Sleep-disordered breathing and oxidative stress in preclinical chronic mountain sickness (excessive erythrocytosis)
Abstract. Chronic mountain sickness (CMS) is considered to be a loss of ventilatory acclimatization to high altitude (>2500 m) resulting in marked arterial hypoxemia and polycythemia. This case-control study explores the possibility that sleep-disordered breathing (SBD) and associated oxidative stress contribute to the etiology of CMS. Nocturnal respiratory and SaO2 patterns were measured using standard polysomnography techniques and compared between male high-altitude residents (aged 18–25) with preclinical CMS ([excessive erythrocytosis (EE)], n=20) and controls (n=19). Measures of oxidative stress and antioxidant status included isoprostanes (8-iso-PGF2 alpha), superoxide dismutase and ascorbic acid. EE cases had a greater apnea-hypopnea index, a higher frequency of apneas (central and obstructive) and hypopneas during REM sleep, and lower nocturnal SaO2 compared to controls. 8-iso-PGF2alpha was greater in EE than controls, negatively associated with nocturnal SaO2, and positively associated with hemoglobin concentration. Mild sleep-disordered breathing and oxidative stress are evident in preclinical CMS, suggesting that the resolution of nocturnal hypoxemia or antioxidant treatment may prevent disease progression.
Main Authors: | , , , , , , , , , |
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Format: | Article biblioteca |
Language: | English |
Published: |
Respiratory Physiology & Neurobiology
2013-01-22
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Subjects: | ALTURA, ESTRÉS OXIDATIVO, POLICITEMIA, |
Online Access: | http://repositorio.umsa.bo/xmlui/handle/123456789/8022 |
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Summary: | Abstract.
Chronic mountain sickness (CMS) is considered to be a loss of ventilatory acclimatization to high
altitude (>2500 m) resulting in marked arterial hypoxemia and polycythemia. This case-control
study explores the possibility that sleep-disordered breathing (SBD) and associated oxidative
stress contribute to the etiology of CMS. Nocturnal respiratory and SaO2 patterns were measured
using standard polysomnography techniques and compared between male high-altitude residents
(aged 18–25) with preclinical CMS ([excessive erythrocytosis (EE)], n=20) and controls (n=19).
Measures of oxidative stress and antioxidant status included isoprostanes (8-iso-PGF2 alpha),
superoxide dismutase and ascorbic acid. EE cases had a greater apnea-hypopnea index, a higher
frequency of apneas (central and obstructive) and hypopneas during REM sleep, and lower
nocturnal SaO2 compared to controls. 8-iso-PGF2alpha was greater in EE than controls, negatively
associated with nocturnal SaO2, and positively associated with hemoglobin concentration. Mild
sleep-disordered breathing and oxidative stress are evident in preclinical CMS, suggesting that the
resolution of nocturnal hypoxemia or antioxidant treatment may prevent disease progression. |
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