Progestogen treatments for cycle management in a sheep model of assisted conception affect the growth patterns, the expression of luteinizing hormone receptors, and the progesterone secretion of induced corpora lutea

Objective To determine, in a sheep model, the effect of a short-term progestative treatment on growth dynamics and functionality of induced corpora lutea. Design Observational, model study. Setting Public university. Patient(s) Sixty adult female sheep. Intervention(s) Synchronization and induction of ovulation with progestogens and prostaglandin analogues; ovarian ultrasonography, blood sampling, and ovariectomy. Main Outcome Measure(s) Determination of pituitary function and morphologic characteristics, expression of luteinizing hormone (LH) receptors, and progesterone secretion of corpora lutea. Result(s) The use of progestative pretreatments for assisted conception affect the growth patterns, the expression of LH receptors, and the progesterone secretion of induced corpora lutea. Conclusion(s): The current study indicates, in a sheep model, the existence of deleterious effects from progestogens on functionality of induced corpora lutea. © 2010 American Society for Reproductive Medicine.

Bibliographic Details

Main Authors:	Letelier, C., García-Fernández, R. A., Contreras-Solis, I., Sanchez, M. A., Garcia-Palencia, P., Sanchez, B., González De Bulnes, Antonio, Flores, J. M.
Format:	journal article biblioteca
Language:	English
Published:	Elsevier 2010
Subjects:	Progestogens, Pituitary function, Luteal function, LH receptors, Sheep,
Online Access:	http://hdl.handle.net/20.500.12792/2371 http://hdl.handle.net/10261/293704
Tags:	Add Tag No Tags, Be the first to tag this record!