando Miranda Batista
Medeiros,Andréa Ribeiro Gonçalves de Vasconcelos
Queiroz,Bárbara Hamedy Carvalho e
Paiva,Aline Lariessy Campos
Guedes,Vanessa Olímpio de Melo
spellingShingle Silva,Danilo dos Santos
Brito,José Nazareno Pearce de Oliveira
Ibiapina,Jerúsia Oliveira
Lima,Marcel Fernando Miranda Batista
Medeiros,Andréa Ribeiro Gonçalves de Vasconcelos
Queiroz,Bárbara Hamedy Carvalho e
Paiva,Aline Lariessy Campos
Guedes,Vanessa Olímpio de Melo
Closed head injury in rats: histopathological aspects in an experimental weight drop model
author_facet Silva,Danilo dos Santos
Brito,José Nazareno Pearce de Oliveira
Ibiapina,Jerúsia Oliveira
Lima,Marcel Fernando Miranda Batista
Medeiros,Andréa Ribeiro Gonçalves de Vasconcelos
Queiroz,Bárbara Hamedy Carvalho e
Paiva,Aline Lariessy Campos
Guedes,Vanessa Olímpio de Melo
author_sort Silva,Danilo dos Santos
title Closed head injury in rats: histopathological aspects in an experimental weight drop model
title_short Closed head injury in rats: histopathological aspects in an experimental weight drop model
title_full Closed head injury in rats: histopathological aspects in an experimental weight drop model
title_fullStr Closed head injury in rats: histopathological aspects in an experimental weight drop model
title_full_unstemmed Closed head injury in rats: histopathological aspects in an experimental weight drop model
title_sort closed head injury in rats: histopathological aspects in an experimental weight drop model
description PURPOSE: To study histopathological findings due to a model of closed head injury by weight loss in rats. METHODS: A platform was used to induce closed cranial lesion controlled by weight loss with a known and predefined energy. 25 male Wistar rats (Rattus novergicus albinus) were divided in five equal groups which received different cranial impact energy levels: G1, G2, G3 and G4 with 0.234J, 0.5J, 0.762J and 1J respectively and G5 (Sham). Under the effect of analgesia, the brain of each group was collected and prepared for histopathological analysis by conventional optic microscopy. RESULTS: It was observed greater number of injured neurons in animals of group 4, however neuronal death also could be noticed in animals of group 5. Intraparenchymal hemorrhages were more frequent in animals of group 4 and the cytotoxic brain swelling and vascular congestion were more intense in this group CONCLUSION: The histopathological analysis of these findings allowed to observe typical cranial trauma alterations and these keep close relation with impact energy.
publisher Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publishDate 2012
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000400002
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