A herbal oil in water nano-emulsion prepared through an ecofriendly approach affects two tropical disease vectors

A herbal oil in water nano-emulsion prepared through an ecofriendly approach affects two tropical disease vectors

ABSTRACT Lippia alba (Mill.) N.E.Br. ex Britton & P. Wilson, Verbenaceae, is considered a great source of a bioactive volatile oil. Due to the wide range of known chemotypes, its chemical analysis is very important. Among the several activities of this volatile oil, a potential larvicidal action against Culicidae species is highlighted. However, the low water miscibility of volatile oils limits their application in aqueous media. Oil in water nano-emulsions are in the spotlight of novelty to solve this main problem. Thus, the aim of the present study was to obtain this nanostructured system with L. alba volatile oil (citral chemotype) and evaluate its larvicidal activity against Aedes aegypti and Culex quinquefasciatus larvae. The major compounds were geranial (30.02%) and neral (25.26%). Low mean droplet size (117.0 ± 1.0 nm) and low polydispersity index (0.231 ± 0.004) were observed and no major changes were observed after seven days of storage. LC50 values against C. quinquefasciatus and A. aegypti third-instar larvae were respectively 38.22 and 31.02 ppm, while LC90 values were, respectively, 59.42 and 47.19 ppm. The present study makes use of a low energy, solvent-free and ecofriendly method with reduced costs. Thus, this paper contributes significantly to phyto-nanobiotechnology of larvicidal agents, opening perspectives for the utilization of L. alba volatile oil in integrated practices of vector control.

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Main Authors: Ferreira,Ricardo M.A., Duarte,Jonatas L., Cruz,Rodrigo A.S., Oliveira,Anna E.M.F.M., Araújo,Raquel Silva, Carvalho,José C.T., Mourão,Rosa H.V., Souto,Raimundo N.P., Fernandes,Caio P.
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Farmacognosia 2019
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000600778
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spelling oai:scielo:S0102-695X20190006007782020-01-30A herbal oil in water nano-emulsion prepared through an ecofriendly approach affects two tropical disease vectorsFerreira,Ricardo M.A.Duarte,Jonatas L.Cruz,Rodrigo A.S.Oliveira,Anna E.M.F.M.Araújo,Raquel SilvaCarvalho,José C.T.Mourão,Rosa H.V.Souto,Raimundo N.P.Fernandes,Caio P. Colloidal system Droplet size distribution Miniemulsion Larvicide ABSTRACT Lippia alba (Mill.) N.E.Br. ex Britton & P. Wilson, Verbenaceae, is considered a great source of a bioactive volatile oil. Due to the wide range of known chemotypes, its chemical analysis is very important. Among the several activities of this volatile oil, a potential larvicidal action against Culicidae species is highlighted. However, the low water miscibility of volatile oils limits their application in aqueous media. Oil in water nano-emulsions are in the spotlight of novelty to solve this main problem. Thus, the aim of the present study was to obtain this nanostructured system with L. alba volatile oil (citral chemotype) and evaluate its larvicidal activity against Aedes aegypti and Culex quinquefasciatus larvae. The major compounds were geranial (30.02%) and neral (25.26%). Low mean droplet size (117.0 ± 1.0 nm) and low polydispersity index (0.231 ± 0.004) were observed and no major changes were observed after seven days of storage. LC50 values against C. quinquefasciatus and A. aegypti third-instar larvae were respectively 38.22 and 31.02 ppm, while LC90 values were, respectively, 59.42 and 47.19 ppm. The present study makes use of a low energy, solvent-free and ecofriendly method with reduced costs. Thus, this paper contributes significantly to phyto-nanobiotechnology of larvicidal agents, opening perspectives for the utilization of L. alba volatile oil in integrated practices of vector control.info:eu-repo/semantics/openAccessSociedade Brasileira de FarmacognosiaRevista Brasileira de Farmacognosia v.29 n.6 20192019-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000600778en10.1016/j.bjp.2019.05.003
institution SCIELO
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country Brasil
countrycode BR
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region America del Sur
libraryname SciELO
language English
format Digital
author Ferreira,Ricardo M.A.
Duarte,Jonatas L.
Cruz,Rodrigo A.S.
Oliveira,Anna E.M.F.M.
Araújo,Raquel Silva
Carvalho,José C.T.
Mourão,Rosa H.V.
Souto,Raimundo N.P.
Fernandes,Caio P.
spellingShingle Ferreira,Ricardo M.A.
Duarte,Jonatas L.
Cruz,Rodrigo A.S.
Oliveira,Anna E.M.F.M.
Araújo,Raquel Silva
Carvalho,José C.T.
Mourão,Rosa H.V.
Souto,Raimundo N.P.
Fernandes,Caio P.
A herbal oil in water nano-emulsion prepared through an ecofriendly approach affects two tropical disease vectors
author_facet Ferreira,Ricardo M.A.
Duarte,Jonatas L.
Cruz,Rodrigo A.S.
Oliveira,Anna E.M.F.M.
Araújo,Raquel Silva
Carvalho,José C.T.
Mourão,Rosa H.V.
Souto,Raimundo N.P.
Fernandes,Caio P.
author_sort Ferreira,Ricardo M.A.
title A herbal oil in water nano-emulsion prepared through an ecofriendly approach affects two tropical disease vectors
title_short A herbal oil in water nano-emulsion prepared through an ecofriendly approach affects two tropical disease vectors
title_full A herbal oil in water nano-emulsion prepared through an ecofriendly approach affects two tropical disease vectors
title_fullStr A herbal oil in water nano-emulsion prepared through an ecofriendly approach affects two tropical disease vectors
title_full_unstemmed A herbal oil in water nano-emulsion prepared through an ecofriendly approach affects two tropical disease vectors
title_sort herbal oil in water nano-emulsion prepared through an ecofriendly approach affects two tropical disease vectors
description ABSTRACT Lippia alba (Mill.) N.E.Br. ex Britton & P. Wilson, Verbenaceae, is considered a great source of a bioactive volatile oil. Due to the wide range of known chemotypes, its chemical analysis is very important. Among the several activities of this volatile oil, a potential larvicidal action against Culicidae species is highlighted. However, the low water miscibility of volatile oils limits their application in aqueous media. Oil in water nano-emulsions are in the spotlight of novelty to solve this main problem. Thus, the aim of the present study was to obtain this nanostructured system with L. alba volatile oil (citral chemotype) and evaluate its larvicidal activity against Aedes aegypti and Culex quinquefasciatus larvae. The major compounds were geranial (30.02%) and neral (25.26%). Low mean droplet size (117.0 ± 1.0 nm) and low polydispersity index (0.231 ± 0.004) were observed and no major changes were observed after seven days of storage. LC50 values against C. quinquefasciatus and A. aegypti third-instar larvae were respectively 38.22 and 31.02 ppm, while LC90 values were, respectively, 59.42 and 47.19 ppm. The present study makes use of a low energy, solvent-free and ecofriendly method with reduced costs. Thus, this paper contributes significantly to phyto-nanobiotechnology of larvicidal agents, opening perspectives for the utilization of L. alba volatile oil in integrated practices of vector control.
publisher Sociedade Brasileira de Farmacognosia
publishDate 2019
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000600778
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