Adaptation of Staphylococcus aureus to ruminant and equine hosts involves SaPI-carried variants of von Willebrand factor-binding protein
Lasa, Íñigo [et. al]. 12 p., 6 figures, 3 tables and bibliography
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2010-09
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dig-igm-es-10261-488532016-02-17T07:56:26Z Adaptation of Staphylococcus aureus to ruminant and equine hosts involves SaPI-carried variants of von Willebrand factor-binding protein Lasa, Íñigo Penadés, José R. Lasa, Íñigo [et. al]. 12 p., 6 figures, 3 tables and bibliography Staphylococci adapt specifically to various animal hosts by genetically determined mechanisms that are not well understood. One such adaptation involves the ability to coagulate host plasma, by which strains isolated from ruminants or horses can be differentiated from closely related human strains. Here, we report first that this differential coagulation activity is due to animal-specific alleles of the von Willebrand factor-binding protein (vWbp) gene, vwb, and second that these vwb alleles are carried by highly mobile pathogenicity islands, SaPIs. Although all Staphylococcus aureus possess chromosomal vwb as well as coagulase (coa) genes, neither confers species-specific coagulation activity; however, the SaPI-coded vWbps possess a unique N-terminal region specific for the activation of ruminant and equine prothrombin. vWbp-encoding SaPIs are widely distributed among S. aureus strains infecting ruminant or equine hosts, and we have identified and characterized four of these, SaPIbov4, SaPIbov5, SaPIeq1 and SaPIov2, which encode vWbp Sbo4, vWbpSbo5, vWbpSeq1 and vWbp Sov2 respectively. Moreover, the SaPI-carried vwb genes are regulated differently from the chromosomal vwb genes of the same strains. We suggest that the SaPI-encoded vWbps may represent an important host adaptation mechanism for S. aureus pathogenicity, and therefore that acquisition of vWbp-encoding SaPIs may be determinative for animal specificity. This work was supported by Grants Consolider-Ingenio CSD2009-00006, BIO2005-08399-C02-02, BIO2008-05284-C02-02 and BIO2008-00642-E/C from the Ministerio de Ciencia e Innovación (MICINN), and grants from the Cardenal Herrera-CEU University (PRCEU-UCH25/08 and Copernicus-Banco Santander programme), from the Conselleria de Agricultura, Pesca i Alimentació (CAPiA) and from the Generalitat Valenciana to J.R.P., by Grant AGL2008-00273/ GAN from MICINN to J.M.C., and by Grant BB/D521222/1 from the Biotechnology and Biological Sciences Research Council to J.R.F. Peer reviewed 2012-04-24T12:31:09Z 2012-04-24T12:31:09Z 2010-09 artículo http://purl.org/coar/resource_type/c_6501 Molecular Microbiology 77(6): 1583-1594 (2010) 0950-382X http://hdl.handle.net/10261/48853 10.1111/j.1365-2958.2010.07312.x 1365-2958 en http://dx.doi.org/10.1111/j.1365-2958.2010.07312.x none Blackwell Publishing |
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English |
| description |
Lasa, Íñigo [et. al]. 12 p., 6 figures, 3 tables and bibliography |
| format |
artículo |
| author |
Lasa, Íñigo Penadés, José R. |
| spellingShingle |
Lasa, Íñigo Penadés, José R. Adaptation of Staphylococcus aureus to ruminant and equine hosts involves SaPI-carried variants of von Willebrand factor-binding protein |
| author_facet |
Lasa, Íñigo Penadés, José R. |
| author_sort |
Lasa, Íñigo |
| title |
Adaptation of Staphylococcus aureus to ruminant and equine hosts involves SaPI-carried variants of von Willebrand factor-binding protein |
| title_short |
Adaptation of Staphylococcus aureus to ruminant and equine hosts involves SaPI-carried variants of von Willebrand factor-binding protein |
| title_full |
Adaptation of Staphylococcus aureus to ruminant and equine hosts involves SaPI-carried variants of von Willebrand factor-binding protein |
| title_fullStr |
Adaptation of Staphylococcus aureus to ruminant and equine hosts involves SaPI-carried variants of von Willebrand factor-binding protein |
| title_full_unstemmed |
Adaptation of Staphylococcus aureus to ruminant and equine hosts involves SaPI-carried variants of von Willebrand factor-binding protein |
| title_sort |
adaptation of staphylococcus aureus to ruminant and equine hosts involves sapi-carried variants of von willebrand factor-binding protein |
| publisher |
Blackwell Publishing |
| publishDate |
2010-09 |
| url |
http://hdl.handle.net/10261/48853 |
| work_keys_str_mv |
AT lasainigo adaptationofstaphylococcusaureustoruminantandequinehostsinvolvessapicarriedvariantsofvonwillebrandfactorbindingprotein AT penadesjoser adaptationofstaphylococcusaureustoruminantandequinehostsinvolvessapicarriedvariantsofvonwillebrandfactorbindingprotein |
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1777663904095141888 |