Teleost Piscidins—In Silico Perspective of Natural Peptide Antibiotics from Marine Sources
Fish, like all other animals, are exposed to constant contact with microbes, both on their skin and on the surfaces of their respiratory and digestive systems. Fish have a system of non-specific immune responses that provides them with initial protection against infection and allows them to survive under normal conditions despite the presence of these potential invaders. However, fish are less protected against invading diseases than other marine vertebrates because their epidermal surface, composed primarily of living cells, lacks the keratinized skin that serves as an efficient natural barrier in other marine vertebrates. Antimicrobial peptides (AMPs) are one type of innate immune protection present in all life forms. AMPs have been shown to have a broader range of biological effects than conventional antibiotics, including antibacterial, antiviral, antiprotozoal, and antifungal effects. Although other AMPs, such as defensins and hepcidins, are found in all vertebrates and are relatively well conserved, piscidins are found exclusively in Teleost fish and are not found in any other animal. Therefore, there is less information on the expression and bioactivity of piscidins than on other AMPs. Piscidins are highly effective against Gram-positive and Gram-negative bacteria that cause disease in fish and humans and have the potential to be used as pharmacological anti-infectives in biomedicine and aquaculture. To better understand the potential benefits and limitations of using these peptides as therapeutic agents, we are conducting a comprehensive study of the Teleost piscidins included in the “reviewed” category of the UniProt database using bioinformatics tools. They all have amphipathic alpha-helical structures. The amphipathic architecture of piscidin peptides and positively charged residues influence their antibacterial activity. These alpha-helices are intriguing antimicrobial drugs due to their stability in high-salt and metal environments. New treatments for multidrug-resistant bacteria, cancer, and inflammation may be inspired by piscidin peptides.
Main Authors: | , , , , , |
---|---|
Other Authors: | |
Format: | artículo biblioteca |
Language: | English |
Published: |
Multidisciplinary Digital Publishing Institute
2023-05-05
|
Subjects: | Antimicrobial peptide, Fish, Piscidin, Teleost, Innate immunity, Docking, In silico, Immunomodulation, |
Online Access: | http://hdl.handle.net/10261/310502 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
dig-ipna-es-10261-310502 |
---|---|
record_format |
koha |
spelling |
dig-ipna-es-10261-3105022023-06-08T14:38:21Z Teleost Piscidins—In Silico Perspective of Natural Peptide Antibiotics from Marine Sources Asensio-Calavia, Patricia González-Acosta, Sergio Otazo-Pérez, Andrea López, Manuel R. Morales-delaNuez, Antonio Pérez de Lastra, José Manuel Gobierno de Canarias Ministerio de Ciencia e Innovación (España) Antimicrobial peptide Fish Piscidin Teleost Innate immunity Docking In silico Immunomodulation Fish, like all other animals, are exposed to constant contact with microbes, both on their skin and on the surfaces of their respiratory and digestive systems. Fish have a system of non-specific immune responses that provides them with initial protection against infection and allows them to survive under normal conditions despite the presence of these potential invaders. However, fish are less protected against invading diseases than other marine vertebrates because their epidermal surface, composed primarily of living cells, lacks the keratinized skin that serves as an efficient natural barrier in other marine vertebrates. Antimicrobial peptides (AMPs) are one type of innate immune protection present in all life forms. AMPs have been shown to have a broader range of biological effects than conventional antibiotics, including antibacterial, antiviral, antiprotozoal, and antifungal effects. Although other AMPs, such as defensins and hepcidins, are found in all vertebrates and are relatively well conserved, piscidins are found exclusively in Teleost fish and are not found in any other animal. Therefore, there is less information on the expression and bioactivity of piscidins than on other AMPs. Piscidins are highly effective against Gram-positive and Gram-negative bacteria that cause disease in fish and humans and have the potential to be used as pharmacological anti-infectives in biomedicine and aquaculture. To better understand the potential benefits and limitations of using these peptides as therapeutic agents, we are conducting a comprehensive study of the Teleost piscidins included in the “reviewed” category of the UniProt database using bioinformatics tools. They all have amphipathic alpha-helical structures. The amphipathic architecture of piscidin peptides and positively charged residues influence their antibacterial activity. These alpha-helices are intriguing antimicrobial drugs due to their stability in high-salt and metal environments. New treatments for multidrug-resistant bacteria, cancer, and inflammation may be inspired by piscidin peptides. This research was funded “Agencia Canaria de Investigación, Innovación y Sociedad de la Información (ACIISI) del Gobierno de Canarias”, Project ProID2020010134 “Bioprospección y biotecnología en el descubrimiento de péptidos antimicrobianos contra patógenos resistentes” and the State Plan for Scientific, Technical Research and Innovation 2021–2023 from the Spanish Ministry of Science and Innovation (project PLEC2022-009507). Thesis/Work co-financed by the Canary Islands Agency for Research, Innovation and Information Society of the Regional Ministry of Economy, Knowledge and Employment and by the European Social Fund (ESF) Canary Islands Integrated Operational Program 2014–2020, Axis 3 Priority Theme 74 (85%). Peer reviewed 2023-06-04T10:19:01Z 2023-06-04T10:19:01Z 2023-05-05 2023-06-04T10:19:01Z artículo http://purl.org/coar/resource_type/c_6501 Antibiotics 12(5): 855 (2023) http://hdl.handle.net/10261/310502 10.3390/antibiotics12050855 2079-6382 en Publisher's version https://doi.org/10.3390/antibiotics12050855 Sí open application/pdf Multidisciplinary Digital Publishing Institute |
