Lack of association between VNTR polymorphism of dopamine transporter gene (SLC6A3) and schizophrenia in a Brazilian sample
A role of dopaminergic dysfunction has been postulated in the aetiology of schizophrenia. We hypothesized that variations in the dopamine transporter gene (SLC6A3) may be associated with schizophrenia. We conducted case-control and family based analysis on the polymorphic SLC6A3 variable number tandem repeat (VNTR) in a sample of 220 schizophrenic patients, 226 gender and ethnic matched controls, and 49 additional case-parent trios. No differences were found in allelic or genotypic distributions between cases and controls and no significant transmission distortions from heterozygous parents to schizophrenic offspring were detected. Thus, our results do not support an association of the SLC6A3 VNTR with schizophrenia in our sample.
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Academia Brasileira de Neurologia - ABNEURO
2004
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oai:scielo:S0004-282X20040006000082006-04-25Lack of association between VNTR polymorphism of dopamine transporter gene (SLC6A3) and schizophrenia in a Brazilian sampleCordeiro,QuirinoTalkowski,MichaelWood,JoelIkenaga,ElizaVallada,Homero DAT1 SLC6A3 schizophrenia genetic polymorphism genetic association trios A role of dopaminergic dysfunction has been postulated in the aetiology of schizophrenia. We hypothesized that variations in the dopamine transporter gene (SLC6A3) may be associated with schizophrenia. We conducted case-control and family based analysis on the polymorphic SLC6A3 variable number tandem repeat (VNTR) in a sample of 220 schizophrenic patients, 226 gender and ethnic matched controls, and 49 additional case-parent trios. No differences were found in allelic or genotypic distributions between cases and controls and no significant transmission distortions from heterozygous parents to schizophrenic offspring were detected. Thus, our results do not support an association of the SLC6A3 VNTR with schizophrenia in our sample.info:eu-repo/semantics/openAccessAcademia Brasileira de Neurologia - ABNEUROArquivos de Neuro-Psiquiatria v.62 n.4 20042004-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2004000600008en10.1590/S0004-282X2004000600008 |
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Cordeiro,Quirino Talkowski,Michael Wood,Joel Ikenaga,Eliza Vallada,Homero |
| spellingShingle |
Cordeiro,Quirino Talkowski,Michael Wood,Joel Ikenaga,Eliza Vallada,Homero Lack of association between VNTR polymorphism of dopamine transporter gene (SLC6A3) and schizophrenia in a Brazilian sample |
| author_facet |
Cordeiro,Quirino Talkowski,Michael Wood,Joel Ikenaga,Eliza Vallada,Homero |
| author_sort |
Cordeiro,Quirino |
| title |
Lack of association between VNTR polymorphism of dopamine transporter gene (SLC6A3) and schizophrenia in a Brazilian sample |
| title_short |
Lack of association between VNTR polymorphism of dopamine transporter gene (SLC6A3) and schizophrenia in a Brazilian sample |
| title_full |
Lack of association between VNTR polymorphism of dopamine transporter gene (SLC6A3) and schizophrenia in a Brazilian sample |
| title_fullStr |
Lack of association between VNTR polymorphism of dopamine transporter gene (SLC6A3) and schizophrenia in a Brazilian sample |
| title_full_unstemmed |
Lack of association between VNTR polymorphism of dopamine transporter gene (SLC6A3) and schizophrenia in a Brazilian sample |
| title_sort |
lack of association between vntr polymorphism of dopamine transporter gene (slc6a3) and schizophrenia in a brazilian sample |
| description |
A role of dopaminergic dysfunction has been postulated in the aetiology of schizophrenia. We hypothesized that variations in the dopamine transporter gene (SLC6A3) may be associated with schizophrenia. We conducted case-control and family based analysis on the polymorphic SLC6A3 variable number tandem repeat (VNTR) in a sample of 220 schizophrenic patients, 226 gender and ethnic matched controls, and 49 additional case-parent trios. No differences were found in allelic or genotypic distributions between cases and controls and no significant transmission distortions from heterozygous parents to schizophrenic offspring were detected. Thus, our results do not support an association of the SLC6A3 VNTR with schizophrenia in our sample. |
| publisher |
Academia Brasileira de Neurologia - ABNEURO |
| publishDate |
2004 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2004000600008 |
| work_keys_str_mv |
AT cordeiroquirino lackofassociationbetweenvntrpolymorphismofdopaminetransportergeneslc6a3andschizophreniainabraziliansample AT talkowskimichael lackofassociationbetweenvntrpolymorphismofdopaminetransportergeneslc6a3andschizophreniainabraziliansample AT woodjoel lackofassociationbetweenvntrpolymorphismofdopaminetransportergeneslc6a3andschizophreniainabraziliansample AT ikenagaeliza lackofassociationbetweenvntrpolymorphismofdopaminetransportergeneslc6a3andschizophreniainabraziliansample AT valladahomero lackofassociationbetweenvntrpolymorphismofdopaminetransportergeneslc6a3andschizophreniainabraziliansample |
| _version_ |
1756374285069320192 |