Site-selective and inducible acylation of thrombin using aptamer-catalyst conjugates
Two acyl-transfer catalysts were conjugated to thrombin-binding DNA aptamers to acylate thrombin. Modification occurred site-selectively on Lys (≫Ser) residues proximal to the respective aptamer-thrombin interface, was selective for thrombin in the presence of other proteins, and the activity of both DNA-catalysts could be controlled by an external trigger.
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article/Letter to editor biblioteca |
| Language: | English |
| Subjects: | Life Science, |
| Online Access: | https://research.wur.nl/en/publications/site-selective-and-inducible-acylation-of-thrombin-using-aptamer- |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|