Efficacy of a vectorized vaccine for the control of Newcastle Disease applied in chicks in the hatchery

Efficacy of a vectorized vaccine for the control of Newcastle Disease applied in chicks in the hatchery

The present study evaluated the efficacy of a vectorized vaccine against Newcastle disease virus (vENC) applied in the hatchery. Two hundred one-day-old chicks were distributed in four experimental vaccination groups against vENC: T1: Live attenuated vaccine + inactivated vaccine, T2: Live attenuated vaccine, T3: Live attenuated vaccine + vectorized vaccine, T4: Unvaccinated control group. All chicks were also vaccinated against infectious bronchitis, Marek and Gumboro viruses at day 1. The birds were challenged on the day 26 with a highly pathogenic field pathogenic strain. Mortality, post-challenge clinical signs, necropsy lesions and antibody response against vENC were evaluated. Chicks vaccinated with the vENC vectorized vaccine had a lower mortality (2%) compared to birds vaccinated with live attenuated strains (12.5% ​​for T1 and 18.4% for T2 respectively; p<0.05). Likewise, a lower percentage of post-challenge clinical manifestations (p<0.05) and of lesions in organs at necropsy. The results indicate a better protective effect using the vectorized vaccine and its potential use for the control of vENC under field conditions.  

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Main Authors: Sialer G., Mercedes, Icochea D’A., Eliana, González Z., Armando E.
Format: Digital revista
Language:spa
Published: Universidad Nacional Mayor de San Marcos, Facultad de Medicina Veterinaria 2020
Online Access:https://revistasinvestigacion.unmsm.edu.pe/index.php/veterinaria/article/view/17835
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spelling oai:ojs.csi.unmsm:article-178352020-06-23T19:46:03Z Efficacy of a vectorized vaccine for the control of Newcastle Disease applied in chicks in the hatchery Eficacia de una vacuna vectorizada para el control de la enfermedad de Newcastle aplicada en pollitos BB en planta de incubación Sialer G., Mercedes Icochea D’A., Eliana González Z., Armando E. Newcastle disease vectorized vaccine velogenic strain enfermedad de Newcastle vacuna vectorizada cepa velogénica The present study evaluated the efficacy of a vectorized vaccine against Newcastle disease virus (vENC) applied in the hatchery. Two hundred one-day-old chicks were distributed in four experimental vaccination groups against vENC: T1: Live attenuated vaccine + inactivated vaccine, T2: Live attenuated vaccine, T3: Live attenuated vaccine + vectorized vaccine, T4: Unvaccinated control group. All chicks were also vaccinated against infectious bronchitis, Marek and Gumboro viruses at day 1. The birds were challenged on the day 26 with a highly pathogenic field pathogenic strain. Mortality, post-challenge clinical signs, necropsy lesions and antibody response against vENC were evaluated. Chicks vaccinated with the vENC vectorized vaccine had a lower mortality (2%) compared to birds vaccinated with live attenuated strains (12.5% ​​for T1 and 18.4% for T2 respectively; p<0.05). Likewise, a lower percentage of post-challenge clinical manifestations (p<0.05) and of lesions in organs at necropsy. The results indicate a better protective effect using the vectorized vaccine and its potential use for the control of vENC under field conditions.   El presente estudio evaluó la eficacia de una vacuna vectorizada contra el virus de la enfermedad de Newcastle (vENC) aplicada en planta de incubación. Doscientos pollitos BB fueron distribuidos en cuatro grupos experimentales de vacunación contra vENC: T1: Vacuna viva atenuada + vacuna inactivada, T2: Vacuna viva atenuada, T3: Vacuna viva atenuada + vacuna vectorizada, T4: Grupo control no vacunado. Todas las aves fueron, además, vacunadas contra el virus de Bronquitis infecciosa, Marek y Gumboro el día 1. Las aves fueron desafiadas el día 26 con una cepa velogénica de campo altamente patógena. Se