Remission of long-term hepatic and renal disease induced by HCV after direct-acting antivirals therapy
Abstract In addition to liver disease, the hepatitis C virus (HCV) has been associated with autoimmune phenomena, such as mixed cryoglobulin and glomerulonephritis (GN). Until recently, both chronic hepatitis and HCV extra-hepatic manifestations were treated with peg-interferon plus ribavirin, however these drugs presented low efficacy and induced severe side effects. Nowadays, the HCV chronic hepatitis has been treated with direct acting antivirals (DAA), but studies on the DAA therapy for HCV-associated glomerulonephritis are scarce. Here, we describe two cases of HCV-associated glomerulonephritis that were treated with DAAs. In these two cases, previously experienced to peg-interferon plus ribavirin, the sofosbuvir plus simeprevir therapy was effective, without significant side effects, and interrupted the evolution of at least 20 years of both hepatic and renal diseases. These cases join the seven previously described cases that were treated with this DAAs association.
Main Authors: | Arruda,Raissa M, Batista,Andrea D, Filgueira,Norma A, Moura,Izolda F, Sette,Luis H, Lopes,Edmundo P |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Sociedade Brasileira de Nefrologia
2021
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002021000100117 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Selection dynamics of HCV genotype 3 resistance-associated substitutions under direct-acting antiviral therapy pressure
by: Rodrigues,João Paulo Vilela, et al.
Published: (2022) -
Causes of treatment failure for hepatitis C in the era of direct-acting antiviral therapy
by: Cabezas,Joaquín, et al.
Published: (2016) -
Treatment of Hepatitis C with Direct-Acting Antivirals does not Induce Significant Arrhythmias
by: Rezende,André Gustavo da Silva, et al.
Published: (2022) -
Genetic diversity of NS3 protease from Brazilian HCV isolates and possible implications for therapy with direct-acting antiviral drugs
by: Peres-da-Silva,Allan, et al.
Published: (2012) -
Patients' preferences for treatment with the new direct acting antiviral therapies for chronic hepatitis C virus infection
by: Simón,MA, et al.
Published: (2021)