Slow-stirring method for determining the n-octanol/water partition coefficient (Pow) for highly hydrophobic chemicals Performance evaluation in a ring test
The n-octanol/water partition coefficient (Pow) is one of the most important parameters employed for estimating a chemical's environmental fate and toxicity. The currently adopted test guidelines for its determination do not allow for reliable determination of log Pow greater than 5. The slow-stirring experiment, in contrast, has been demonstrated to provide reliable log Pow data up to log Pow of 8.3. To validate this method and to obtain its approval as an official Organization for Economic Cooperation and Development (Paris, France) test guideline, a ring test was performed to evaluate the accuracy and precision of the slow-stirring experiment for determination of log Pow, particularly for highly hydrophobic compounds. Up to 15 volunteer laboratories tested 1,2,3,4-tetrachlorobenzene, hexachlorobenzene, 2,2′,3,3′,5,5′,6,6′-octachlorobiphenyl, and decachlorobiphenyl (4.5 < log Pow < 8.2). The ring-test results for the respective chemicals were 4.62, 5.50, 7.39, and 8.18. The results deviated by less than 0.1 log Pow units from the reference log Pow. In addition, the relative standard deviations of log Pow were less than 2%. Using the protocol of the ring test, log Pow of p,p'-DDT was determined to be 6.24 ± 0.05 (mean ± standard deviation). In combination, these results indicate that the slow-stirring method is precise and accurate and, thus, allows for reliable determination of log Pow of highly hydrophobic chemicals.
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Format: | artículo biblioteca |
Language: | English |
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Wiley
2003
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Subjects: | Slow-stirring method, Ring test, Hydrophobic chemicals, n-Octanol/water partition coefficient, |
Online Access: | http://hdl.handle.net/20.500.12792/4497 http://hdl.handle.net/10261/289990 |
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dig-inia-es-10261-2899902023-02-17T08:26:15Z Slow-stirring method for determining the n-octanol/water partition coefficient (Pow) for highly hydrophobic chemicals Performance evaluation in a ring test Tolls, J. Bodo, K. De Felip, E. Dujardin, R. Kim, Y. H. Moeller-Jensen, L. Mullee, D. Nakajima, A. Paschke, A. Pawliczek, J. B. Schneider, J. Tadeo Lluch, José Luis Tognucci, A. C. Webb, J. Corneel Zwijzen, A. Slow-stirring method Ring test Hydrophobic chemicals n-Octanol/water partition coefficient The n-octanol/water partition coefficient (Pow) is one of the most important parameters employed for estimating a chemical's environmental fate and toxicity. The currently adopted test guidelines for its determination do not allow for reliable determination of log Pow greater than 5. The slow-stirring experiment, in contrast, has been demonstrated to provide reliable log Pow data up to log Pow of 8.3. To validate this method and to obtain its approval as an official Organization for Economic Cooperation and Development (Paris, France) test guideline, a ring test was performed to evaluate the accuracy and precision of the slow-stirring experiment for determination of log Pow, particularly for highly hydrophobic compounds. Up to 15 volunteer laboratories tested 1,2,3,4-tetrachlorobenzene, hexachlorobenzene, 2,2′,3,3′,5,5′,6,6′-octachlorobiphenyl, and decachlorobiphenyl (4.5 < log Pow < 8.2). The ring-test results for the respective chemicals were 4.62, 5.50, 7.39, and 8.18. The results deviated by less than 0.1 log Pow units from the reference log Pow. In addition, the relative standard deviations of log Pow were less than 2%. Using the protocol of the ring test, log Pow of p,p'-DDT was determined to be 6.24 ± 0.05 (mean ± standard deviation). In combination, these results indicate that the slow-stirring method is precise and accurate and, thus, allows for reliable determination of log Pow of highly hydrophobic chemicals. 2023-02-17T08:26:15Z 2023-02-17T08:26:15Z 2003 artículo Environmental Toxicology and Chemistry 22(5): 1051-1057 (2003) 0730-7268 http://hdl.handle.net/20.500.12792/4497 http://hdl.handle.net/10261/289990 10.1897/1551-5028(2003)022<1051SMFDTW>2.0.CO;2 1552-8618 en none Wiley |
