Evaluation of the anti-osteoporotic effect of Ginkgo biloba L. in Wistar rats with glucocorticoid-induced-osteoporosis by bone densitometry using dual-energy x-ray absorptiometry (DEXA) and mechanical testing

Evaluation of the anti-osteoporotic effect of Ginkgo biloba L. in Wistar rats with glucocorticoid-induced-osteoporosis by bone densitometry using dual-energy x-ray absorptiometry (DEXA) and mechanical testing

ABSTRACT Evaluate the effect of the extract of Ginkgo biloba in the bone alkaline phosphatase, bone mineral density, in the mechanical properties of the tibia in rats with glucocorticoid-induced-osteoporosis. After osteoporosis induction, the rats were divided into five groups: Osteoporosis; EGb1 (28 mg/Kg); EGb2 (56 mg/Kg); alendronate (0.2 mg/animal) and control. The animals were treated during 20 and 30 days. The control group was compared with the osteoporosis’s (Student’s t-test), while the other were analyzed by ANOVA test followed by Tukey/Dunnett’T3 (p<0.05). In the osteoporosis group the bone alkaline phosphatase, bone mineral density, the bone stiffness, the maximum load and the resilience were reduced. The bone alkaline phosphatase values increased in the EGb1 and EGb2 groups (30 days). In addition, in the EGb2 and alendronate groups (20 and 30 days) the bone mineral density increased. The extract of Ginkgo biloba restored bone alkaline phosphatase and bone mineral density using dual-energy x-ray absorptiometry.

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Main Authors: LUCINDA,LEDA M.F., AARESTRUP,BEATRIZ J.V., REBOREDO,MAYCON M., PAINS,THAIS D.A., CHAVES,RAPHAEL Z., REIS,JOÃO E.P., LOUZADA,MÁRIO J.Q., GUERRA,MARTHA O.
Format: Digital revista
Language:English
Published: Academia Brasileira de Ciências 2017
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000602833
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spelling oai:scielo:S0001-376520170006028332020-07-24Evaluation of the anti-osteoporotic effect of Ginkgo biloba L. in Wistar rats with glucocorticoid-induced-osteoporosis by bone densitometry using dual-energy x-ray absorptiometry (DEXA) and mechanical testingLUCINDA,LEDA M.F.AARESTRUP,BEATRIZ J.V.REBOREDO,MAYCON M.PAINS,THAIS D.A.CHAVES,RAPHAEL Z.REIS,JOÃO E.P.LOUZADA,MÁRIO J.Q.GUERRA,MARTHA O. bone density DEXA scan Ginkgo biloba osteoporosis ABSTRACT Evaluate the effect of the extract of Ginkgo biloba in the bone alkaline phosphatase, bone mineral density, in the mechanical properties of the tibia in rats with glucocorticoid-induced-osteoporosis. After osteoporosis induction, the rats were divided into five groups: Osteoporosis; EGb1 (28 mg/Kg); EGb2 (56 mg/Kg); alendronate (0.2 mg/animal) and control. The animals were treated during 20 and 30 days. The control group was compared with the osteoporosis’s (Student’s t-test), while the other were analyzed by ANOVA test followed by Tukey/Dunnett’T3 (p<0.05). In the osteoporosis group the bone alkaline phosphatase, bone mineral density, the bone stiffness, the maximum load and the resilience were reduced. The bone alkaline phosphatase values increased in the EGb1 and EGb2 groups (30 days). In addition, in the EGb2 and alendronate groups (20 and 30 days) the bone mineral density increased. The extract of Ginkgo biloba restored bone alkaline phosphatase and bone mineral density using dual-energy x-ray absorptiometry.info:eu-repo/semantics/openAccessAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências v.89 n.4 20172017-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000602833en10.1590/0001-3765201720160479
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countrycode BR
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language English
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author LUCINDA,LEDA M.F.
AARESTRUP,BEATRIZ J.V.
REBOREDO,MAYCON M.
PAINS,THAIS D.A.
CHAVES,RAPHAEL Z.
REIS,JOÃO E.P.
LOUZADA,MÁRIO J.Q.
GUERRA,MARTHA O.
spellingShingle LUCINDA,LEDA M.F.
AARESTRUP,BEATRIZ J.V.
REBOREDO,MAYCON M.
PAINS,THAIS D.A.
CHAVES,RAPHAEL Z.
REIS,JOÃO E.P.
LOUZADA,MÁRIO J.Q.
GUERRA,MARTHA O.
Evaluation of the anti-osteoporotic effect of Ginkgo biloba L. in Wistar rats with glucocorticoid-induced-osteoporosis by bone densitometry using dual-energy x-ray absorptiometry (DEXA) and mechanical testing
author_facet LUCINDA,LEDA M.F.
AARESTRUP,BEATRIZ J.V.
REBOREDO,MAYCON M.
PAINS,THAIS D.A.
CHAVES,RAPHAEL Z.
REIS,JOÃO E.P.
LOUZADA,MÁRIO J.Q.
GUERRA,MARTHA O.
author_sort LUCINDA,LEDA M.F.
title Evaluation of the anti-osteoporotic effect of Ginkgo biloba L. in Wistar rats with glucocorticoid-induced-osteoporosis by bone densitometry using dual-energy x-ray absorptiometry (DEXA) and mechanical testing
title_short Evaluation of the anti-osteoporotic effect of Ginkgo biloba L. in Wistar rats with glucocorticoid-induced-osteoporosis by bone densitometry using dual-energy x-ray absorptiometry (DEXA) and mechanical testing
title_full Evaluation of the anti-osteoporotic effect of Ginkgo biloba L. in Wistar rats with glucocorticoid-induced-osteoporosis by bone densitometry using dual-energy x-ray absorptiometry (DEXA) and mechanical testing
title_fullStr Evaluation of the anti-osteoporotic effect of Ginkgo biloba L. in Wistar rats with glucocorticoid-induced-osteoporosis by bone densitometry using dual-energy x-ray absorptiometry (DEXA) and mechanical testing
title_full_unstemmed Evaluation of the anti-osteoporotic effect of Ginkgo biloba L. in Wistar rats with glucocorticoid-induced-osteoporosis by bone densitometry using dual-energy x-ray absorptiometry (DEXA) and mechanical testing
title_sort evaluation of the anti-osteoporotic effect of ginkgo biloba l. in wistar rats with glucocorticoid-induced-osteoporosis by bone densitometry using dual-energy x-ray absorptiometry (dexa) and mechanical testing
description ABSTRACT Evaluate the effect of the extract of Ginkgo biloba in the bone alkaline phosphatase, bone mineral density, in the mechanical properties of the tibia in rats with glucocorticoid-induced-osteoporosis. After osteoporosis induction, the rats were divided into five groups: Osteoporosis; EGb1 (28 mg/Kg); EGb2 (56 mg/Kg); alendronate (0.2 mg/animal) and control. The animals were treated during 20 and 30 days. The control group was compared with the osteoporosis’s (Student’s t-test), while the other were analyzed by ANOVA test followed by Tukey/Dunnett’T3 (p<0.05). In the osteoporosis group the bone alkaline phosphatase, bone mineral density, the bone stiffness, the maximum load and the resilience were reduced. The bone alkaline phosphatase values increased in the EGb1 and EGb2 groups (30 days). In addition, in the EGb2 and alendronate groups (20 and 30 days) the bone mineral density increased. The extract of Ginkgo biloba restored bone alkaline phosphatase and bone mineral density using dual-energy x-ray absorptiometry.
publisher Academia Brasileira de Ciências
publishDate 2017
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000602833
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