New insights into the structure-cytotoxicity relationship of spirostan saponins and related glycosides

A variety of spirostan saponins and related glycosides were synthesized and evaluated for their cytotoxicity against the human myeloid leukemia cell line (HL-60). A linear glycosylation strategy allowed for accessing a variety of functionalization patterns at both the spirostanic and the saccharide moieties, which provides new information regarding the structure-cytotoxicity relationship of this family of steroidal glycosides. Intriguing results were achieved with respect to hecogenyl and 5α-hydroxy-laxogenyl β-chacotriosides, turning out to be the former very cytotoxic and the latter no cytotoxic at all. Importantly, the partially pivaloylated β-d-glucosides of 5α-hydroxy-laxogenin were the most potent cytotoxic compounds among all tested glycosides. This comprises the first report on acylated spirostanyl glucosides displaying significant cytotoxicity, and therefore, it opens up new opportunities toward the development of saponin analogues as anticancer agents.

Bibliographic Details

Main Authors:	Pérez-Labrada, Karell, Brouard, Ignacio, Estévez, Sara, Marrero, María Teresa, Estévez, Francisco, Bermejo, Jaime, Rivera, Daniel G.
Other Authors:	Consejo Superior de Investigaciones Científicas (España)
Format:	artículo biblioteca
Published:	Elsevier 2012-04-15
Subjects:	Steroids, Saponins, Structure–activity relationship, Cytotoxicity, HL-60 cell,
Online Access:	http://hdl.handle.net/10261/199546 http://dx.doi.org/10.13039/501100003767 http://dx.doi.org/10.13039/501100003339 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000780
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