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Slow-stirring method Ring test Hydrophobic chemicals n-Octanol/water partition coefficient Slow-stirring method Ring test Hydrophobic chemicals n-Octanol/water partition coefficient |
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Slow-stirring method Ring test Hydrophobic chemicals n-Octanol/water partition coefficient Slow-stirring method Ring test Hydrophobic chemicals n-Octanol/water partition coefficient Tolls, J. Bodo, K. De Felip, E. Dujardin, R. Kim, Y. H. Moeller-Jensen, L. Mullee, D. Nakajima, A. Paschke, A. Pawliczek, J. B. Schneider, J. Tadeo Lluch, José Luis Tognucci, A. C. Webb, J. Corneel Zwijzen, A. Slow-stirring method for determining the n-octanol/water partition coefficient (Pow) for highly hydrophobic chemicals Performance evaluation in a ring test |
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The n-octanol/water partition coefficient (Pow) is one of the most important parameters employed for estimating a chemical's environmental fate and toxicity. The currently adopted test guidelines for its determination do not allow for reliable determination of log Pow greater than 5. The slow-stirring experiment, in contrast, has been demonstrated to provide reliable log Pow data up to log Pow of 8.3. To validate this method and to obtain its approval as an official Organization for Economic Cooperation and Development (Paris, France) test guideline, a ring test was performed to evaluate the accuracy and precision of the slow-stirring experiment for determination of log Pow, particularly for highly hydrophobic compounds. Up to 15 volunteer laboratories tested 1,2,3,4-tetrachlorobenzene, hexachlorobenzene, 2,2′,3,3′,5,5′,6,6′-octachlorobiphenyl, and decachlorobiphenyl (4.5 < log Pow < 8.2). The ring-test results for the respective chemicals were 4.62, 5.50, 7.39, and 8.18. The results deviated by less than 0.1 log Pow units from the reference log Pow. In addition, the relative standard deviations of log Pow were less than 2%. Using the protocol of the ring test, log Pow of p,p'-DDT was determined to be 6.24 ± 0.05 (mean ± standard deviation). In combination, these results indicate that the slow-stirring method is precise and accurate and, thus, allows for reliable determination of log Pow of highly hydrophobic chemicals. |
format |
artículo |
topic_facet |
Slow-stirring method Ring test Hydrophobic chemicals n-Octanol/water partition coefficient |
author |
Tolls, J. Bodo, K. De Felip, E. Dujardin, R. Kim, Y. H. Moeller-Jensen, L. Mullee, D. Nakajima, A. Paschke, A. Pawliczek, J. B. Schneider, J. Tadeo Lluch, José Luis Tognucci, A. C. Webb, J. Corneel Zwijzen, A. |
author_facet |
Tolls, J. Bodo, K. De Felip, E. Dujardin, R. Kim, Y. H. Moeller-Jensen, L. Mullee, D. Nakajima, A. Paschke, A. Pawliczek, J. B. Schneider, J. Tadeo Lluch, José Luis Tognucci, A. C. Webb, J. Corneel Zwijzen, A. |
author_sort |
Tolls, J. |
title |
Slow-stirring method for determining the n-octanol/water partition coefficient (Pow) for highly hydrophobic chemicals Performance evaluation in a ring test |
title_short |
Slow-stirring method for determining the n-octanol/water partition coefficient (Pow) for highly hydrophobic chemicals Performance evaluation in a ring test |
title_full |
Slow-stirring method for determining the n-octanol/water partition coefficient (Pow) for highly hydrophobic chemicals Performance evaluation in a ring test |
title_fullStr |
Slow-stirring method for determining the n-octanol/water partition coefficient (Pow) for highly hydrophobic chemicals Performance evaluation in a ring test |
title_full_unstemmed |
Slow-stirring method for determining the n-octanol/water partition coefficient (Pow) for highly hydrophobic chemicals Performance evaluation in a ring test |
title_sort |
slow-stirring method for determining the n-octanol/water partition coefficient (pow) for highly hydrophobic chemicals performance evaluation in a ring test |
publisher |
Wiley |
publishDate |
2003 |
url |
http://hdl.handle.net/20.500.12792/4497 http://hdl.handle.net/10261/289990 |
work_keys_str_mv |
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