Novel 'customizable units' for the generation of unusual amino acids in potential antimicrobial peptides
Trabajo presentado en la IV International Conference on Antimicrobial Research ICAR, celebrada en Torremolinos (España) del 29 de junio al 1 de julio de 2016.
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| Format: | comunicación de congreso biblioteca |
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2016-06-29
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| Subjects: | Antimicrobial activity, Peptide synthesis, Antimicrobial peptides, Site-selective peptide modification, |
| Online Access: | http://hdl.handle.net/10261/184628 |
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dig-ipna-es-10261-1846282019-11-14T14:18:13Z Novel 'customizable units' for the generation of unusual amino acids in potential antimicrobial peptides Boto, Alicia González Martín, Concepción C. Rodríguez Paz, Nieves Hernández, Dácil Saavedra, Carlos Javier Pérez de Lastra, José Manuel Antimicrobial activity Peptide synthesis Antimicrobial peptides Site-selective peptide modification Trabajo presentado en la IV International Conference on Antimicrobial Research ICAR, celebrada en Torremolinos (España) del 29 de junio al 1 de julio de 2016. Host-defense peptides (HDP) present many advantages for the treatment of microbial diseases, such as: 1) broad spectrum of activity, 2) unlike classic antibiotics, HDP do not induce resistance; 3) They act synergically with conventional antibiotics; 4) They neutralize endotoxins and are active in animal models. However, it is considered that current natural antimicrobial peptides are not suitable for drug development due to stability and biodisponibility issues. In order to improve their stability, reduce possible toxicity and/or decrease production costs, the production of analogues by chemical modification of “parent” peptides or by biotechnology should be implemented.1 This communication describes the site-selective modification of peptides using different “Customizable Units”,2 derived from serine and threonine, which allow the introduction of a diversity of unnatural chains. The antimicrobial activity of these peptides will be commented as well. Peer Reviewed 2019-06-21T12:06:17Z 2019-06-21T12:06:17Z 2016-06-29 2019-06-21T12:06:17Z comunicación de congreso http://purl.org/coar/resource_type/c_5794 IV International Conference on Antimicrobial Research ICAR (2016) http://hdl.handle.net/10261/184628 Sí none |
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IPNA ES |
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España |
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ES |
| component |
Bibliográfico |
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| databasecode |
dig-ipna-es |
| tag |
biblioteca |
| region |
Europa del Sur |
| libraryname |
Biblioteca del IPNA España |
| topic |
Antimicrobial activity Peptide synthesis Antimicrobial peptides Site-selective peptide modification Antimicrobial activity Peptide synthesis Antimicrobial peptides Site-selective peptide modification |
| spellingShingle |
Antimicrobial activity Peptide synthesis Antimicrobial peptides Site-selective peptide modification Antimicrobial activity Peptide synthesis Antimicrobial peptides Site-selective peptide modification Boto, Alicia González Martín, Concepción C. Rodríguez Paz, Nieves Hernández, Dácil Saavedra, Carlos Javier Pérez de Lastra, José Manuel Novel 'customizable units' for the generation of unusual amino acids in potential antimicrobial peptides |
| description |
Trabajo presentado en la IV International Conference on Antimicrobial Research ICAR, celebrada en Torremolinos (España) del 29 de junio al 1 de julio de 2016. |
| format |
comunicación de congreso |
| topic_facet |
Antimicrobial activity Peptide synthesis Antimicrobial peptides Site-selective peptide modification |
| author |
Boto, Alicia González Martín, Concepción C. Rodríguez Paz, Nieves Hernández, Dácil Saavedra, Carlos Javier Pérez de Lastra, José Manuel |
| author_facet |
Boto, Alicia González Martín, Concepción C. Rodríguez Paz, Nieves Hernández, Dácil Saavedra, Carlos Javier Pérez de Lastra, José Manuel |
| author_sort |
Boto, Alicia |
| title |
Novel 'customizable units' for the generation of unusual amino acids in potential antimicrobial peptides |
| title_short |
Novel 'customizable units' for the generation of unusual amino acids in potential antimicrobial peptides |
| title_full |
Novel 'customizable units' for the generation of unusual amino acids in potential antimicrobial peptides |
| title_fullStr |
Novel 'customizable units' for the generation of unusual amino acids in potential antimicrobial peptides |
| title_full_unstemmed |
Novel 'customizable units' for the generation of unusual amino acids in potential antimicrobial peptides |
| title_sort |
novel 'customizable units' for the generation of unusual amino acids in potential antimicrobial peptides |
| publishDate |
2016-06-29 |
| url |
http://hdl.handle.net/10261/184628 |
| work_keys_str_mv |
AT botoalicia novelcustomizableunitsforthegenerationofunusualaminoacidsinpotentialantimicrobialpeptides AT gonzalezmartinconcepcionc novelcustomizableunitsforthegenerationofunusualaminoacidsinpotentialantimicrobialpeptides AT rodriguezpaznieves novelcustomizableunitsforthegenerationofunusualaminoacidsinpotentialantimicrobialpeptides AT hernandezdacil novelcustomizableunitsforthegenerationofunusualaminoacidsinpotentialantimicrobialpeptides AT saavedracarlosjavier novelcustomizableunitsforthegenerationofunusualaminoacidsinpotentialantimicrobialpeptides AT perezdelastrajosemanuel novelcustomizableunitsforthegenerationofunusualaminoacidsinpotentialantimicrobialpeptides |
| _version_ |
1777669793256570880 |