Síntese de beta-N-acetilglicosaminídeos de arila modificados em C-6 como potenciais agentes antimicrobianos

We report herein the synthesis of aryl beta-N-acetylglucosaminides containing azido, amino and acetamido groups at C-6 as potential antimicrobial agents. It was expected that these compounds could interfere with the biosynthesis and/or biotransformation of N-acetylglucosamine in fungi and bacteria. None of the compounds showed antimicrobial activity against bacteria (Bacillus subtilis, Micrococcus luteus, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa), filamentous fungus (Aspergillus niger) and yeasts (Saccharomyces cerevisae, Candida albicans and Candida tropicallis), at the concentration of 1 mg/mL in agar diffusion assay.

Bibliographic Details

Main Authors:	Manfrini,Rozângela Magalhães, Souza Filho,José Dias de, Figueiredo,Rute Cunha, D'Angelis,Allison Fabiano, Prado,Maria Auxiliadora Fontes, Nunan,Elzíria de Aguiar, Martins,Gabriela Aires, Alves,Ricardo José
Format:	Digital revista
Language:	Portuguese
Published:	Sociedade Brasileira de Química 2008
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000200026
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