Plasmodium falciparum merozoite surface protein 3 as a vaccine candidate: a brief review
ABSTRACT Despite the many efforts of researchers around the world, there is currently no effective vaccine for malaria. Numerous studies have been developed to find vaccine antigens that are immunogenic and safe. Among antigen candidates, Plasmodium falciparum merozoite surface protein 3 (MSP3) has stood out in a number of these studies for its ability to induce a consistent and protective immune response, also being safe for use in humans. This review presents the main studies that explored MSP3 as a vaccine candidate over the last few decades. MSP3 formulations were tested in animals and humans and the most advanced candidate formulations are MSP3-LSP, a combination of MSP3 and LSP1, and GMZ2 (a vaccine based on the recombinant protein fusion GLURP and MSP3) which is currently being tested in phase II clinical studies. This brief review highlights the history and the main formulations of MSP3-based vaccines approaches against P. falciparum .
Main Authors: | Alves,Késsia Caroline Souza, Guimarães,Jander Matos, Almeida,Maria Edilene Martins de, Mariúba,Luís André Morais |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Instituto de Medicina Tropical de São Paulo
2022
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652022000100401 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Allelic Diversity at the Merozoite Surface Protein-1 (MSP-1) Locus in Natural Plasmodium falciparum Populations: a Brief Overview
by: Ferreira,Marcelo U, et al.
Published: (1998) -
Genetic diversity and differentiation in natural Plasmodium falciparum populations inferred by molecular typing of the merozoite surface proteins 1 and 2
by: Pereira,Fabrício J.T., et al.
Published: (2002) -
Naturally acquired antibodies to merozoite surface protein (MSP)-1(19) and cumulative exposure to Plasmodium falciparum and Plasmodium vivax in remote populations of the Amazon Basin of Brazil
by: Ladeia-Andrade,Simone, et al.
Published: (2007) -
Naturally acquired antibodies against the major merozoite surface coat protein (MSP-1) of Plasmodium falciparum acquired by residents in an endemic area of Colombia
by: Terrientes,Zillka I., et al.
Published: (1994) -
Efficience of human Plasmodium falciparum malaria vaccine candidates in Aotus lemurinus monkeys
by: Herrera,Socrates, et al.
Published: (1992)