Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon

Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon

Show other versions (1)

ABSTRACT Among 23 extracts of medicinal and edible plants tested, Mauritia flexuosa L.f., Arecaceae, showed significant antioxidant ability (DPPH and ORAC = 1062.9 and 645.9 ± 51.4 µg TE/mg extract, respectively), while Annona montana Macfad., Annonaceae, demonstrated the most promising anti-proliferative effect (IC50 for Hep-G2 and HT-29 = 2.7 and 9.0 µg/ml, respectively). However, combinatory antioxidant/anti-proliferative effect was only detected in Oenocarpus bataua Mart., Arecaceae (DPPH = 903.8 and ORAC = 1024 µg TE/mg extract; IC50 for Hep-G2 and HT-29 at 102.6 and 38.8 µg/ml, respectively) and Inga edulis Mart., Fabaceae (DPPH = 337.0 and ORAC = 795.7 µg TE/mg extract; IC50 for Hep-G2 and HT-29 at 36.3 and 57.9 µg/ml, respectively). Phenolic content was positively correlated with antioxidant potential, however not with anti-proliferative effect. None of these extracts possessed toxicity towards normal foetal lung cells, suggesting their possible use in development of novel plant-based agents with preventive and/or therapeutic action against oxidative stress-related diseases.

Saved in:
Bibliographic Details
Main Authors: Tauchen,Jan, Bortl,Ludvik, Huml,Lukas, Miksatkova,Petra, Doskocil,Ivo, Marsik,Petr, Villegas,Pablo Pedro Panduro, Flores,Ymber Bendezu, Damme,Patrick Van, Lojka,Bohdan, Havlik,Jaroslav, Lapcik,Oldrich, Kokoska,Ladislav
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Farmacognosia 2016
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000600728
Tags: Add Tag
No Tags, Be the first to tag this record!
id oai:scielo:S0102-695X2016000600728
record_format ojs
spelling oai:scielo:S0102-695X20160006007282016-12-05Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian AmazonTauchen,JanBortl,LudvikHuml,LukasMiksatkova,PetraDoskocil,IvoMarsik,PetrVillegas,Pablo Pedro PanduroFlores,Ymber BendezuDamme,Patrick VanLojka,BohdanHavlik,JaroslavLapcik,OldrichKokoska,Ladislav Antioxidant Anticarcinogenic Phenolic compounds Plant extracts ABSTRACT Among 23 extracts of medicinal and edible plants tested, Mauritia flexuosa L.f., Arecaceae, showed significant antioxidant ability (DPPH and ORAC = 1062.9 and 645.9 ± 51.4 µg TE/mg extract, respectively), while Annona montana Macfad., Annonaceae, demonstrated the most promising anti-proliferative effect (IC50 for Hep-G2 and HT-29 = 2.7 and 9.0 µg/ml, respectively). However, combinatory antioxidant/anti-proliferative effect was only detected in Oenocarpus bataua Mart., Arecaceae (DPPH = 903.8 and ORAC = 1024 µg TE/mg extract; IC50 for Hep-G2 and HT-29 at 102.6 and 38.8 µg/ml, respectively) and Inga edulis Mart., Fabaceae (DPPH = 337.0 and ORAC = 795.7 µg TE/mg extract; IC50 for Hep-G2 and HT-29 at 36.3 and 57.9 µg/ml, respectively). Phenolic content was positively correlated with antioxidant potential, however not with anti-proliferative effect. None of these extracts possessed toxicity towards normal foetal lung cells, suggesting their possible use in development of novel plant-based agents with preventive and/or therapeutic action against oxidative stress-related diseases.info:eu-repo/semantics/openAccessSociedade Brasileira de FarmacognosiaRevista Brasileira de Farmacognosia v.26 n.6 20162016-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000600728en10.1016/j.bjp.2016.03.016
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Tauchen,Jan
Bortl,Ludvik
Huml,Lukas
Miksatkova,Petra
Doskocil,Ivo
Marsik,Petr
Villegas,Pablo Pedro Panduro
Flores,Ymber Bendezu
Damme,Patrick Van
Lojka,Bohdan
Havlik,Jaroslav
Lapcik,Oldrich
Kokoska,Ladislav
spellingShingle Tauchen,Jan
Bortl,Ludvik
Huml,Lukas
Miksatkova,Petra
Doskocil,Ivo
Marsik,Petr
