From reactive species to disease development: Effect of oxidants and antioxidants on the cellular biomarkers
The influence of modern lifestyle, diet, exposure to chemicals such as phytosanitary substances, together with sedentary lifestyles and lack of exercise play an important role in inducing reactive stress (RS) and disease. The imbalance in the production and scavenging of free radicals and the induction of RS (oxidative, nitrosative, and halogenative) plays an essential role in the etiology of various chronic pathologies, such as cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. The implication of free radicals and reactive species injury in metabolic disturbances and the onset of many diseases have been accumulating for several decades, and are now accepted as a major cause of many chronic diseases. Exposure to elevated levels of free radicals can cause molecular structural impact on proteins, lipids, and DNA, as well as functional alteration of enzyme homeostasis, leading to aberrations in gene expression. Endogenous depletion of antioxidant enzymes can be mitigated using exogenous antioxidants. The current interest in the use of exogenous antioxidants as adjunctive agents for the treatment of human diseases allows a better understanding of these diseases, facilitating the development of new therapeutic agents with antioxidant activity to improve the treatment of various diseases. Here we examine the role that RS play in the initiation of disease and in the reactivity of free radicals and RS in organic and inorganic cellular components.
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Language: | English |
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John Wiley & Sons
2023-07-12
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Subjects: | Antioxidants, chronic pathologies, free radicals, proteostasis failure, reactive stress, Ensure healthy lives and promote well-being for all at all ages, |
Online Access: | http://hdl.handle.net/10261/341534 |
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dig-ipna-es-10261-3415342024-01-03T13:11:29Z From reactive species to disease development: Effect of oxidants and antioxidants on the cellular biomarkers Curieses Andrés, Celia María Pérez de Lastra, José Manuel Andrés Juan, Celia Plou Gasca, Francisco José Pérez-Lebeña, Eduardo Agencia Canaria de Investigación, Innovación y Sociedad de la Información Ministerio de Economía y Competitividad (España) Ministerio de Ciencia e Innovación (España) Antioxidants chronic pathologies free radicals proteostasis failure reactive stress Ensure healthy lives and promote well-being for all at all ages The influence of modern lifestyle, diet, exposure to chemicals such as phytosanitary substances, together with sedentary lifestyles and lack of exercise play an important role in inducing reactive stress (RS) and disease. The imbalance in the production and scavenging of free radicals and the induction of RS (oxidative, nitrosative, and halogenative) plays an essential role in the etiology of various chronic pathologies, such as cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. The implication of free radicals and reactive species injury in metabolic disturbances and the onset of many diseases have been accumulating for several decades, and are now accepted as a major cause of many chronic diseases. Exposure to elevated levels of free radicals can cause molecular structural impact on proteins, lipids, and DNA, as well as functional alteration of enzyme homeostasis, leading to aberrations in gene expression. Endogenous depletion of antioxidant enzymes can be mitigated using exogenous antioxidants. The current interest in the use of exogenous antioxidants as adjunctive agents for the treatment of human diseases allows a better understanding of these diseases, facilitating the development of new therapeutic agents with antioxidant activity to improve the treatment of various diseases. Here we examine the role that RS play in the initiation of disease and in the reactivity of free radicals and RS in organic and inorganic cellular components. This research was funded by “Agencia Canaria de Investigación, Innovación y Sociedad de la Información (ACIISI) del Gobierno de Canarias”, project ProID2020010134, the Spanish Ministry of Economy and Competitiveness (Grant PID2019-105838RB-C31) and the State Plan for Scientific, Technical Research and Innovation 2021−2023 from the Spanish Ministry of Science and Innovation (project PLEC2022-009507). Peer reviewed 2024-01-03T13:11:29Z 2024-01-03T13:11:29Z 2023-07-12 artículo Journal of Biochemical and Molecular Toxicology, 37(11): 1-17 (2023) 1095-6670 http://hdl.handle.net/10261/341534 10.1002/jbt.23455 1099-0461 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105838RB-C31/ES/SINTESIS ENZIMATICA, CARACTERIZACION Y BIOACTIVIDAD DE OLIGOSACARIDOS CARGADOS Y GLICOSIDOS DE POLIFENOLES/ info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PLEC2022-009507 Publisher's version https://doi.org/10.1002/jbt.23455 Sí open John Wiley & Sons |
