Epidemiological impacts of attenuated African swine fever virus circulating in wild boar populations
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Elsevier BV
2023-09
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| Subjects: | ASF transmission, African Swine Fever Virus, Disease dynamics, Modelling, Moderate or low virulence, http://metadata.un.org/sdg/1, End poverty in all its forms everywhere, |
| Online Access: | http://hdl.handle.net/10261/334568 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100002911 https://api.elsevier.com/content/abstract/scopus_id/85166171675 |
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dig-inia-es-10261-3345682024-10-27T21:46:42Z Epidemiological impacts of attenuated African swine fever virus circulating in wild boar populations Martínez Avilés, Marta Bosch, Jaime Ivorra, Benjamin Ramos, Ángel Manuel Satoshi Ito Barasona, Jose A. Sánchez-Vizcaíno, J. M. European Commission Ministerio de Ciencia e Innovación (España) Universidad Complutense de Madrid Martínez Avilés, Marta [0000-0002-7880-3829] Ivorra, Benjamin [0000-0002-0536-7149] Ramos, Ángel Manuel [0000-0002-7882-0725] Satoshi Ito [0000-0001-9653-7520] Barasona, Jose A. [0000-0003-4066-8454] Sánchez-Vizcaíno, J. M. [0000-0002-1502-8968] Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] ASF transmission African Swine Fever Virus Disease dynamics Modelling Moderate or low virulence http://metadata.un.org/sdg/1 End poverty in all its forms everywhere 8 Pág. African swine fever virus (ASFV) genotype II has been present in wild boar in the European Union since 2014. Control measures have reduced the incidence of the ASF, but highly virulent as well as attenuated ASFV strains continue to circulate. We present the intraherd epidemiological parameters of low and highly virulent ASFV in wild boar from experimental data, and for the first time, evaluate the impact of attenuated strain circulation through unique deterministic compartmental model simulations under various potential scenarios and hypotheses. Using an estimated PCR infectious threshold of TPCR = 36.4, we obtained several transmission parameters, like an Rx (experimental intraherd R0) value of 4.5. We also introduce two novel epidemiological parameters: infectious power and resistance power, which indicate the ability of animals to transmit the infection and the reduction in infectiousness after successive exposures to varying virulence strains, respectively. The presence of ASFV attenuated strains results in 4-17% of animals either remaining in a carrier state or becoming susceptible again when exposed to highly virulent ASFV for more than two years. The timing between exposures to viruses of different virulence also influences the percentage of animals that die or remain susceptible. The findings of this study can be utilized in epidemiological modelling and provide insight into important risk situations that should be considered for surveillance and future potential ASF vaccination strategies in wild boar. This research was funded by the Horizon 2020 Program of the European Union Project “VACDIVA-A Safe DIVA vaccine for African Swine Fever control and eradication” (grant agreement no. 862874 ), the Spanish Ministry of Science and Innovation (Ministerio de Ciencia e Innovación) grant PID2019-106337GB-I00 , and the research group MOMAT (Ref. [910480]) supported by the Complutense University of Madrid. Peer reviewed 2023-09-05T13:05:45Z 2023-09-05T13:05:45Z 2023-09 artículo http://purl.org/coar/resource_type/c_6501 Research in Veterinary Science 0034-5288 http://hdl.handle.net/10261/334568 10.1016/j.rvsc.2023.104964 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100002911 37531717 2-s2.0-85166171675 https://api.elsevier.com/content/abstract/scopus_id/85166171675 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/EC/H2020//862874 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106337GB-I00/ES/MODELIZACION, SIMULACION NUMERICA Y OPTIMIZACION PARA VARIOS PROBLEMAS DE INTERES GENERAL/ Centro de Investigación en Sanidad Animal (CISA) Publisher's version https://doi.org/10.1016/j.rvsc.2023.104964 Sí open application/pdf Elsevier BV |
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ASF transmission African Swine Fever Virus Disease dynamics Modelling Moderate or low virulence http://metadata.un.org/sdg/1 End poverty in all its forms everywhere ASF transmission African Swine Fever Virus Disease dynamics Modelling Moderate or low virulence http://metadata.un.org/sdg/1 End poverty in all its forms everywhere |
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ASF transmission African Swine Fever Virus Disease dynamics Modelling Moderate or low virulence http://metadata.un.org/sdg/1 End poverty in all its forms everywhere ASF transmission African Swine Fever Virus Disease dynamics Modelling Moderate or low virulence http://metadata.un.org/sdg/1 End poverty in all its forms everywhere Martínez Avilés, Marta Bosch, Jaime Ivorra, Benjamin Ramos, Ángel Manuel Satoshi Ito Barasona, Jose A. Sánchez-Vizcaíno, J. M. Epidemiological impacts of attenuated African swine fever virus circulating in wild boar populations |
| description |
8 Pág. |
| author2 |
European Commission |
| author_facet |
European Commission Martínez Avilés, Marta Bosch, Jaime Ivorra, Benjamin Ramos, Ángel Manuel Satoshi Ito Barasona, Jose A. Sánchez-Vizcaíno, J. M. |
| format |
artículo |
| topic_facet |
ASF transmission African Swine Fever Virus Disease dynamics Modelling Moderate or low virulence http://metadata.un.org/sdg/1 End poverty in all its forms everywhere |
| author |
Martínez Avilés, Marta Bosch, Jaime Ivorra, Benjamin Ramos, Ángel Manuel Satoshi Ito Barasona, Jose A. Sánchez-Vizcaíno, J. M. |
| author_sort |
Martínez Avilés, Marta |
| title |
Epidemiological impacts of attenuated African swine fever virus circulating in wild boar populations |
| title_short |
Epidemiological impacts of attenuated African swine fever virus circulating in wild boar populations |
| title_full |
Epidemiological impacts of attenuated African swine fever virus circulating in wild boar populations |
| title_fullStr |
Epidemiological impacts of attenuated African swine fever virus circulating in wild boar populations |
| title_full_unstemmed |
Epidemiological impacts of attenuated African swine fever virus circulating in wild boar populations |
| title_sort |
epidemiological impacts of attenuated african swine fever virus circulating in wild boar populations |
| publisher |
Elsevier BV |
| publishDate |
2023-09 |
| url |
http://hdl.handle.net/10261/334568 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100002911 https://api.elsevier.com/content/abstract/scopus_id/85166171675 |
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1816136465642422272 |