Villegas,Pablo Pedro Panduro
Flores,Ymber Bendezu
Damme,Patrick Van
Lojka,Bohdan
Havlik,Jaroslav
Lapcik,Oldrich
Kokoska,Ladislav
Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon
author_facet Tauchen,Jan
Bortl,Ludvik
Huml,Lukas
Miksatkova,Petra
Doskocil,Ivo
Marsik,Petr
Villegas,Pablo Pedro Panduro
Flores,Ymber Bendezu
Damme,Patrick Van
Lojka,Bohdan
Havlik,Jaroslav
Lapcik,Oldrich
Kokoska,Ladislav
author_sort Tauchen,Jan
title Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon
title_short Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon
title_full Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon
title_fullStr Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon
title_full_unstemmed Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon
title_sort phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the peruvian amazon
description ABSTRACT Among 23 extracts of medicinal and edible plants tested, Mauritia flexuosa L.f., Arecaceae, showed significant antioxidant ability (DPPH and ORAC = 1062.9 and 645.9 ± 51.4 µg TE/mg extract, respectively), while Annona montana Macfad., Annonaceae, demonstrated the most promising anti-proliferative effect (IC50 for Hep-G2 and HT-29 = 2.7 and 9.0 µg/ml, respectively). However, combinatory antioxidant/anti-proliferative effect was only detected in Oenocarpus bataua Mart., Arecaceae (DPPH = 903.8 and ORAC = 1024 µg TE/mg extract; IC50 for Hep-G2 and HT-29 at 102.6 and 38.8 µg/ml, respectively) and Inga edulis Mart., Fabaceae (DPPH = 337.0 and ORAC = 795.7 µg TE/mg extract; IC50 for Hep-G2 and HT-29 at 36.3 and 57.9 µg/ml, respectively). Phenolic content was positively correlated with antioxidant potential, however not with anti-proliferative effect. None of these extracts possessed toxicity towards normal foetal lung cells, suggesting their possible use in development of novel plant-based agents with preventive and/or therapeutic action against oxidative stress-related diseases.
publisher Sociedade Brasileira de Farmacognosia
publishDate 2016
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000600728
work_keys_str_mv AT tauchenjan phenoliccompositionantioxidantandantiproliferativeactivitiesofedibleandmedicinalplantsfromtheperuvianamazon
AT bortlludvik phenoliccompositionantioxidantandantiproliferativeactivitiesofedibleandmedicinalplantsfromtheperuvianamazon
AT humllukas phenoliccompositionantioxidantandantiproliferativeactivitiesofedibleandmedicinalplantsfromtheperuvianamazon
AT miksatkovapetra phenoliccompositionantioxidantandantiproliferativeactivitiesofedibleandmedicinalplantsfromtheperuvianamazon
AT doskocilivo phenoliccompositionantioxidantandantiproliferativeactivitiesofedibleandmedicinalplantsfromtheperuvianamazon
AT marsikpetr phenoliccompositionantioxidantandantiproliferativeactivitiesofedibleandmedicinalplantsfromtheperuvianamazon
AT villegaspablopedropanduro phenoliccompositionantioxidantandantiproliferativeactivitiesofedibleandmedicinalplantsfromtheperuvianamazon
AT floresymberbendezu phenoliccompositionantioxidantandantiproliferativeactivitiesofedibleandmedicinalplantsfromtheperuvianamazon
AT dammepatrickvan phenoliccompositionantioxidantandantiproliferativeactivitiesofedibleandmedicinalplantsfromtheperuvianamazon
AT lojkabohdan phenoliccompositionantioxidantandantiproliferativeactivitiesofedibleandmedicinalplantsfromtheperuvianamazon
AT havlikjaroslav phenoliccompositionantioxidantandantiproliferativeactivitiesofedibleandmedicinalplantsfromtheperuvianamazon
AT lapcikoldrich phenoliccompositionantioxidantandantiproliferativeactivitiesofedibleandmedicinalplantsfromtheperuvianamazon
AT kokoskaladislav phenoliccompositionantioxidantandantiproliferativeactivitiesofedibleandmedicinalplantsfromtheperuvianamazon
_version_ 1756399475873546240

Similar Items