Analysis of factors and mechanisms that control growth in the genital disc of drosophila
The relation among proliferation and death duringgrowth is explained by the competition mechanism. This sees, the cells growth,in relation with their neighbors; if the rhythms of growth are notcoincidental, the lower growing cells are removed by apoptosis.There is aspecial type of cell competition called morphogenetic apoptosis.This occurs ifdiscontinuities in the growth /surviving signals Dpp/Wg are induced.Under thesecircumstances death mediated by the JNK mechanism is observed at the borders ofthe discontinuities. A tissue-physiologycal scenario for such discontinuitiescould be the time/place when Dpp and Wg expressions start. The differences inthe amount among, expressing and non expressing cells should be high at the beginningbut should decreased as development progress. In accordance, morphogeneticapoptosis must occurs at the borders of Dpp/Wg expressions. We tested this ideain the genital disc of Drosophilawhere the activation of Dpp occurs late in development, there is a celldivision arrest up to that time, and death plays roles. We center our analysisin the activities of Dpp, JNK, the pro-apoptotic genes RGH and the enzymes caspases.Our main results indicated there is cell competition/morphogenetic apoptosis atthe borders of Dpp expression, revealed principally not by the death but forits compensatory proliferation. The net balance among death/proliferationappeared cero, so physiologycal cell competition does not vary the size. Thelevels of active JNK and caspases are important for: the execution of death,the control of proliferation, and the occurrence of compensatory proliferation.TheJNK/capases activity over proliferation determines them as factors of cellcompetition.
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Format: | Fil: Fil: Arias, Carolina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Laboratorio de Genética; Argentina. biblioteca |
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2013
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Subjects: | Drosófila, Células, Dpp/Wg, JNK, |
Online Access: | http://hdl.handle.net/11086/547664 |
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dig-unc-ar-11086-5476642023-08-30T13:57:10Z Analysis of factors and mechanisms that control growth in the genital disc of drosophila Arias, Carolina Fussero, Gimena Zacharonok, Marcelo Drosófila Células Dpp/Wg JNK Fil: Fil: Arias, Carolina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Laboratorio de Genética; Argentina. Fil: Fil: Arias, Carolina. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Secretaría de Ciencia y Tecnología; Argentina. Fil: Fil: Fussero, Gimena. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Laboratorio de Genética; Argentina. Fil: Fil: Fussero, Gimena. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Secretaría de Ciencia y Tecnología; Argentina. Fil: Fil: Zacharonok, Marcelo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Laboratorio de Genética; Argentina. Fil: Fil: Zacharonok, Marcelo. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Secretaría de Ciencia y Tecnología; Argentina. The relation among proliferation and death duringgrowth is explained by the competition mechanism. This sees, the cells growth,in relation with their neighbors; if the rhythms of growth are notcoincidental, the lower growing cells are removed by apoptosis.There is aspecial type of cell competition called morphogenetic apoptosis.This occurs ifdiscontinuities in the growth /surviving signals Dpp/Wg are induced.Under thesecircumstances death mediated by the JNK mechanism is observed at the borders ofthe discontinuities. A tissue-physiologycal scenario for such discontinuitiescould be the time/place when Dpp and Wg expressions start. The differences inthe amount among, expressing and non expressing cells should be high at the beginningbut should decreased as development progress. In accordance, morphogeneticapoptosis must occurs at the borders of Dpp/Wg expressions. We tested this ideain the genital disc of Drosophilawhere the activation of Dpp occurs late in development, there is a celldivision arrest up to that time, and death plays roles. We center our analysisin the activities of Dpp, JNK, the pro-apoptotic genes RGH and the enzymes caspases.Our main results indicated there is cell competition/morphogenetic apoptosis atthe borders of Dpp expression, revealed principally not by the death but forits compensatory proliferation. The net balance among death/proliferationappeared cero, so physiologycal cell competition does not vary the size. Thelevels of active JNK and caspases are important for: the execution of death,the control of proliferation, and the occurrence of compensatory proliferation.TheJNK/capases activity over proliferation determines them as factors of cellcompetition. Fil: Arias, Carolina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Laboratorio de Genética; Argentina. Fil: Arias, Carolina. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Secretaría de Ciencia y Tecnología; Argentina. Fil: Fussero, Gimena. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Laboratorio de Genética; Argentina. Fil: Fussero, Gimena. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Secretaría de Ciencia y Tecnología; Argentina. Fil: Zacharonok, Marcelo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Laboratorio de Genética; Argentina. Fil: Zacharonok, Marcelo. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Secretaría de Ciencia y Tecnología; Argentina. Biología del Desarrollo 2023-06-06T14:18:34Z 2023-06-06T14:18:34Z 2013 conferenceObject http://hdl.handle.net/11086/547664 eng Attribution-NonCommercial-ShareAlike 4.0 International http://creativecommons.org/licenses/by-nc-sa/4.0/ Impreso |
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Drosófila Células Dpp/Wg JNK Drosófila Células Dpp/Wg JNK |
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Drosófila Células Dpp/Wg JNK Drosófila Células Dpp/Wg JNK Arias, Carolina Fussero, Gimena Zacharonok, Marcelo Analysis of factors and mechanisms that control growth in the genital disc of drosophila |
description |
The relation among proliferation and death duringgrowth is explained by the competition mechanism. This sees, the cells growth,in relation with their neighbors; if the rhythms of growth are notcoincidental, the lower growing cells are removed by apoptosis.There is aspecial type of cell competition called morphogenetic apoptosis.This occurs ifdiscontinuities in the growth /surviving signals Dpp/Wg are induced.Under thesecircumstances death mediated by the JNK mechanism is observed at the borders ofthe discontinuities. A tissue-physiologycal scenario for such discontinuitiescould be the time/place when Dpp and Wg expressions start. The differences inthe amount among, expressing and non expressing cells should be high at the beginningbut should decreased as development progress. In accordance, morphogeneticapoptosis must occurs at the borders of Dpp/Wg expressions. We tested this ideain the genital disc of Drosophilawhere the activation of Dpp occurs late in development, there is a celldivision arrest up to that time, and death plays roles. We center our analysisin the activities of Dpp, JNK, the pro-apoptotic genes RGH and the enzymes caspases.Our main results indicated there is cell competition/morphogenetic apoptosis atthe borders of Dpp expression, revealed principally not by the death but forits compensatory proliferation. The net balance among death/proliferationappeared cero, so physiologycal cell competition does not vary the size. Thelevels of active JNK and caspases are important for: the execution of death,the control of proliferation, and the occurrence of compensatory proliferation.TheJNK/capases activity over proliferation determines them as factors of cellcompetition. |
format |
Fil: Fil: Arias, Carolina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Laboratorio de Genética; Argentina. |
topic_facet |
Drosófila Células Dpp/Wg JNK |
author |
Arias, Carolina Fussero, Gimena Zacharonok, Marcelo |
author_facet |
Arias, Carolina Fussero, Gimena Zacharonok, Marcelo |
author_sort |
Arias, Carolina |
title |
Analysis of factors and mechanisms that control growth in the genital disc of drosophila |
title_short |
Analysis of factors and mechanisms that control growth in the genital disc of drosophila |
title_full |
Analysis of factors and mechanisms that control growth in the genital disc of drosophila |
title_fullStr |
Analysis of factors and mechanisms that control growth in the genital disc of drosophila |
title_full_unstemmed |
Analysis of factors and mechanisms that control growth in the genital disc of drosophila |
title_sort |
analysis of factors and mechanisms that control growth in the genital disc of drosophila |
publishDate |
2013 |
url |
http://hdl.handle.net/11086/547664 |
work_keys_str_mv |
AT ariascarolina analysisoffactorsandmechanismsthatcontrolgrowthinthegenitaldiscofdrosophila AT fusserogimena analysisoffactorsandmechanismsthatcontrolgrowthinthegenitaldiscofdrosophila AT zacharonokmarcelo analysisoffactorsandmechanismsthatcontrolgrowthinthegenitaldiscofdrosophila |
_version_ |
1775947105585594368 |