institution |
IPNA ES |
collection |
DSpace |
country |
España |
countrycode |
ES |
component |
Bibliográfico |
access |
En linea |
databasecode |
dig-ipna-es |
tag |
biblioteca |
region |
Europa del Sur |
libraryname |
Biblioteca del IPNA España |
language |
English |
topic |
Antimicrobial peptide Fish Piscidin Teleost Innate immunity Docking In silico Immunomodulation Antimicrobial peptide Fish Piscidin Teleost Innate immunity Docking In silico Immunomodulation |
spellingShingle |
Antimicrobial peptide Fish Piscidin Teleost Innate immunity Docking In silico Immunomodulation Antimicrobial peptide Fish Piscidin Teleost Innate immunity Docking In silico Immunomodulation Asensio-Calavia, Patricia González-Acosta, Sergio Otazo-Pérez, Andrea López, Manuel R. Morales-delaNuez, Antonio Pérez de Lastra, José Manuel Teleost Piscidins—In Silico Perspective of Natural Peptide Antibiotics from Marine Sources |
description |
Fish, like all other animals, are exposed to constant contact with microbes, both on their skin and on the surfaces of their respiratory and digestive systems. Fish have a system of non-specific immune responses that provides them with initial protection against infection and allows them to survive under normal conditions despite the presence of these potential invaders. However, fish are less protected against invading diseases than other marine vertebrates because their epidermal surface, composed primarily of living cells, lacks the keratinized skin that serves as an efficient natural barrier in other marine vertebrates. Antimicrobial peptides (AMPs) are one type of innate immune protection present in all life forms. AMPs have been shown to have a broader range of biological effects than conventional antibiotics, including antibacterial, antiviral, antiprotozoal, and antifungal effects. Although other AMPs, such as defensins and hepcidins, are found in all vertebrates and are relatively well conserved, piscidins are found exclusively in Teleost fish and are not found in any other animal. Therefore, there is less information on the expression and bioactivity of piscidins than on other AMPs. Piscidins are highly effective against Gram-positive and Gram-negative bacteria that cause disease in fish and humans and have the potential to be used as pharmacological anti-infectives in biomedicine and aquaculture. To better understand the potential benefits and limitations of using these peptides as therapeutic agents, we are conducting a comprehensive study of the Teleost piscidins included in the “reviewed” category of the UniProt database using bioinformatics tools. They all have amphipathic alpha-helical structures. The amphipathic architecture of piscidin peptides and positively charged residues influence their antibacterial activity. These alpha-helices are intriguing antimicrobial drugs due to their stability in high-salt and metal environments. New treatments for multidrug-resistant bacteria, cancer, and inflammation may be inspired by piscidin peptides. |
author2 |
Gobierno de Canarias |
author_facet |
Gobierno de Canarias Asensio-Calavia, Patricia González-Acosta, Sergio Otazo-Pérez, Andrea López, Manuel R. Morales-delaNuez, Antonio Pérez de Lastra, José Manuel |
format |
artículo |
topic_facet |
Antimicrobial peptide Fish Piscidin Teleost Innate immunity Docking In silico Immunomodulation |
author |
Asensio-Calavia, Patricia González-Acosta, Sergio Otazo-Pérez, Andrea López, Manuel R. Morales-delaNuez, Antonio Pérez de Lastra, José Manuel |
author_sort |
Asensio-Calavia, Patricia |
title |
Teleost Piscidins—In Silico Perspective of Natural Peptide Antibiotics from Marine Sources |
title_short |
Teleost Piscidins—In Silico Perspective of Natural Peptide Antibiotics from Marine Sources |
title_full |
Teleost Piscidins—In Silico Perspective of Natural Peptide Antibiotics from Marine Sources |
title_fullStr |
Teleost Piscidins—In Silico Perspective of Natural Peptide Antibiotics from Marine Sources |
title_full_unstemmed |
Teleost Piscidins—In Silico Perspective of Natural Peptide Antibiotics from Marine Sources |
title_sort |
teleost piscidins—in silico perspective of natural peptide antibiotics from marine sources |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2023-05-05 |
url |
http://hdl.handle.net/10261/310502 |
work_keys_str_mv |
AT asensiocalaviapatricia teleostpiscidinsinsilicoperspectiveofnaturalpeptideantibioticsfrommarinesources AT gonzalezacostasergio teleostpiscidinsinsilicoperspectiveofnaturalpeptideantibioticsfrommarinesources AT otazoperezandrea teleostpiscidinsinsilicoperspectiveofnaturalpeptideantibioticsfrommarinesources AT lopezmanuelr teleostpiscidinsinsilicoperspectiveofnaturalpeptideantibioticsfrommarinesources AT moralesdelanuezantonio teleostpiscidinsinsilicoperspectiveofnaturalpeptideantibioticsfrommarinesources AT perezdelastrajosemanuel teleostpiscidinsinsilicoperspectiveofnaturalpeptideantibioticsfrommarinesources |
_version_ |
1777669926180356096 |