Recurrent outbreaks of myelodysplasia in newborn calves
7 páginas, 5 figuras, 1 tabla.
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| Format: | artículo biblioteca |
| Language: | English |
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Elsevier
2012
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| Subjects: | Cattle, Congenital defect, Myelodysplasia, Neuroteratogen, Spinal cord, |
| Online Access: | http://hdl.handle.net/10261/80190 |
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dig-igm-es-10261-801902021-04-13T14:53:32Z Recurrent outbreaks of myelodysplasia in newborn calves Polledo, Laura García Marín, Juan Francisco Martínez Fernández, B. González, J. Alonso, J. Salceda, W. García Iglesias, M. J. Cattle Congenital defect Myelodysplasia Neuroteratogen Spinal cord 7 páginas, 5 figuras, 1 tabla. The present study records recurrent outbreaks of myelodysplasia of unknown origin occurring in a specific geographical location in the north of Spain, and involving up to 30% of the calves born in affected herds. The affected calves were of different breeds and displayed non-progressive signs of spinal cord dysfunction. The disease has occurred annually in February-March over a period of at least 15 years. Only calves born to cattle grazed on mountainside pastures and under high grazing pressure were affected. Seven calves were subjected to necropsy examination. Myelodysplasia was not associated with vertebral defects or arthrogryposis and involved the entire length of the spinal cord. Microscopically, there was abnormal distribution of the grey matter, aberrations of the central canal and failure of formation of the ventral median fissure. Infectious, nutritional and physical disorders were ruled out as possible aetiologies. A critical period of embryonic susceptibility to the causal agent was identified. This was during the time of secondary neurulation when cows in the early stages of gestation were grazed on mountainside pastures. Consequently, the presence of neuroteratogenic plants in these pastures is proposed as a likely cause. Two plants, Carex brevicollis and Erythroniuni dens-canis, which contain alkaloids, were identified on the mountainsides where affected cattle were grazed and not in other pastures, and are proposed as the possible aetiology of the disease. L. Polledo holds a grant from the Ministry of Education (AP2007-02007). Peer reviewed 2013-07-25T08:58:26Z 2013-07-25T08:58:26Z 2012 artículo http://purl.org/coar/resource_type/c_6501 Journal of Comparative Pathology 147: 479-485 (2012) 0021-9975 http://hdl.handle.net/10261/80190 10.1016/j.jcpa.2012.03.002 en http://dx.doi.org/10.1016/j.jcpa.2012.03.002 open Elsevier |
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Biblioteca del IGM España |
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English |
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Cattle Congenital defect Myelodysplasia Neuroteratogen Spinal cord Cattle Congenital defect Myelodysplasia Neuroteratogen Spinal cord |
| spellingShingle |
Cattle Congenital defect Myelodysplasia Neuroteratogen Spinal cord Cattle Congenital defect Myelodysplasia Neuroteratogen Spinal cord Polledo, Laura García Marín, Juan Francisco Martínez Fernández, B. González, J. Alonso, J. Salceda, W. García Iglesias, M. J. Recurrent outbreaks of myelodysplasia in newborn calves |
| description |
7 páginas, 5 figuras, 1 tabla. |
| format |
artículo |
| topic_facet |
Cattle Congenital defect Myelodysplasia Neuroteratogen Spinal cord |
| author |
Polledo, Laura García Marín, Juan Francisco Martínez Fernández, B. González, J. Alonso, J. Salceda, W. García Iglesias, M. J. |
| author_facet |
Polledo, Laura García Marín, Juan Francisco Martínez Fernández, B. González, J. Alonso, J. Salceda, W. García Iglesias, M. J. |
| author_sort |
Polledo, Laura |
| title |
Recurrent outbreaks of myelodysplasia in newborn calves |
| title_short |
Recurrent outbreaks of myelodysplasia in newborn calves |
| title_full |
Recurrent outbreaks of myelodysplasia in newborn calves |
| title_fullStr |
Recurrent outbreaks of myelodysplasia in newborn calves |
| title_full_unstemmed |
Recurrent outbreaks of myelodysplasia in newborn calves |
| title_sort |
recurrent outbreaks of myelodysplasia in newborn calves |
| publisher |
Elsevier |
| publishDate |
2012 |
| url |
http://hdl.handle.net/10261/80190 |
| work_keys_str_mv |
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| _version_ |
1777663934459805696 |