Dose point kernel calculation and modelling with nuclear medicine dosimetry purposes

Dose point kernel calculation and modelling with nuclear medicine dosimetry purposes

Trabajo presentado en el X Latin American Symposium on Nuclear Physics and Applications (X LASNPA), 1-6 diciembre 2013. Montevideo, Uruguay.

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Main Authors: Scarinci, Ignacio Emanuel, Valente, Mauro Andrés, Pérez, Pedro Antonio
Format: article biblioteca
Language:eng
Published: 2014
Subjects:Dosimetría, Medicina nuclear, Dose point kernel, Dosimetry, Nuclear medicine,
Online Access:http://hdl.handle.net/11086/20150
https://doi.org/10.22323/1.194.0084
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spelling dig-unc-ar-11086-201502022-10-13T11:07:07Z Dose point kernel calculation and modelling with nuclear medicine dosimetry purposes Scarinci, Ignacio Emanuel Valente, Mauro Andrés Pérez, Pedro Antonio Dosimetría Medicina nuclear Dose point kernel Dosimetry Nuclear medicine Trabajo presentado en el X Latin American Symposium on Nuclear Physics and Applications (X LASNPA), 1-6 diciembre 2013. Montevideo, Uruguay. Monoclonal labeled antibodies are commonly used for radioimmunotherapy purposes in nuclear medicine. The procedure is based on the deposition of specific radiactivity concentrations on tumoral regions with the aim of treating tumoral diseases. Patient metabolism produces nonuniform organ activity distributions, but there are some traditional approaches for internal dosimetry assuming uniform spatial distribution of activity within organ or tissues of interest. When patient-specific dosimetry needs to be performed, these methods may involve non negligible uncertainties. Treatment evaluation and preliminary planning require the estimation of absorbed dose distribution and this goal can be achieved by different approaches. For example, it is possible to perform Monte Carlo simulations for numerical dose assessments; whereas analytical calculations can be carried out by convolution of activity distribution using Dose Point Kernels. Besides, it is often found that some internal dosimetry approaches assume simplified conditions of infinite ad homogeneous media for radiation transport and corresponding dose deposition. This work presents a method for internal dosimetry in nuclear medicine by means of Dose Point Kernels. The proposed method is capable of performing calculations over heterogeneous systems. The starting point is a set of suitable kernels previously calculated by Monte Carlo simulations in different tissues. Thus, dose distribution is obtained by the proposed hybrid approach involving both numerical and analytical methods. Preliminary tests on simplified geometries demonstrated the capability of the developed technique; whereas computation of patient-specific internal dosimetry suggest promising performance. Hence, the developed method may constitute a valuable tool for nuclear medicine dosimetry purposes. publishedVersion Fil: Scarinci, Ignacio Emanuel. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física. Laboratorio de Investigación e Instrumentación en Física Aplicada a la Medicina e Imágenes por Rayos X; Argentina. Fil: Valente, Mauro Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Física Enrique Gaviola; Argentina. Fil: Valente, Mauro Andrés. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física. Laboratorio de Investigación e Instrumentación en Física Aplicada a la Medicina e Imágenes por Rayos X; Argentina. Fil: Pérez, Pedro Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Física Enrique Gaviola; Argentina. Fil: Pérez, Pedro Antonio. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física. Laboratorio de Investigación e Instrumentación en Física Aplicada a la Medicina e Imágenes por Rayos X; Argentina. Fil: Pérez, Pedro Antonio. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Físico-Químicas y Naturales. Departamento de Física; Argentina. Física Atómica, Molecular y Química (física de átomos y moléculas incluyendo colisión, interacción con radiación, resonancia magnética, Moessbauer Efecto.) 2021-09-06T17:48:53Z 2021-09-06T17:48:53Z 2014 article Scarinci, I. E., Valente, M. A. y Pérez, P. A. (2014). Dose point kernel calculation and modelling with nuclear medicine dosimetry purposes. Proceedings of Science, 1-7. https://doi.org/10.22323/1.194.0084 http://hdl.handle.net/11086/20150 https://doi.org/10.22323/1.194.0084 eng Attribution-NonCommercial-ShareAlike 1.0 Generic https://creativecommons.org/licenses/by-nc-sa/1.0/ Electrónico y/o Digital ISSN 1824-8039
institution UNC AR
collection DSpace
country Argentina
countrycode AR
component Bibliográfico
access En linea
databasecode dig-unc-ar
tag biblioteca
region America del Sur
libraryname Biblioteca 'Ing. Agrónomo Moisés Farber' de la Facultad de Ciencias Agropecuarias
language eng
topic Dosimetría
Medicina nuclear
Dose point kernel
Dosimetry
Nuclear medicine
Dosimetría
Medicina nuclear
Dose point kernel
Dosimetry
Nuclear medicine
spellingShingle Dosimetría
Medicina nuclear
Dose point kernel
Dosimetry
Nuclear medicine
Dosimetría
Medicina nuclear
Dose point kernel
Dosimetry
Nuclear medicine
Scarinci, Ignacio Emanuel
Valente, Mauro Andrés
Pérez, Pedro Antonio
Dose point kernel calculation and modelling with nuclear medicine dosimetry purposes
description Trabajo presentado en el X Latin American Symposium on Nuclear Physics and Applications (X LASNPA), 1-6 diciembre 2013. Montevideo, Uruguay.
format article
topic_facet Dosimetría
Medicina nuclear
Dose point kernel
Dosimetry
Nuclear medicine
author Scarinci, Ignacio Emanuel
Valente, Mauro Andrés
Pérez, Pedro Antonio
author_facet Scarinci, Ignacio Emanuel
Valente, Mauro Andrés
Pérez, Pedro Antonio
author_sort Scarinci, Ignacio Emanuel
title Dose point kernel calculation and modelling with nuclear medicine dosimetry purposes
title_short Dose point kernel calculation and modelling with nuclear medicine dosimetry purposes
title_full Dose point kernel calculation and modelling with nuclear medicine dosimetry purposes
title_fullStr Dose point kernel calculation and modelling with nuclear medicine dosimetry purposes
title_full_unstemmed Dose point kernel calculation and modelling with nuclear medicine dosimetry purposes
title_sort dose point kernel calculation and modelling with nuclear medicine dosimetry purposes
publishDate 2014
url http://hdl.handle.net/11086/20150
https://doi.org/10.22323/1.194.0084
work_keys_str_mv AT scarinciignacioemanuel dosepointkernelcalculationandmodellingwithnuclearmedicinedosimetrypurposes
AT valentemauroandres dosepointkernelcalculationandmodellingwithnuclearmedicinedosimetrypurposes
AT perezpedroantonio dosepointkernelcalculationandmodellingwithnuclearmedicinedosimetrypurposes
_version_ 1756009589032091648

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