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Antioxidants chronic pathologies free radicals proteostasis failure reactive stress Ensure healthy lives and promote well-being for all at all ages Antioxidants chronic pathologies free radicals proteostasis failure reactive stress Ensure healthy lives and promote well-being for all at all ages |
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Antioxidants chronic pathologies free radicals proteostasis failure reactive stress Ensure healthy lives and promote well-being for all at all ages Antioxidants chronic pathologies free radicals proteostasis failure reactive stress Ensure healthy lives and promote well-being for all at all ages Curieses Andrés, Celia María Pérez de Lastra, José Manuel Andrés Juan, Celia Plou Gasca, Francisco José Pérez-Lebeña, Eduardo From reactive species to disease development: Effect of oxidants and antioxidants on the cellular biomarkers |
description |
The influence of modern lifestyle, diet, exposure to chemicals such as phytosanitary substances, together with sedentary lifestyles and lack of exercise play an important role in inducing reactive stress (RS) and disease. The imbalance in the production and scavenging of free radicals and the induction of RS (oxidative, nitrosative, and halogenative) plays an essential role in the etiology of various chronic pathologies, such as cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. The implication of free radicals and reactive species injury in metabolic disturbances and the onset of many diseases have been accumulating for several decades, and are now accepted as a major cause of many chronic diseases. Exposure to elevated levels of free radicals can cause molecular structural impact on proteins, lipids, and DNA, as well as functional alteration of enzyme homeostasis, leading to aberrations in gene expression. Endogenous depletion of antioxidant enzymes can be mitigated using exogenous antioxidants. The current interest in the use of exogenous antioxidants as adjunctive agents for the treatment of human diseases allows a better understanding of these diseases, facilitating the development of new therapeutic agents with antioxidant activity to improve the treatment of various diseases. Here we examine the role that RS play in the initiation of disease and in the reactivity of free radicals and RS in organic and inorganic cellular components. |
author2 |
Agencia Canaria de Investigación, Innovación y Sociedad de la Información |
author_facet |
Agencia Canaria de Investigación, Innovación y Sociedad de la Información Curieses Andrés, Celia María Pérez de Lastra, José Manuel Andrés Juan, Celia Plou Gasca, Francisco José Pérez-Lebeña, Eduardo |
format |
artículo |
topic_facet |
Antioxidants chronic pathologies free radicals proteostasis failure reactive stress Ensure healthy lives and promote well-being for all at all ages |
author |
Curieses Andrés, Celia María Pérez de Lastra, José Manuel Andrés Juan, Celia Plou Gasca, Francisco José Pérez-Lebeña, Eduardo |
author_sort |
Curieses Andrés, Celia María |
title |
From reactive species to disease development: Effect of oxidants and antioxidants on the cellular biomarkers |
title_short |
From reactive species to disease development: Effect of oxidants and antioxidants on the cellular biomarkers |
title_full |
From reactive species to disease development: Effect of oxidants and antioxidants on the cellular biomarkers |
title_fullStr |
From reactive species to disease development: Effect of oxidants and antioxidants on the cellular biomarkers |
title_full_unstemmed |
From reactive species to disease development: Effect of oxidants and antioxidants on the cellular biomarkers |
title_sort |
from reactive species to disease development: effect of oxidants and antioxidants on the cellular biomarkers |
publisher |
John Wiley & Sons |
publishDate |
2023-07-12 |
url |
http://hdl.handle.net/10261/341534 |
work_keys_str_mv |
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1792484813607796736 |