evaluó la mortalidad, signos clínicos pos-desafío, lesiones en la necropsia y respuesta de anticuerpos contra vENC. Las aves vacunadas con la vacuna vectorizada de vENC presentaron una menor mortalidad (2%) en comparación a las aves vacunadas con cepas vivas atenuadas (12.5% para T1 y 18.4% para T2, respectivamente; p<0.05). Asimismo, menor porcentaje de manifestaciones clínicas pos-desafío (p<0.05) y de lesiones en órganos a la necropsia. Los resultados indican un mejor efecto protector mediante el uso de la vacuna vectorizada y su uso potencial para el control de vENC en condiciones de campo. Universidad Nacional Mayor de San Marcos, Facultad de Medicina Veterinaria 2020-06-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article application/pdf https://revistasinvestigacion.unmsm.edu.pe/index.php/veterinaria/article/view/17835 10.15381/rivep.v31i2.17835 Revista de Investigaciones Veterinarias del Perú; Vol. 31 No. 2 (2020); e17835 Revista de Investigaciones Veterinarias del Perú; Vol. 31 Núm. 2 (2020); e17835 1682-3419 1609-9117 spa https://revistasinvestigacion.unmsm.edu.pe/index.php/veterinaria/article/view/17835/15110 Derechos de autor 2020 Mercedes Sialer G., Eliana Icochea D’A., Armando E. González Z. https://creativecommons.org/licenses/by-nc-sa/4.0
institution UNMSM
collection OJS
country Perú
countrycode PE
component Revista
access En linea
databasecode rev-rivep
tag revista
region America del Sur
libraryname Biblioteca de la Facultad de Medicina Veterinaria
language spa
format Digital
author Sialer G., Mercedes
Icochea D’A., Eliana
González Z., Armando E.
spellingShingle Sialer G., Mercedes
Icochea D’A., Eliana
González Z., Armando E.
Efficacy of a vectorized vaccine for the control of Newcastle Disease applied in chicks in the hatchery
author_facet Sialer G., Mercedes
Icochea D’A., Eliana
González Z., Armando E.
author_sort Sialer G., Mercedes
title Efficacy of a vectorized vaccine for the control of Newcastle Disease applied in chicks in the hatchery
title_short Efficacy of a vectorized vaccine for the control of Newcastle Disease applied in chicks in the hatchery
title_full Efficacy of a vectorized vaccine for the control of Newcastle Disease applied in chicks in the hatchery
title_fullStr Efficacy of a vectorized vaccine for the control of Newcastle Disease applied in chicks in the hatchery
title_full_unstemmed Efficacy of a vectorized vaccine for the control of Newcastle Disease applied in chicks in the hatchery
title_sort efficacy of a vectorized vaccine for the control of newcastle disease applied in chicks in the hatchery
description The present study evaluated the efficacy of a vectorized vaccine against Newcastle disease virus (vENC) applied in the hatchery. Two hundred one-day-old chicks were distributed in four experimental vaccination groups against vENC: T1: Live attenuated vaccine + inactivated vaccine, T2: Live attenuated vaccine, T3: Live attenuated vaccine + vectorized vaccine, T4: Unvaccinated control group. All chicks were also vaccinated against infectious bronchitis, Marek and Gumboro viruses at day 1. The birds were challenged on the day 26 with a highly pathogenic field pathogenic strain. Mortality, post-challenge clinical signs, necropsy lesions and antibody response against vENC were evaluated. Chicks vaccinated with the vENC vectorized vaccine had a lower mortality (2%) compared to birds vaccinated with live attenuated strains (12.5% ​​for T1 and 18.4% for T2 respectively; p<0.05). Likewise, a lower percentage of post-challenge clinical manifestations (p<0.05) and of lesions in organs at necropsy. The results indicate a better protective effect using the vectorized vaccine and its potential use for the control of vENC under field conditions.  
publisher Universidad Nacional Mayor de San Marcos, Facultad de Medicina Veterinaria
publishDate 2020
url https://revistasinvestigacion.unmsm.edu.pe/index.php/veterinaria/article/view/17835
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