Pulmonary gas exchange in Andean nativos with excessive polycythemia - efecct of hemodilution
Pulmonary gas exchange in andean natives (n =8) with excessive high-altitude (3,600-4,200 m) polycythemia (hematocrit 65.1 +- 6.6%) and hipoxemia (arterial PO2 45.6+-5.6 Torr) in the absence of pulmonary or cardiovascular disease was investigated both before and after isovolemic hemodilution by use of the inert gas elimination technique. The investigations were carried out in La Paz, Bolivia (3,650 m, 500 mmHg barometric poressure). Before hemodilution, a low ventilation-perfusion (VA/Q) mode (VA/Q <0.1 without true shunt accounted for 11.6+-5.5% of the total blood flow and was mainly responsible for the hypoxemia. The hypoventilation with a low mixed venous PO2 value may have contributed to the observed hypoxemia in the absence of an impairment in alveolar capillary diffusion. After hemodilution, cardiac output and ventilation increased from 5.5 +- 1.2 to 6.9 +-1.2 1/min and from 8.5 +- 1.4 to 9.6 +- 1.3 1/min, respectively, although arterial and venous PO2 remained constant. VA/Q mismatching fell slightly but significantly. The hypoxemia observed in subjects suffering from high-altitude excessive polycythemia was attributed to an increased in blood flow perfusing poorly ventilated areas, but without true intraor extrapulmonary shunt. Hypoventilation as well as a low mixed venous PO2 value may also have contributed to the observed hypoxemia.
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Language: | English |
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J. Appl. Physiol.
1988
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Subjects: | MAL CRÓNICO DE MONTAÑA, POLICITEMIA SECUNDARIA, RELACIÓN VENTILACIÓN-PERFUSIÓN, ELIMINACIÓN DE GAS INERTE, |
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oai:localhost:8080:123456789-105532020-09-10T16:27:09Z Pulmonary gas exchange in Andean nativos with excessive polycythemia - efecct of hemodilution Manier, Gérard Guenard, Hervé Castaing, Yves Varene, Nicole Vargas, Enrique MAL CRÓNICO DE MONTAÑA POLICITEMIA SECUNDARIA RELACIÓN VENTILACIÓN-PERFUSIÓN ELIMINACIÓN DE GAS INERTE Pulmonary gas exchange in andean natives (n =8) with excessive high-altitude (3,600-4,200 m) polycythemia (hematocrit 65.1 +- 6.6%) and hipoxemia (arterial PO2 45.6+-5.6 Torr) in the absence of pulmonary or cardiovascular disease was investigated both before and after isovolemic hemodilution by use of the inert gas elimination technique. The investigations were carried out in La Paz, Bolivia (3,650 m, 500 mmHg barometric poressure). Before hemodilution, a low ventilation-perfusion (VA/Q) mode (VA/Q <0.1 without true shunt accounted for 11.6+-5.5% of the total blood flow and was mainly responsible for the hypoxemia. The hypoventilation with a low mixed venous PO2 value may have contributed to the observed hypoxemia in the absence of an impairment in alveolar capillary diffusion. After hemodilution, cardiac output and ventilation increased from 5.5 +- 1.2 to 6.9 +-1.2 1/min and from 8.5 +- 1.4 to 9.6 +- 1.3 1/min, respectively, although arterial and venous PO2 remained constant. VA/Q mismatching fell slightly but significantly. The hypoxemia observed in subjects suffering from high-altitude excessive polycythemia was attributed to an increased in blood flow perfusing poorly ventilated areas, but without true intraor extrapulmonary shunt. Hypoventilation as well as a low mixed venous PO2 value may also have contributed to the observed hypoxemia. 2017-05-22T15:24:14Z 2017-05-22T15:24:14Z 1988 Article http://repositorio.umsa.bo/xmlui/handle/123456789/10553 en application/pdf J. Appl. Physiol. |
