Quasispecies dynamics and RNA virus extinction
The extinction of foot-and-mouth disease virus (FMDV) is strongly influenced by mutation rates, types of mutations, relative viral fitness and virus population regimens during infection. Here we review experimental results and theoretical models that describe a contrast between the effective extinction of FMDV subjected to increased mutagenesis, and the remarkable resistance to extinction of the same and related FMDV clones subjected to serial bottleneck events. The results suggest procedures to master key parameters to develop effective antiviral strategies based on virus entry into error catastrophe. © 2004 Elsevier B.V. All rights reserved.
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2005
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dig-inia-es-20.500.12792-11152020-12-15T09:14:50Z Quasispecies dynamics and RNA virus extinction Domingo, E. Escarmís, C. Lázaro, E. Manrubia, S. C. The extinction of foot-and-mouth disease virus (FMDV) is strongly influenced by mutation rates, types of mutations, relative viral fitness and virus population regimens during infection. Here we review experimental results and theoretical models that describe a contrast between the effective extinction of FMDV subjected to increased mutagenesis, and the remarkable resistance to extinction of the same and related FMDV clones subjected to serial bottleneck events. The results suggest procedures to master key parameters to develop effective antiviral strategies based on virus entry into error catastrophe. © 2004 Elsevier B.V. All rights reserved. 2020-10-22T11:45:32Z 2020-10-22T11:45:32Z 2005 review http://hdl.handle.net/20.500.12792/1115 10.1016/j.virusres.2004.11.003 eng Attribution-NonCommercial-ShareAlike 4.0 International http://creativecommons.org/licenses/by-nc-sa/4.0/ open access |
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The extinction of foot-and-mouth disease virus (FMDV) is strongly influenced by mutation rates, types of mutations, relative viral fitness and virus population regimens during infection. Here we review experimental results and theoretical models that describe a contrast between the effective extinction of FMDV subjected to increased mutagenesis, and the remarkable resistance to extinction of the same and related FMDV clones subjected to serial bottleneck events. The results suggest procedures to master key parameters to develop effective antiviral strategies based on virus entry into error catastrophe. © 2004 Elsevier B.V. All rights reserved. |
| format |
review |
| author |
Domingo, E. Escarmís, C. Lázaro, E. Manrubia, S. C. |
| spellingShingle |
Domingo, E. Escarmís, C. Lázaro, E. Manrubia, S. C. Quasispecies dynamics and RNA virus extinction |
| author_facet |
Domingo, E. Escarmís, C. Lázaro, E. Manrubia, S. C. |
| author_sort |
Domingo, E. |
| title |
Quasispecies dynamics and RNA virus extinction |
| title_short |
Quasispecies dynamics and RNA virus extinction |
| title_full |
Quasispecies dynamics and RNA virus extinction |
| title_fullStr |
Quasispecies dynamics and RNA virus extinction |
| title_full_unstemmed |
Quasispecies dynamics and RNA virus extinction |
| title_sort |
quasispecies dynamics and rna virus extinction |
| publishDate |
2005 |
| url |
http://hdl.handle.net/20.500.12792/1115 |
| work_keys_str_mv |
AT domingoe quasispeciesdynamicsandrnavirusextinction AT escarmisc quasispeciesdynamicsandrnavirusextinction AT lazaroe quasispeciesdynamicsandrnavirusextinction AT manrubiasc quasispeciesdynamicsandrnavirusextinction |
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1758005075225083904 |