Depression in Parkinson's disease: diagnosis and treatment
The prevalence of non-motor symptoms in Parkinson's disease (PD) is high. Depression varies from 20 to 50% of the PD patients, and is associated with increasing disability. The key characteristics of depression are anhedonia and low mood. The recommended scales for screening purposes are: HAM-D, BDI, HADS, MADRS and GDS. As for measurement of severity: HAM-D, MADRS, BDI and SDS. In cases with mild depression, non-pharmacological intervention is the treatment of choice. In moderate depression, antidepressants are required. The choice of an antidepressant should be based mainly on the comorbidities and unique features of the patient. Evidence for antidepressant effectiveness is seen mostly with amitriptyline and nortriptyline, but one should be cautious in elderly patients. Other antidepressants that can be prescribed are: citalopram, escitalopram, sertraline, bupropion, trazodone, venlafaxine, mirtazapine and duloxetin. The dopaminergic agonist pramipexole is a treatment option.
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Academia Brasileira de Neurologia - ABNEURO
2012
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oai:scielo:S0004-282X20120008000112012-08-14Depression in Parkinson's disease: diagnosis and treatmentCosta,Flavio Henrique de RezendeRosso,Ana Lucia ZumaMaultasch,HenrykNicaretta,Denise HackVincent,Maurice Borges depression Parkinson disease non-motor symptoms The prevalence of non-motor symptoms in Parkinson's disease (PD) is high. Depression varies from 20 to 50% of the PD patients, and is associated with increasing disability. The key characteristics of depression are anhedonia and low mood. The recommended scales for screening purposes are: HAM-D, BDI, HADS, MADRS and GDS. As for measurement of severity: HAM-D, MADRS, BDI and SDS. In cases with mild depression, non-pharmacological intervention is the treatment of choice. In moderate depression, antidepressants are required. The choice of an antidepressant should be based mainly on the comorbidities and unique features of the patient. Evidence for antidepressant effectiveness is seen mostly with amitriptyline and nortriptyline, but one should be cautious in elderly patients. Other antidepressants that can be prescribed are: citalopram, escitalopram, sertraline, bupropion, trazodone, venlafaxine, mirtazapine and duloxetin. The dopaminergic agonist pramipexole is a treatment option.info:eu-repo/semantics/openAccessAcademia Brasileira de Neurologia - ABNEUROArquivos de Neuro-Psiquiatria v.70 n.8 20122012-08-01info:eu-repo/semantics/othertext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000800011en10.1590/S0004-282X2012000800011 |
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Costa,Flavio Henrique de Rezende Rosso,Ana Lucia Zuma Maultasch,Henryk Nicaretta,Denise Hack Vincent,Maurice Borges |
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Costa,Flavio Henrique de Rezende Rosso,Ana Lucia Zuma Maultasch,Henryk Nicaretta,Denise Hack Vincent,Maurice Borges Depression in Parkinson's disease: diagnosis and treatment |
author_facet |
Costa,Flavio Henrique de Rezende Rosso,Ana Lucia Zuma Maultasch,Henryk Nicaretta,Denise Hack Vincent,Maurice Borges |
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Costa,Flavio Henrique de Rezende |
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Depression in Parkinson's disease: diagnosis and treatment |
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Depression in Parkinson's disease: diagnosis and treatment |
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Depression in Parkinson's disease: diagnosis and treatment |
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Depression in Parkinson's disease: diagnosis and treatment |
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Depression in Parkinson's disease: diagnosis and treatment |
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depression in parkinson's disease: diagnosis and treatment |
description |
The prevalence of non-motor symptoms in Parkinson's disease (PD) is high. Depression varies from 20 to 50% of the PD patients, and is associated with increasing disability. The key characteristics of depression are anhedonia and low mood. The recommended scales for screening purposes are: HAM-D, BDI, HADS, MADRS and GDS. As for measurement of severity: HAM-D, MADRS, BDI and SDS. In cases with mild depression, non-pharmacological intervention is the treatment of choice. In moderate depression, antidepressants are required. The choice of an antidepressant should be based mainly on the comorbidities and unique features of the patient. Evidence for antidepressant effectiveness is seen mostly with amitriptyline and nortriptyline, but one should be cautious in elderly patients. Other antidepressants that can be prescribed are: citalopram, escitalopram, sertraline, bupropion, trazodone, venlafaxine, mirtazapine and duloxetin. The dopaminergic agonist pramipexole is a treatment option. |
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Academia Brasileira de Neurologia - ABNEURO |
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2012 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000800011 |
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