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MAL CRÓNICO DE MONTAÑA POLICITEMIA SECUNDARIA RELACIÓN VENTILACIÓN-PERFUSIÓN ELIMINACIÓN DE GAS INERTE MAL CRÓNICO DE MONTAÑA POLICITEMIA SECUNDARIA RELACIÓN VENTILACIÓN-PERFUSIÓN ELIMINACIÓN DE GAS INERTE |
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MAL CRÓNICO DE MONTAÑA POLICITEMIA SECUNDARIA RELACIÓN VENTILACIÓN-PERFUSIÓN ELIMINACIÓN DE GAS INERTE MAL CRÓNICO DE MONTAÑA POLICITEMIA SECUNDARIA RELACIÓN VENTILACIÓN-PERFUSIÓN ELIMINACIÓN DE GAS INERTE Manier, Gérard Guenard, Hervé Castaing, Yves Varene, Nicole Vargas, Enrique Pulmonary gas exchange in Andean nativos with excessive polycythemia - efecct of hemodilution |
description |
Pulmonary gas exchange in andean natives (n =8) with excessive high-altitude (3,600-4,200 m) polycythemia (hematocrit 65.1 +- 6.6%) and hipoxemia (arterial PO2 45.6+-5.6 Torr) in the absence of pulmonary or cardiovascular disease was investigated both before and after isovolemic hemodilution by use of the inert gas elimination technique. The investigations were carried out in La Paz, Bolivia (3,650 m, 500 mmHg barometric poressure). Before hemodilution, a low ventilation-perfusion (VA/Q) mode (VA/Q <0.1 without true shunt accounted for 11.6+-5.5% of the total blood flow and was mainly responsible for the hypoxemia. The hypoventilation with a low mixed venous PO2 value may have contributed to the observed hypoxemia in the absence of an impairment in alveolar capillary diffusion. After hemodilution, cardiac output and ventilation increased from 5.5 +- 1.2 to 6.9 +-1.2 1/min and from 8.5 +- 1.4 to 9.6 +- 1.3 1/min, respectively, although arterial and venous PO2 remained constant. VA/Q mismatching fell slightly but significantly. The hypoxemia observed in subjects suffering from high-altitude excessive polycythemia was attributed to an increased in blood flow perfusing poorly ventilated areas, but without true intraor extrapulmonary shunt. Hypoventilation as well as a low mixed venous PO2 value may also have contributed to the observed hypoxemia. |
format |
Article |
topic_facet |
MAL CRÓNICO DE MONTAÑA POLICITEMIA SECUNDARIA RELACIÓN VENTILACIÓN-PERFUSIÓN ELIMINACIÓN DE GAS INERTE |
author |
Manier, Gérard Guenard, Hervé Castaing, Yves Varene, Nicole Vargas, Enrique |
author_facet |
Manier, Gérard Guenard, Hervé Castaing, Yves Varene, Nicole Vargas, Enrique |
author_sort |
Manier, Gérard |
title |
Pulmonary gas exchange in Andean nativos with excessive polycythemia - efecct of hemodilution |
title_short |
Pulmonary gas exchange in Andean nativos with excessive polycythemia - efecct of hemodilution |
title_full |
Pulmonary gas exchange in Andean nativos with excessive polycythemia - efecct of hemodilution |
title_fullStr |
Pulmonary gas exchange in Andean nativos with excessive polycythemia - efecct of hemodilution |
title_full_unstemmed |
Pulmonary gas exchange in Andean nativos with excessive polycythemia - efecct of hemodilution |
title_sort |
pulmonary gas exchange in andean nativos with excessive polycythemia - efecct of hemodilution |
publisher |
J. Appl. Physiol. |
publishDate |
1988 |
url |
http://repositorio.umsa.bo/xmlui/handle/123456789/10553 |
work_keys_str_mv |
AT maniergerard pulmonarygasexchangeinandeannativoswithexcessivepolycythemiaefecctofhemodilution AT guenardherve pulmonarygasexchangeinandeannativoswithexcessivepolycythemiaefecctofhemodilution AT castaingyves pulmonarygasexchangeinandeannativoswithexcessivepolycythemiaefecctofhemodilution AT varenenicole pulmonarygasexchangeinandeannativoswithexcessivepolycythemiaefecctofhemodilution AT vargasenrique pulmonarygasexchangeinandeannativoswithexcessivepolycythemiaefecctofhemodilution |
_version_ |
1766395227427307520 |