Developmental origins of health and disease in swine implications for animal production and biomedical research
The concept of Developmental Origins of Health and Disease (DOHaD) addresses, from a large set of epidemiological evidences in human beings and translational studies in animal models, both the importance of genetic predisposition and the determinant role of maternal nutrition during pregnancy on adult morphomics and homeostasis. Compelling evidences suggest that both overnutrition and undernutrition may modify the intrauterine environment of the conceptus and may alter the expression of its genome and therefore its phenotype during prenatal and postnatal life. In fact, the DOHaD concept is an extreme shift in the vision of the factors conditioning adult phenotype and supposes a drastic change from a gene-centric perspective, only modified by lifestyle and nutritional strategies during juvenile development and adulthood, to a more holistic approach in which environmental, parental, and prenatal conditions are strongly determining postnatal development and homeostasis. The implications of DOHaD are profound in all the mammalian species and the present review summarizes current knowledge on causes and consequences of DOHaD in pigs, both for meat production and as a well-recognized model for biomedicine research. � 2016 Elsevier Inc.
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Format: | review biblioteca |
Language: | English |
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Elsevier
2016
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Subjects: | Conceptus, Pregnancy, Prenatal programming, Swine, |
Online Access: | http://hdl.handle.net/20.500.12792/1890 http://hdl.handle.net/10261/293728 |
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dig-inia-es-10261-2937282023-02-20T10:31:27Z Developmental origins of health and disease in swine implications for animal production and biomedical research González De Bulnes, Antonio Astiz Blanco, Susana María Óvilo Martín, Cristina López-Bote, C. J. Torres-Rovira, L. Barbero, A. Ayuso, M. García-Contreras, C. Vázquez-Gómez, M. Conceptus Pregnancy Prenatal programming Swine The concept of Developmental Origins of Health and Disease (DOHaD) addresses, from a large set of epidemiological evidences in human beings and translational studies in animal models, both the importance of genetic predisposition and the determinant role of maternal nutrition during pregnancy on adult morphomics and homeostasis. Compelling evidences suggest that both overnutrition and undernutrition may modify the intrauterine environment of the conceptus and may alter the expression of its genome and therefore its phenotype during prenatal and postnatal life. In fact, the DOHaD concept is an extreme shift in the vision of the factors conditioning adult phenotype and supposes a drastic change from a gene-centric perspective, only modified by lifestyle and nutritional strategies during juvenile development and adulthood, to a more holistic approach in which environmental, parental, and prenatal conditions are strongly determining postnatal development and homeostasis. The implications of DOHaD are profound in all the mammalian species and the present review summarizes current knowledge on causes and consequences of DOHaD in pigs, both for meat production and as a well-recognized model for biomedicine research. � 2016 Elsevier Inc. 2023-02-20T10:31:27Z 2023-02-20T10:31:27Z 2016 review Theriogenology 86: 110-119 (2016) 0093-691X http://hdl.handle.net/20.500.12792/1890 http://hdl.handle.net/10261/293728 10.1016/j.theriogenology.2016.03.024 1879-3231 en none Elsevier |
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Conceptus Pregnancy Prenatal programming Swine Conceptus Pregnancy Prenatal programming Swine González De Bulnes, Antonio Astiz Blanco, Susana María Óvilo Martín, Cristina López-Bote, C. J. Torres-Rovira, L. Barbero, A. Ayuso, M. García-Contreras, C. Vázquez-Gómez, M. Developmental origins of health and disease in swine implications for animal production and biomedical research |
description |
The concept of Developmental Origins of Health and Disease (DOHaD) addresses, from a large set of epidemiological evidences in human beings and translational studies in animal models, both the importance of genetic predisposition and the determinant role of maternal nutrition during pregnancy on adult morphomics and homeostasis. Compelling evidences suggest that both overnutrition and undernutrition may modify the intrauterine environment of the conceptus and may alter the expression of its genome and therefore its phenotype during prenatal and postnatal life. In fact, the DOHaD concept is an extreme shift in the vision of the factors conditioning adult phenotype and supposes a drastic change from a gene-centric perspective, only modified by lifestyle and nutritional strategies during juvenile development and adulthood, to a more holistic approach in which environmental, parental, and prenatal conditions are strongly determining postnatal development and homeostasis. The implications of DOHaD are profound in all the mammalian species and the present review summarizes current knowledge on causes and consequences of DOHaD in pigs, both for meat production and as a well-recognized model for biomedicine research. � 2016 Elsevier Inc. |
format |
review |
topic_facet |
Conceptus Pregnancy Prenatal programming Swine |
author |
González De Bulnes, Antonio Astiz Blanco, Susana María Óvilo Martín, Cristina López-Bote, C. J. Torres-Rovira, L. Barbero, A. Ayuso, M. García-Contreras, C. Vázquez-Gómez, M. |
author_facet |
González De Bulnes, Antonio Astiz Blanco, Susana María Óvilo Martín, Cristina López-Bote, C. J. Torres-Rovira, L. Barbero, A. Ayuso, M. García-Contreras, C. Vázquez-Gómez, M. |
author_sort |
González De Bulnes, Antonio |
title |
Developmental origins of health and disease in swine implications for animal production and biomedical research |
title_short |
Developmental origins of health and disease in swine implications for animal production and biomedical research |
title_full |
Developmental origins of health and disease in swine implications for animal production and biomedical research |
title_fullStr |
Developmental origins of health and disease in swine implications for animal production and biomedical research |
title_full_unstemmed |
Developmental origins of health and disease in swine implications for animal production and biomedical research |
title_sort |
developmental origins of health and disease in swine implications for animal production and biomedical research |
publisher |
Elsevier |
publishDate |
2016 |
url |
http://hdl.handle.net/20.500.12792/1890 http://hdl.handle.net/10261/293728 |
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